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Biomedical subjects

B Tabakoff

Publications and source records attributed to B Tabakoff.

At least 217 records · Page 12Linked to original sources
PubMed1976

Studies on the effects of pyrogallol and the structurally related dopa decarboxylase inhibitor RO4-4602 on acetaldehyde metabolism.

Microanalytic procedures for the determination of AcH in whole blood from EtOH-intoxicated animals given PG or related drugs should utilize a hemolysis step in 0.5 N PCA in order to inhibit PG-dependent AcH production in vitro. Thiourea may also be included as an added protective measure. RO4-4602, a clinically important drug that contains a PG ring structure, is a moderate in vitro inhibitor of AldDH activity, comparable in potency to PG, chloral hydrate, or diethyldithiocarbamate.

Acetaldehyde↗
PubMed1976

Ontogenesis of serotonergic systems in rat brain.

It was shown that the concentration of brain 5-HT rises slowly, reaching mature values by 80 days of age, while the catabolic product of 5-HT, i.e., 5-HIAA, drops from a high perinatal value to lower values by adulthood. This is indicated of poorly developed storage mechanisms at this early period in life. It was also shown that MAO develops at a rapid rate, acquiring mature values by 20 days. The activity of MAO towards substrates develops at different rates, although the general pattern of development is the same.

Age Factors↗
PubMed1976

Body temperature in mice: a quantitative measure of alcohol tolerance and physical dependence.

Mice undergoing withdrawal after chronic ethanol consumption were found to be hypothermic if kept at room temperature. The extent of the hypothermia correlated well with the behavioral withdrawal symptoms and could be used as a quantitative measure of the severity and time course of the withdrawal syndrome. Placing mice in a cold environment (4 degrees C) exacerbated the hypothermia whereas placing animals at 34 degrees C reversed the hypothermia and produced hyperthermia. It was concluded that the temperature set point mechanism and the ability to regulate around this set point was disturbed in animals physically dependent on alcohol. During consumption of the ethanol-containing diets, mice exhibited tolerance to the hypothermic effects of an acutely administered dose od ethanol. Tolerance to the hypothermic effects of ethanol mirrored the development of behavioral tolerance as measured by performance on a tilting plane. Temperature and behavioral tolerance were both shown to extend well beyond the period of the withdrawal syndrome. Ethanol-treated mice were found to be cross-tolerant to the hypothermic effects of barbiturates but not to the hypothermia produced by the monoamine oxidase inhibitor, pargyline.

Animals↗
PubMed1975

Ontogeny of multiple forms of monoamine oxidase in mouse brain.

MAO activities in mouse brain responsible for deamination of serotonin (5-HT) and p-dimethylaminobenzylamine (DAB) were found to follow different postnatal developmental patterns. MAO activity which deaminated 5-HT reached adult levels 15 days after birth. At this age the capacity of brain to deaminate DAB was only 50% of adult levels and did not develop fully until after the 45th postnatal day. Inhibitor studies with Deprenil and clorgyline indicated that the deamination of the two substrates was due to different forms of MAO and that these forms were similar to type A and type B MAO described previously in rat brain.

Age Factors↗