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Biomedical subjects

B Summers

Publications and source records attributed to B Summers.

17 recordsLinked to original sources
PubMed1992

The role of the advanced practice oncology nurse in pain relief.

Oncology nurses have consistently identified relief of pain as a major priority for their specialty. Although many articles provide nurses with advice on ways to improve pain management for people with cancer, few address the practicality and likelihood of these strategies being implemented by an individual nurse. Oncology nurses in advanced practice roles are often in ideal situations to effect some of the positive, broad changes that are needed to improve pain relief. This paper describes the unique contribution that nurses in advanced practice roles can make to pain management and offers a prescription for leadership in practice that can enhance effective pain management for people with cancer.

Education, Nursing, Graduate↗
PubMed1991

Platelet activating factors (AGEPC) from epidermal secretions of the Arabian Gulf catfish, Arius bilineatus, which stimulate wound healing.

High levels of platelet activating factor (PAF) activity were demonstrated by platelet aggregation and serotonin release assays to be present in fright induced epidermal secretions of the Arabian Gulf catfish, Arius bilineatus (Valenciennes, 1840). The PAF activity was purified by thin-layer chromatography. Mass spectral analysis combined with chemical and enzymatic modification of the purified PAF and inhibitor studies indicated that PAF activity was due to the presence of 1-O-alkyl-2-acetyl-sn-glycero-3-phosphorylcholine (AGEPC) molecules. The total AGEPC concentration in the epidermal secretions based on PAF assays was 8 x 10(8) M, well above the threshold level for platelet activation which is near 5 x 10(-11) M. Thus, stimulated epidermal secretory cells of Arius bilineatus supply platelet activating molecules at physiologically high concentrations to sites of injury.

Animals↗
PubMed1991

Evaluation of a communications skills workshop for hospital pharmacists.

The ability to communicate is an essential requirement for effective practice. Until recently, however, pharmacy students received no training in this area. The resultant inadequacy was carried forward into practice. Only now has the omission been recognized and attempts made to improve the situation among practising pharmacists. We designed an 8-h workshop on communication skills. It covered the basic principles of communication (Workbook A--preparatory work before the workshop) and their application (Workbook B + case studies, exercises and role-playing--during the workshop). The workshop was presented to a group of hospital pharmacists in the Western Cape. At the end of the workshop participants completed a questionnaire on its usefulness, applicability and presentation on a five-point scale. Responses were counted, averaged and analysed by sex and age. Although the ratings were uniformly high (average 4.3 out of a possible 5.0) there were differences between men and women and between older and younger pharmacists. The possible reasons for and implications of these differences are discussed.

Adult↗
PubMed1990

Benzodiazepine use in a small community hospital. Appropriate prescribing or not?

Benzodiazepine (BDZ)-prescribing patterns in relation to indications and to drug characteristics in a small short-stay hospital were examined. In a sample of 800 patients, 183 were prescribed BDZs during their stay. Female patients received more BDZs (BDZ:female patients 1.31:1.0) than males (BDZs:male patients 1.02:1.0), particularly in the 21-40-year age group in which polypharmacy was highest. BDZs were classified according to their elimination half-lives. Our data showed that the majority fell into the long-acting (half-life greater than 24 h) (55%) and intermediate-acting (half-life 12-24 h) (20.7%) categories, despite the fact that most indications (pre-anaesthetic and night-time sedation; total 71.6%) called for the shorter-acting drugs. The merits or otherwise of this situation are discussed, and a number of questions put regarding the validity of this approach. Overall, BDZs accounted for 5.8% of the calculated medications given to the 800-patient sample.

Adolescent↗
PubMed1989

Treatment of narcolepsy with L-tyrosine: double-blind placebo-controlled trial.

A randomised, double-blind, placebo-controlled study of L-tyrosine was done in ten subjects with narcolepsy and cataplexy. Of twenty-eight visual analogue scales rating mood and arousal, the subjects' ratings in the tyrosine treatment (9 g daily) and placebo periods differed significantly for only three (less tired, less drowsy, more alert). Ratings of daytime drowsiness, cataplexy, sleep paralysis, night-time sleep, overall clinical response, and measurements of multiple sleep latency and tests of speed and attention did not differ significantly between tyrosine and placebo periods. Dietary supplementation with tyrosine 9 g daily for 4 weeks seems to have a mild stimulant action on the central nervous system but this effect is not clinically significant in the treatment of the narcoleptic syndrome.

Adult↗
PubMed1989

Relative efficacy of intravenous methylprednisolone and ACTH in the treatment of acute relapse in MS.

To compare the efficacy of high-dose intravenous methylprednisolone with intramuscular ACTH in the treatment of acute relapse in multiple sclerosis, we undertook a double-blind, randomized, controlled study involving 61 patients. There was a marked improvement in both groups in the course of the study, but no difference between them in either the rate of recovery or the final outcome. High-dose IV methylprednisolone is a safe alternative to ACTH in the management of acute relapse in MS.

Acute Disease↗
PubMed1989

Carbamazepine clearance in paediatric epilepsy patients. Influence of body mass, dose, sex and co-medication.

Carbamazepine clearance was studied in Black paediatric epilepsy patients, 90 receiving monotherapy and 17 on combination therapy. For patients on monotherapy the following relationship are shown: clearance decreases with increasing body mass (r= 0.87); clearance increases with increasing dose (r = 0.70); and mean clearance for male are higher than those for females throughout the mass ranges, though the difference is not statistically significant. In the case of patients on carbamazepine plus another anticonvulsant, clearance also decreases with increasing body mass, and increases with increasing dose. Furthermore, in the mass groups which corresponded with those on monotherapy, mean carbamazepine clearance higher by a factor varying from 1.3 to 1.7; in the corresponding dosage groups, it is higher by a factor of between 1.4 and 1.7.

Biological Availability↗
PubMed1988

Painful scoliosis secondary to an osteoid osteoma of the rib.

A 14-year-old girl with painful scoliosis was found to have an osteoid osteoma involving the body of the left seventh rib. Excision of the tumor was facilitated by intraoperative bone scanning that precisely located its position. Following surgery, preoperative pain was completely relieved and the spinal curvature had partially regressed. The importance of early diagnosis and excision of tumors is emphasized to prevent the establishment of a permanent structural scoliosis.

Adolescent↗
PubMed1987

Protein composition of the threat induced epidermal secretion from the Arabian Gulf catfish, Arius thalassinus (Ruppell).

1. When threatened or injured, the Arabian Gulf catfish (Arius thalassinus, Ruppell) secretes a thick gel-like layer of proteinaceous material to its skin surface mainly from unicellular glands of the epidermis termed club cells. 2. Since a preparation from this secretion has been implicated in stimulation of the rate of wound healing in man and other test animals, the total gel protein composition was analysed by chemical, chromatographic and electrophoretic techniques. 3. Gel proteins were separated into soluble and insoluble fractions by extractions with increasingly strong solubilizing agents and the most insoluble components were solubilized only upon treatment with 10% SDS or concentrated organic acids. 4. Some of the soluble proteins from the secretion are also present in the insoluble protein fractions, indicating that the insoluble material is formed in part by aggregation of the soluble proteins. 5. The secretion was shown to be distinct from the catfish venom and differed greatly from typical fish mucus secretions in its composition and distribution of protein components.

Amino Acids↗
PubMed1987

Omnipause neurons in two cases of opsoclonus associated with oat cell carcinoma of the lung.

Opsoclonus is an involuntary eye movement disorder in which there are chaotic, usually conjugate, multidimensional saccadic eye movements. In this paper 2 cases of opsoclonus are reported, as a paraneoplastic phenomenon in association with oat cell carcinoma of the lung. It has previously been hypothesized that opsoclonus results from dysfunction of a group of premotor neurons in the brainstem called omnipause neurons. We describe the location of these cells in man by homology with animal studies, and describe the light microscopic appearance of these neurons in the 2 cases of opsoclonus. Although these neurons appeared normal it is still possible that their function was disturbed as a result of metabolic or neurotransmitter abnormalities.

Aged↗
PubMed1986

Drug prescribing in paediatrics at a teaching hospital serving a developing community.

Drug prescribing for paediatric inpatients at a teaching hospital serving a developing community was investigated. A list of 695 patient record numbers was randomly generated from the 7637 children admitted over the period examined (9.1%). Prescribed drugs were computer-categorized and counted. Antibacterials (30.0%), vitamins, iron preparations and dietary supplements (20.0%), electrolytes (18.8%), analgesics (12.2%) and respiratory drugs (7.1%) comprised the most frequently-prescribed groups. The main (admitting) diagnoses of the sample were also classified. Infective diseases (42.0%), respiratory conditions (18.2%), perinatal disorders (14.9%) and nutritional deficiencies (9.9%) predominated. Data for individual drugs in the four dominant drug groups are presented. The margins between the top one or two drugs and the others in each therapeutic category are notable. Few drugs are extensively used. They include ampicillin, paracetamol, multivitamin syrup and Darrow's preparations. The implications of this picture in therapeutics are discussed.

Africa, Southern↗
PubMed1979

Pneumoperitoneum associated with artificial ventilation.

Four adults injured in serious road-traffic accidents developed pneumoperitoneum after artificial ventilation. No case could be attributed to injury or to perforation of a hollow viscus in the belly, but doubt about this in one patient resulted in exploratory laparotomy. In three patients the origin of intraperitoneal air was considered to be leakage through minute ruptures in alveoli subjected to the stress of artificial ventilation, with air tracking to the mediastinum, pleural space, subcutaneous tissues of the neck and chest, and peritoneal cavity. The fourth patient later developed herniation of the stomach through a rupture in the diaphragm, the presence of a pneumothorax on the same side suggesting direct passage of air through the diaphragm. Pneumoperitoneum induced by artificial ventilation is probably more common than reports suggest and should be distinguished clinically and radiologically from that caused by rupture or perforation of a hollow viscus. This will reduce the number of needles laparotomies performed on patients who are already seriously ill.

Adult↗