Medicine is always in some way an intervention. In old age one can usefully divide the rehabilitation intervention action in the following three groups: 1. The preventive rehabilitation by still healthy elderly persons to prevent the changes of old age. 2. The general rehabilitation by each elderly and ill person to keep the stay in bed as short as possible and to improve the independence of the patient and 3. the purposive rehabilitation by certain illness (hemiplegia) which mostly needs an entire treatening team. The rehabilitation keeps certain rules but it has to be individualised for each patient. Further the predominant principles are quoted, even though incomplet, after which the medical and social arrangements and services are bild on.

Aged↗

PubMedDate not supplied

Influence of bioflavonoids on lysosomal acid hydrolases and lysosomal stability.

In rats treated with (+)-catechin or 0-(beta-hydroxyethyl) rutosides, the activity of lysosomal acid hydrolase, namely, beta-glucuronidase, beta-N-acetyl glucosaminidase and cathepsin D in serum, liver and kidney and the stability of liver lysosomes was studied. The activity of these enzymes in bioflavonoids treated tissues and serum decreased significantly. Analysis of liver lysosome-rich fraction revealed an appreciable increase in the total activity and significant decrease in the rate of release of beta-glucuronidase in bioflavonoids treated animals. The results may, therefore, suggest stabilization of lysosomes due to the administration of bioflavonoids.

Acetylglucosaminidase↗

PubMedDate not supplied

Influence of bioflavonoids on the collagen metabolism in rats with adjuvant induced arthritis.

In rats with adjuvant induced arthritis, the effect of CA or HR on the metabolism of collagen in skin was studied. In untreated animals with adjuvant induced arthritis, the synthesis of collagen is decreased, the catabolism of newly formed collagen is intensified and the conversion of soluble collagen to insoluble collagen is impaired. Bioflavonoids were found to increase the collagen synthesis, accelerate the conversion of soluble collagen to insoluble collagen and inhibit the catabolism of soluble collagen. The beneficial action of bioflavonoids on the metabolism of collagen in adjuvant induced arthritis was discussed.

Animals↗

PubMedDate not supplied

Influence of bioflavonoids on the metabolism and crosslinking of collagen.

The influence of (+)-catechin (10 mg/100 g daily) and 0-(beta-hydroxyethyl) rutosides (50 mg/100 g daily) on the metabolism and crosslinking of collagen was studied in male albino rats. Compared to controls, the total activity of 3H-hydroxyproline in the dermal soluble collagen did not differ appreciably while the urinary total activity of 3H-hydroxyproline was significantly lowered. When the total activities of both soluble and insoluble collagens are expressed as a percentage of the sum of both, the registered activity was less in soluble and more in salt-insoluble collagen at 12 ans 120 h after the administration of 3H-proline in the treated group. Bioflavonoids were found to decrease the reversibility of neutral salt-soluble collagen gel and solubility of acid-insoluble collagen to denaturing agents. The subunit pattern of neutral salt-soluble collagen on sodium dodecylsulphate polyacrylamide gels revealed a decrease of alpha/beta ratio in bioflavonoids treated animals. The results of the present study indicate that the synthesis of collagen is unaffected, the crosslinking of collagen is promoted and the degradation of soluble collagen is decreased in the bioflavonoids treated groups.

Animals↗

PubMedDate not supplied

Mild dental findings associated with severe osteogenesis imperfecta due to a point mutation in the alpha 2(I) collagen gene demonstrate different expression of the genetic defect in bone and teeth.

Serial intraoral photographs, radiographs, and ground sections from an extracted upper permanent canine served to characterize dental abnormalities in a 15-year-old girl suffering from severe (type III) osteogenesis imperfecta (OI) due to a point mutation that substituted glycine 688 of the alpha 2(I) chain of collagen I by serine. Dental records showed that all deciduous teeth exhibited clinical and radiographic characteristics of dentinogenesis imperfecta (DI), whereas permanent teeth including the removed canine appeared normal, although pulp chambers contained unusually large denticles. Despite the unconspicuous clinical appearance of the canine, histologic sections revealed small, canal-like, hypomineralized hard tissue patches that lacked a regular tubular structure and occupied a narrow band of the bulk of normal circumpulpal dentin at about the level of the cemento-enamel junction. The finding that a mutation in the gene for the alpha 2(I) collagen chain with serious consequences in bone has only minor effects in teeth would suggest that odontoblasts, unlike osteoblasts, can largely compensate for this particular genetic defect, possibly by excluding the abnormal alpha 2(I) chains and forming alpha 1(I) homotrimeric collagen I. The discrepant consequences in deciduous as opposed to permanent teeth and the specific localization of the dentinal abnormalities in permanent teeth lead us to speculate that the exclusion of defective alpha 2(I) chains could depend on the developmental stage and/or the rate of extracellular matrix formation.

Adolescent↗