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B Stamm

Publications and source records attributed to B Stamm.

At least 73 records · Page 4Linked to original sources
PubMed1985

[Pathology of gastric mucosa polyps].

More frequent use of the endoscope to remove gastric mucosal polyps has also led to better knowledge of the pathology of these polyps. Their classification is still a matter of debate, and hence, by way of introduction, the notions of hyperplastic, hyperplasiogenous and hyperplastic-adenomatous polyp, adenoma, borderline lesion protruded type, foveolar hyperplasia and cysts of the gastric glands are presented. The authors give preference to the WHO classification of 1977. Among 196 mucosal polyps examined between 1970 and 1982 84% were hyperplastic (hyperplasiogenous) polyps, 15.5% adenomas and there was a single specimen of hamartomatous polyp. One in every 6 adenomas showed malignant changes and 5 of the 165 hyperplastic polyps were associated with gastric carcinoma. Problems of diagnosis, classification and prognosis are briefly discussed.

Adenoma↗
PubMed1985

[Primary colon tuberculosis].

Two cases of primary gastrointestinal tuberculosis are reported. One patient showed radiologic, colonoscopic and histopathologic features of Crohn's disease. After a five-year follow-up, acid-fast bacilli were identified in colonic tissue cultures. In both patients fecal cultures were repeatedly negative for Mycobacterium tuberculosis. The two patients were successfully treated with antituberculous therapy. The authors emphasize the importance of considering tuberculosis in patients presenting with Crohn's disease. In this regard colonoscopy with tissue culture of targeted biopsy may be a valuable aid in establishing the diagnosis of tuberculous colitis.

Adult↗
PubMed1985

Endoscopic removal of a large, obstructing and bleeding duodenal Brunner's gland adenoma.

About 10-30% of benign duodenal tumors are Brunner's gland tumors. These are almost always benign. Usually they present as incidental findings in the form of small polypoid lesions at barium examination or at panendoscopy. We present a case with a large obstructing and bleeding Brunner's gland adenoma located in the duodenal bulb which was removed by endoscopic polypectomy.

Adenoma↗
PubMed1985

Mucosal biopsy of vascular ectasia (angiodysplasia) of the large bowel detected during routine colonoscopic examination.

Between 1975 and 1983, 9434 colonoscopic examinations were performed at the University Hospital of Zürich. Localized vascular ectasia was detected in 84 patients and there were 48 mucosal biopsies from 46 patients. From the total of 48 biopsies only 24 (50%) showed vascular anomalies. The most frequent lesion encountered was groups of thin-walled dilated vessels in the lamina propria seen in 21 biopsies from 20 patients. These dilated vessels are not specific but in respect of age (median 69 years), location (predominantly in the caecum and the ascending colon) and frequent multiplicity, they are suggestive of angiodysplasia. Five of the 20 patients suffered from chronic anaemia due to haemorrhages. The three other positive biopsies (from two patients) revealed a tiny haemangioma in the sigmoid colon of a 28-year-old woman and a few large, thick-walled probably malformed vessels in the mucosa of the caecum of a 17-year-old boy. Twenty-four biopsies did not show any histologically significant vascular anomaly. Mucosal biopsy of vascular lesions detected during routine colonoscopic examination will, if positive, most frequently simply confirm the endoscopically diagnosed vascular ectasia and may in rare cases show or alert suspicion to vascular lesions other than angiodysplasia. Definitive morphological diagnosis will however only rarely be achieved by this method of investigation.

Cecum↗
PubMed1984

[Cystic neoplasms of the pancreas. Pathologico-anatomic study of 15 pancreatic tumors].

Cystic neoplasms of the pancreas are rare and comprise about 2% of all exocrine tumors. Clinically they manifest as an abdominal mass and may result in gastrointestinal or biliary obstruction or remain symptomless. Fifteen such tumors from the Institute of Pathology, University Hospital, Zürich, are presented. Eleven of them are autopsy findings and 4 are operative specimens. They can be divided into two distinct groups described as (A) microcystic adenomas, composed of many small cysts lined by cuboidal cells containing glycogen but no mucin, and (B) as mucinous cystic tumors formed by larger cystic spaces lined by tall, columnar, mucin-producing cells. Microcystic adenomas are invariably benign, whereas the majority of mucinous tumors show focally malignant epithelium. We had no difficulty in distinguishing between these two forms. Nine of the 11 microcystic adenomas were autopsy findings, and we have follow-up information only for two patients. Histologically, however, no malignant change was seen in a microcystic adenoma but was found in 3 of the 4 mucinous tumors. The cell of origin of the mucinous tumors must be the lining cell of the excretory ducts. Because of histological and ultrastructural similarity, the cell of origin of the microcystic adenoma is thought to be the centroacinar cell. The question arises whether these latter tumors, not infrequently combined with cysts or cystic tumors in other organs, should not rather be classified as hamartomas.

Adenocarcinoma↗
PubMed1983

Small pedunculated tubular adenoma of the colon with carcinoma restricted to the head, invasion of lymphatics and widespread metastases. Case report and review of the literature.

The case of a 66 year old woman who died of metastatic adenocarcinoma is reported. The origin of the tumor was found at autopsy to be a focal carcinoma in the head of a small pedunculated tubular adenoma at the recto-sigmoidal junction. Nine similar case reports from the literature are briefly presented.

Adenocarcinoma↗
PubMed1979

[Experiments for the development of a hepatitis B vaccine: immunogenicity of HBsAg in guinea pigs (author's transl)].

Hepatitis B surface antigen (HBsAg) was purified from human plasma by gel chromatography, isopyknic centrifugation, and zonal centrifugation. The final product had about 60% of the original activity and was essentially free from hepatitis B virus particles (HBV) and plasma proteins. Treatment with formaldehyde concentrations up to 0.1% for inactivation of residual infectivity did not significantly reduce antigenicity in vitro and immunogenicity in guinea pigs. Adsorption to aluminum hydroxide resulted in 16-fold higher concentrations of antibody against HBsAg (anti-HBs) than did injection of soluble HBsAg. After two injections of 0.2 microgram HBsAg, which was treated with 0.1% formaldehyde and absorbed to aluminum hydroxide, the median titer of anti-HBs in guinea pigs was 4 IU/ml (normal value in human hepatitis B convalescents: about 0.1) for 1 year without further injections. When guinea pigs received 12 equivalents of homologous anti-HBs serum before the first injection of adsorbed HBsAg, the same anti-HBs titers were found after the booster injection as in animals which had not been passively immunized. A simultaneous application of an experimental HBsAg vaccine and hepatitis B immunoglobulin would probably decrease the potential risk of HBV infections caused by the vaccine itself and also produce rapid protection. To establish absence of HBV as completely as possible, the vaccine should be produced from anti-HBe-positive plasma by efficient purification procedures and it should be inactivated by formalin.

Aluminum Hydroxide↗
PubMed1979

[Prognosis of intensively treated newborns: psychomotor development during the first years of life].

330 out of 616 surviving newborns treated in the neonatal ICU of Berne University Children's Hospital from 1.1 1974 to 31.12. 1976 were considered, on the basis of strict criteria, to be especially at risk for the development of abnormal cerebromotor symptoms, 287 were followed up. At age 3--42 (mean 15) months, 10% of these especially endangered children showed clear-cut, and 24% slightly abnormal, symptoms. If related to the total number of surviving patients, all of whom were either ill or at risk for disturbed neonatal adaptation, this corresponds to 5 and 11% respectively. Based on this population, an approximate incidence of cerebral palsy of 5% at age 15 months can be calculated for the whole pediatric population. This value is comparable to the 2% actually found in the total pediatric population. Furthermore, a statistically significant decrease in abnormal symptoms with increasing postnatal age was found. Newborns with convulsions, however, do not have this favourable prognosis.

Asphyxia Neonatorum↗
PubMed1978

[Gas gangrene. The files of the Swiss Accident Insurance Company 1963-1975].

The clinical histories of 28 cases registered as gas gangrene by the Swiss National Accident Insurance (Schweizerische Unfallversicherungsanstalt) from 1963 to 1975 are reviewed. According to the classification of Altemeier (1. gas gangrene, 2. clostridial cellulitis, 3. simple contamination of a wound by Clostridium, and 4. gaseous infection without Clostridium) only 5 cases were assignable to group one (1 survivor), 2 cases to group two, 9 to group three and 9 to group four. Typical cases from each group are discussed to illustrate the advantages of this classification, the dangers of treatment based on wrong diagnosis, and the necessary prophylaxis. The more serious prognosis in gas gangrene in comparison to the other groups is emphasized.

Accidents, Occupational↗
PubMed1978

[Asymptomatic chronic-persisting hepatitis B in a young child as source of infection of hepatitis B within a family (author's transl)].

Five members of an eight-member family fell ill with an acute icteric hepatitis B of the same subtype within eleven months. In all probability the source of the infection was a just over one-year-old fostered child with asymptomatic chronic persisting hepatitis B and signs of massive viraemia (usually high HBs antigen concentration, high virus-specific DNA-polymerase activity and positive HBe antigen test). No relation could be demonstrated between HLA constellation and illness in the family members. Since no specific treatment is available, the only possible prophylactic measure is to isolate the child in the present environment, to avoid further cases of the disease.

Acute Disease↗
PubMed1978

[Differing results of direct and indirect solid phase radioimmunoassay for HBsAg in acute hepatitis (author's transl)].

In 54 patients suffering from acute viral hepatitis the indirect solid phase radioimmunoassay (ind-SPRIA) for HBsAg was positive in 9 cases the direct solid phase radioimmunoassay (d-SPRIA) being negative. In 2 further cases ind-SPRIA was positive during several weeks but d-SPRIA only once. AntiHBc could be detected in 9 of these patients. In 7 patients the usual decrease of the transaminase activity was followed by a second elevation with prolongation of disease. The unknown factor detected by ind-SPRIA suggests a special form of acute hepatitis.

Adult↗