Partial inversion of the secondary constriction of chromosome 9: it exists.
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Chromosome Banding↗
Biomedical subjects
B Tedeschi
Publications and source records attributed to B Tedeschi.
Are axonally transported proteins released from sciatic nerves?
A recent report by Hines and Garwood claimed a significant release of axonally transported proteins from frog sciatic nerve into a surrounding solution. In the present study no significant release of axonally transported protein from frog sciatic nerves was detected with more stringent control for non-axonal sources of released protein.
Animals↗
Developmental changes in brain template active region chromatin.
The percentage of brain or liver chromatin in the template-active region was examined in rats of varying ages. Prenatally, there was an increase in the percentage of brain template-active region chromatin which declined near birth. After birth, the percentage of brain template-active region chromatin again increased to 3-6 days of age and then declined to adult levels at about 15 days of age. Liver exhibited a similar gestational change in the percentage of template-active region chromatin, but there was no recovery from the birth decline during postnatal development. These findings are discussed in terms of their contribution to the understanding of age-dependent changes in brain transcription.
Aging↗
A balanced translocation t(4;9) (q35;q12) with a breakpoint within the heterochromatic region of chromosome 9 in a woman with recurrent abortion.
A case of recurrent abortion was found to be associated with the presence in the mother of a balanced translocation between chromosomes 4 and 9. The karyotypes of the proposita was: 46,XX,t(4;9)(q35;q12). The effects of this translocation are discussed in the light of other cases reported in the literature.
Abortion, Habitual↗
Effects of a novel experience on rat brain chromatin.
In this study adult Fischer, inbred rats experienced (1) training to avoid footshock (2) unavoidable footshock or (3) no training or footshock. Each animal was sacrificed at one of several time points (1-60 hours) following experience. Brain chromatin was extracted and used as template for RNA synthesis in vitro. Both groups which received the novel experience demonstrated greater template activity than the unshocked, untrained groups. This effect was brief. The two groups which received the experience did not differ from each other. These results suggest that a brief, novel experience can temporarily alter the transcriptional activity of brain chromatin.
Animals↗
Environmental enrichment and brain chromatin.
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Animals↗
Enhanced chromosomal fragility in neuroblastoma: correlation with poor prognosis.
In a previous study we demonstrated spontaneous fragility and hypersensitivity to fragile site induction by aphidicolin in lymphocytes from some neuroblastoma patients and their parents. Here we report data based on a total of 40 patients and 37 families. Possible correlations between higher sensitivity to aphidicolin and a variety of personal and clinical characteristics were verified. Patients with a poor prognosis generally proved to be more susceptible to fragile site induction.
Adult↗