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Biomedical subjects

B T Winslow

Publications and source records attributed to B T Winslow.

2 recordsLinked to original sources

Intussusception.

Intussusception is the invagination of one bowel segment into another. It is an emergent condition that most commonly affects infants between five and nine months of age, but it can also occur in other age groups. The etiology is usually idiopathic in infants five to nine months of age; neonates, older children and adults more commonly have lead points such as a Meckel's diverticulum or a neoplasm. Early diagnosis is essential to avoid treatment delays, which can increase morbidity and mortality. It has been reported that patients with intussusception present with abdominal pain, vomiting and bloody stools, but this classic triad is often absent. More commonly, lethargy and irritability are the presenting signs. A rectal examination, with testing for occult blood, is an important part of the evaluation and is frequently positive. Barium enema is the gold standard for diagnosis and also has therapeutic potential for reducing the intussusception. Ultrasound is an accurate, low-risk screening tool when performed and interpreted by an experienced ultrasonographer. Surgical reduction is performed if nonoperative reduction is contraindicated or unsuccessful, or if a lead point is suspected.

Humans

Corticosteroids inhibit the differentiation of U937 cells induced by the combination of lymphocyte-conditioned media and calcitriol.

Corticosteroids improve humoral hypercalcemia of malignancy in some patients presumably by decreasing osteoclast activity or number. Using the monoblastic U937 cell line as a model of osteoclast formation, it is shown that hydrocortisone (10(-6)M) and dexamethasone (10(-6)M) completely inhibited lymphokine-induced formation of mature, adherent cells. These changes were concentration dependent and specific for corticosteroids since neither progesterone nor 17 beta-estradiol produced similar effects. When used alone none of these hormones had toxic effects on U936 cells nor did they directly cause differentiation. These data are consistent with the possibility that in some types of humoral hypercalcemia of malignancy corticosteroids may work by inhibiting osteoclast formation from their precursors.

Adrenal Cortex Hormones