Postpartum aggression in C57BL/6J and DBA/2J mice: experiential and environmental influences.
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Biomedical subjects
Publications and source records attributed to B Svare.
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Female Rockland-Swiss albino mice were treated for aggression during 6 successive pregnancies and lactation periods or until they ceased to re-mate. Fighting behavior was limited only to the lactation phase of each reproductive cycle. Although most animals exhibited fighting during every lactation period they completed, some exhibited fighting in some lactation periods but not in others. The intensity of aggression, as measured by the time spent fighting, was highest during the beginning of each lactation period and declined by the end of each period. Moreover, the intensity of aggression increased across the first 3 lactation periods and then declined on later lactation periods to a point below initial levels. Finally, the fighting behavior exhibited by multiparous animals was not due simply to previous fighting experience in that some multiparous mice exhibited postpartum aggression on the 6th lactation period in the absence of fighting experience during earlier lactation periods.
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Testosterone propionate (TP) administered from Day 21 through Day 50 of life enhanced the aggressiveness of castrated and neonatally TP-treated juvenile male and female mice and, to a lesser extent, enhanced the aggressiveness of nonneonatally androgenized females. In addition, the enhanced aggressive behavior of juvenile male and female mice was directed principally toward juvenile male but not female opponents and was inhibited by the application of urine from juvenile females to the fur of juvenile male opponents. These experiments indicate that androgen and olfactory stimuli modulate the aggressive behavior of juvenile mice in a manner similar to that of adult animals.