The pathogenesis of congenital cardiovascular anomalies.
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Biomedical subjects
Publications and source records attributed to B T Jackson.
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Tracheal obstruction to promote lung growth may be a less aggressive alternative to open fetal surgery in the antenatal treatment of congenital diaphragmatic hernia. Herein, we explore the feasibility of placing an occluding device through fetal tracheoscopy. A self-expanding umbrella allowed adequate sealing of the tracheal lumen even as the tracheal diameter more than doubled between 110 and 138 days of gestation (term = 145 days) in a sheep model. Distal intratracheal pressures after umbrella placement, and lung weight at delivery, were comparable to those after formal tracheal ligation.
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