[Potential marker rhythms in multiple myeloma (notes on clinical chronobiology)].
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Biomedical subjects
Publications and source records attributed to B Tarquini.
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After days of standardized conditions of life and standardized diets, serum gastrin levels were measured in 6 patients with liver cirrhosis on 3 consecutive days and in 14 normal controls on 1 day. Blood samples were drawn every 4 h. In patients as well as in controls, a significant serum gastrin circadian rhythm was noted. The daily mean serum gastrin levels of patients were not significantly different from those of controls. These results suggest a secondary role of the liver in gastrin metabolism.
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The pattern of immunoreactive prolactin secretion over 24 hr in a group of patients suffering from cirrhosis of the liver has been studied and compared to that of healthy controls. The results were analyzed by use of chronograms and by mean cosinor. Although the daily mean average secretion of serum prolactin by the cirrhotics is not different from that of the control subjects utilizing the standard t-test, cosinor analysis of the data fails to demonstrate a circadian rhythm for prolactin secretion in the cirrhotics. These results are discussed in view of the apparent clinical hyperestrogenization and known changes in electrolyte balance which are commonly found in persons with advanced liver disease.
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