Biomedical subjects

B Tandler

Publications and source records attributed to B Tandler.

147 records · Page 9Linked to original sources

PubMedDate not supplied

Three-dimensional structure of oncocyte mitochondria in human salivary glands: a scanning electron microscope study.

Oncocytes occurring in otherwise normal human salivary glands were examined by scanning electron microscopy after being subjected to a maceration technique that removes all soluble cytoplasmic components and leaves only membranes in place. The three-dimensional images resulting from this procedure confirm that the majority of oncocyte mitochondria have shelf-like cristae that are attached to the inner boundary membrane, often by means of tubular structures. In some mitochondria, the cristae are digitiform and, when transected, give rise to putative vesicles. The oncocytic mitochondria in human salivary glands, by and large, lack the structural irregularity that has been reported for these organelles occurring in oncocytes in other organs.

Aged↗

PubMedDate not supplied

Scanning electron microscopy of the interior of cells in Hürthle cell tumors.

Four cases of Hürthle cell tumor were examined by scanning electron microscopy after being macerated to remove all soluble components. By all morphological criteria, Hürthle cells are oncocytes with their usual augmented complement of mitochondria. The Hürthle cell mitochondria either are ovate with central stacks of cristae or elliptical or rod-like with cristae that often are finger-like. As in salivary gland oncocytes, the shelf-like cristae are anchored to the inner boundary membrane by tubular necks. In some Hürthle cells, all of the mitochondria exhibit reticulate cristae. A few mitochondria harbor a globular inclusion in their inner compartment. The Golgi apparatuses are relatively simple, consisting of imbricated saccules that are edged by small, bud-like structures. The rare lumina in the midst of clusters of Hürthle cells are lined by numerous microvilli. Thus, scanning electron microscopy of macerated Hürthle cell tumors has revealed a number of features, especially of their mitochondria, that have escaped detection by transmission electron microscopy.

Adenoma, Oxyphilic↗

PubMedDate not supplied

Altered serous granules in acinar cells of a human parotid gland.

A peculiar alteration of secretory granule morphology was observed in serous cells of the parotid gland from a patient undergoing radical neck surgery for oral cancer. The granules were half filled with a dense material that in early stages of formation appeared to consist of filaments or fine tubules. Growth of these apparently rigid fibrillar structures caused the formation of long pseudopodia on the granule surface. Granule alterations were not due to preoperative treatment because the patient had had none. It is postulated that the granule alterations were due to a perturbation in granule composition, possibly because of a genetic mutation that led to changes in one or more of the proline-rich proteins that normally reside in parotid serous granules.

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