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Biomedical subjects

B T Marsh

Publications and source records attributed to B T Marsh.

22 records · Page 2Linked to original sources
PubMed1975

The planning of a clinical trials workshop.

The groundwork involved in the planning and running of a Clinical Trials Workshop using a computerized simulation exercise called 'Instant Experience' is described in detail. 2. Groups of six or seven students, each with an experienced tutor, are set the problem of designing a clinical trial protocol for a given drug. By using a computer programme, results can be generated for these designs according to pre-set rules laid down by the organizers. 3. The game itself acts as a vehicle for emphasizing the practical and theoretical problems associated with clinical trials. Further valuable information can be imparted during the group discussion periods when the trial design is being developed and during analysis of the results. 4. Limitations of this type of workshop include the need for students to have a working knowledge of clinical medicine and pharmacology, the competence of the tutors and organizers and the technical problems associated with computers and a comparatively rigid computer programme. 5. The value of this type of workshop lies in its ability to allow students to apply themselves to practical problems in clinical trials and to make mistakes with no harm to the patient.

Computer-Assisted Instruction↗
PubMedDate not supplied

A post-marketing acceptability study in 11,685 patients of the efficacy of timolol/bendrofluazide in the management of hypertension in general practice.

A post-marketing acceptability study was performed in 11,685 patients to assess the efficacy and acceptability of 10 mg timolol/2.5 mg bendrofluazide in patients with mild to moderate hypertension in general practice. The initial dose was 1 tablet/day. This was adjusted at weekly intervals up to a maximum of 4 tablets/day or until blood pressures of less than or equal to 95 mmHg diastolic or, in patients of greater than or equal to 60 years, less than or equal to 100 mmHg plus the patient's age (in years) systolic, were achieved. Stabilized patients were followed-up after 12, 24 and 48 weeks. Of the patients enrolled, 69% (8039) were successfully treated for at least 8 weeks, 26% (3033) were withdrawn and 5% (613) defaulted. One tablet/day was required by 61% of patients and 29% required 2 tablets/day to achieve stabilization. The mean reductions in systolic and diastolic blood pressures and pulse rate were 31 and 19 mmHg, and 11 beats/min, respectively. Over 60% of the patients enrolled were still taking timolol/bendrofluazide after 12 months' continuous therapy. The most frequently reported reason for withdrawal was an 'adverse event' which occurred in 15.4% (1805) of patients. Only 1.9% (217) failed to achieve target blood pressure on 4 tablets/day. This large study has shown timolol/bendrofluazide to be a highly effective and acceptable once daily therapy for mild to moderate hypertension in general practice.

Adult↗
PubMedDate not supplied

Housing and health. The role of the environmental health practitioner.

From a health standpoint, the residential environment is both the dwelling and its associated areas. The dwelling and related area are interrelated both in terms of sanitation problems affecting physical health and other problems affecting mental health. The residential environment certainly represents a complicated public health problem. The issue of inadequate shelter has been addressed throughout history, but the relationship of shelter and health brings it to our attention now. It is estimated that one out of every four persons in our nation lives with some kind of shelter deficiency. The Federal Housing Act of 1949 was instrumental in creating an awareness that the quality of shelter and the surrounding environment has a great influence upon the physical and mental health and well-being of each individual. When the Housing Act of 1949 was passed, the American Public Health Association Committee on the Hygiene of Housing acknowledged the role public health agencies would have in eliminating and preventing health hazards associated with substandard dwellings. It also recognized the need for a formal code to establish minimum standards for the condition and maintenance of dwellings.

Building Codes↗