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Biomedical subjects

B Staberg

Publications and source records attributed to B Staberg.

At least 55 records · Page 3Linked to original sources
PubMed1984

Postinflammatory oedema in two patients with contact dermatitis. Effect of benzo-pyrones.

Two female patients with oedema of the arms and legs due to contact dermatitis complicated with recurrent infections were examined. The concentrations of plasma proteins of different molecular weight in the oedema fluid (collected from suction blisters) were highly increased. Albumin outflux as measured with radiolabelled albumin from the vessels of oedematous skin was markedly decreased corresponding to a decreased lymphatic function. Treatment with benzo-pyrones for 6 months did reduce the protein concentrations of the oedema fluid, but the clinical response was disappointing.

Albumins↗
PubMed1984

Paroxysmal dysarthria and Raynaud's phenomenon in the tongue.

Three patients suffering from systemic scleroderma and Raynaud's phenomenon in the digits as well as the tongue are reported. Following exposure to cold, a vasospasm was observed in the digits and the tongue accompanied by severe dysarthria. These striking oral symptoms had been overlooked for years in the medical ward. It is recommended to question all patients with Raynaud's phenomenon about visceral manifestations during the digital attacks.

Aged↗
PubMed1983

Sun beds.

Explore the source record for details and available documents.

Animals↗
PubMed1983

Skin vessel leakage of plasma proteins after PUVA therapy.

In eight healthy volunteers the effect of PUVA therapy on skin vessel leakiness was examined (a quadrant on one side of the abdominal skin was shielded during the UVA irradiation). The relative concentration of intravenously injected labeled albumin in suction blister fluid from irradiated skin was only slightly elevated 2 days after PUVA treatment, whereas a significant elevation (P less than 0.01) was observed on non-irradiated skin. No significant changes were observed in the concentrations of four endogenous plasma proteins in serum and blister fluid. It is concluded that PUVA therapy can induce an increased vascular leakage of albumin from the skin vessels due to humoral factors. In exposed--in contrast to non-exposed--skin, the findings are influenced by an interstitial oedema.

Adult↗
PubMed1983

Lymphatic albumin clearance from psoriatic skin.

In nine patients with untreated psoriasis vulgaris, human serum albumin labelled with 125I or 131I was injected intradermally in symmetrically located involved and uninvolved skin. The activity of the depots was followed by external detection, and the arrival of labelled albumin in plasma was monitored. In involved psoriatic skin the local mean half-time (T1/2) for tracer disappearance was 20.8 +/- 8.2 (S.D.) hr and in clinically normal skin, 29.1 +/- 9.6 (S.D.) hr. The difference was significant (p less than 0.002). Accordingly, the tracer from involved skin reached higher plasma levels than the tracer from uninvolved skin. However, under slight lymphatic stasis the appearance rate of radiolabelled albumin in plasma from both tissues was minimal during 1 to 2 hours after the injection, indicating that a local direct transvascular drainage of plasma albumin from the interstitium of diseased and normal skin was negligible. We conclude that the previously demonstrated increased extravasation of plasma proteins in involved psoriatic skin is compensated by an increased lymphatic drainage of plasma proteins, and not by an increased local transvascular return.

Adult↗
PubMed1983

Cutaneous blood flow in psoriasis.

The disappearance rate of 133Xe was studied in 20 patients with psoriasis vulgaris, using an epicutaneous labeling technique in involved skin lesions or normal-appearing skin of the proximal extensor site of the forearm. Control experiments were performed in 10 normal subjects. Calculations of the cutaneous blood flow (CBF) in psoriatic skin lesions were performed using a tissue-to-blood partition coefficient for 133Xe, lambda c,pso, of 1.2 ml/100 g/min. lambda c,pso was estimated after the relative content of water, lipids, and proteins had been analyzed in psoriatic skin biopsies of 6 patients with untreated psoriasis. The mean relative content of water was markedly reduced to 23.5 +/- 1.5% (SEM), and lipids and proteins were markedly increased to 2.5 +/- 0.7% and 74.0 +/- 2.2, respectively, compared to previously published data for normal skin (water 72.5%, lipids 1%, proteins 26.5%). Mean CBF in untreated psoriatic skin was 63.5 +/- 9.0 ml/100 g/min. This was significantly higher than the mean CBF in 10 normal subjects, 6.3 +/- 0.5 ml/100 g/min (p much less than 0.0001). Mean CBF in normal-appearing skin in patients with psoriasis was 11.0 +/- 1.3 ml/100 g/min. This was significantly higher than CBF in normal subjects (p less than 0.0002).

Adult↗
PubMed1983

The carcinogenic effect of UVA irradiation.

The carcinogenic effect of UVA radiation (from Philips black light tubes filtered through a 2 mm-thick glass plate to eliminate the radiation below 320 nm) was studied in 7 groups of 25 lightly pigmented hairless mice. Irradiation with a moderate daily dose of combined UVB and UVA for 3 months induced a tumor incidence of 0.22 after 58 weeks. When the combined UVB and UVA irradiation was followed by filtered UVA for 2, 4, or 6 months, the tumor incidence was marginally significantly increased to 0.42, 0.48, and 0.50 (p less than 0.05), respectively. However, irradiation with the moderate dose of combined UVB and UVA induced a slight but not significantly lower tumor incidence as compared to UVB alone (0.22 vs 0.30, p greater than 0.1). UVA alone induced no tumors. It thus appears that in hairless mice initially exposed to a combination of UVB and UVA, subsequent continued irradiation with UVA increases tumor incidence. While only marginally statistically significant, tumor incidence in these animals seems to increase with duration and hence total UVA exposure. Furthermore, it is suggested that the photoaugmentative carcinogenic effect of UVA irradiation from unfiltered UVA bulbs can be reduced by attenuating the shorter wavelengths of the radiation.

Animals↗
PubMed1983

Comparison of portable CdTe(Cl) detectors with stationary NaI(Tl) detectors for subcutaneous 133Xe disappearance measurements.

133Xe washout measurements from locally injected depots in the subcutaneous tissue of the thigh have been performed intermittently by a NaI(Tl) detector placed 15 cm from the depot and a cadmium telluride [CdTe(Cl)] detector fixed to the skin surface above the depot. In 19 experiments, the measurements were performed during rest, before and after bicycling and during circulatory arrest during an occlusion cuff pressure of 240-250 mmHg. The disappearance rates measured by the two detector systems showed a linear correlation (r = 0.934, P less than 0.001). However, the rate constants measured by the CdTe(Cl) detector were an average of 1.48 times the values obtained by the NaI(Tl) detector during a period of 1-4 h after the injection. The coefficient of variation of the proportionality factor is 3.3%. Only the central part of the local depot area is exposed to the CdTe(Cl) detector. Using the NaI(Tl) detector and lead shielding of the peripheral or central part of the depot area, it was demonstrated that the disappearance rates obtained reflect the measuring geometries. The correction itself is therefore due to differences in the measuring geometries of the two detector types, and possibly to diffusion and convection of xenon. For quantitative determination of the subcutaneous blood flow, the disappearance rate constants determined by the CdTe(Cl) detector thus have to be corrected by division with the factor 1.48.

Adolescent↗
PubMed1983

Passage of albumin from plasma to suction skin blisters.

To study the transvascular passage of albumin from the plasma to the skin interstitium, suction blisters were developed on the abdominal skin of six young, healthy male volunteers. Fifteen minutes after the blisters had been formed and the suction had been stopped, 125I-albumin was injected intravenously and the disappearance of the tracer protein from plasma was compared to its appearance in blister fluid as a function of time for up to 4 h after the injection. There was a linear increase of blister fluid activity with time after injection and the mean accumulation rate of the six subjects was 0.9 +/- 0.4 (SD)%/h. It is suggested that this figure is a representative measure of the leakage of albumin through the skin microvasculature. In previous studies, a ten-fold higher accumulation rate of albumin was found when the protein tracer was administered intravenously before the suction was induced. This difference was probably due to a suction-induced increase of the filtration gradient across the skin vessels. It is concluded that both methods might be used to obtain a comparative measure of the local rate at which albumin passes from plasma to the interstitial fluid of the skin.

Adult↗
PubMed1983

Locally injected bleomycin in the treatment of warts.

To evaluate the clinical effectiveness of intradermally injected bleomycin in saline and oil versus placebo, a double-blind study of 62 patients with 108 warts was made. Although bleomycin has been recommended in previous reports, we found no difference between the group treated with bleomycin and the placebo group.

Bleomycin↗
PubMed1983

Successful treatment of cold angio-oedema by H2-antihistamine therapy.

Two patients with severe cold angio-oedema were practically relieved from their symptoms during H2-blocker therapy (cimetidine 1 000 mg daily). Classic H1-blocker therapy had no effect on their symptoms and combined H1- and H2-blocker treatment was just as effective in ameliorating the symptoms of cold angio-oedema as H2-blocker treatment alone. A low dose of the H2-blocker (400 mg cimetidine daily) was almost able to control the angio-oedema formation after cold exposure, but provoked typically urticarial lesions. This observation strongly indicates that H2-receptors may play an important role in the pathogenesis of cold angio-oedema and that a massive, subcutaneous, cold angio-oedema may obscure cold urticarial lesions.

Adult↗
PubMed1983

Onychomycosis in patients with psoriasis.

The frequency and type of fungal infections of the finger- and toenails was studied prospectively by direct microscopic and culture examinations in dermatological out-patients without psoriasis (n = 41), in patients with psoriasis but no nail involvement (n = 39), and in patients with both psoriasis and nail involvement (n = 39). In these three matched groups the frequencies of dermatophytic nail infections were 10%, 13%, and 13%, respectively, and the frequencies of yeast infections 10%, 10%, and 15%, respectively. These figures were not significantly different. It is concluded that dermatophytic invasion of involved psoriatic nails is not so rare as previously supposed. However, yeast infections are possibly more frequent in involved psoriatic nails as compared with uninvolved and normal nails.

Humans↗
PubMed1983

Reduced blood flow in fibromyotic muscles during ultrasound therapy.

The muscle blood flow (MBF) in m. trapezius was studied in 7 subjects with fibromyotic pain syndrome before and during treatment with ultrasound (1 Watt/cm2) and during placebo treatment, using the local 133Xe-washout technique. MBF in the fibromyotic muscles was significantly reduced during ultrasound treatment (p less than 0.05) compared to the blood flow before the treatment and during placebo treatment 1.57 +/- SEM 0.52 and 2.51 +/- SEM 0.43 ml/100 g/min, respectively. In 6 normal trapezius muscles the mean MBF was 2.30 +/- SEM 0.44 ml/100 g/min before ultrasound treatment and 2.31 +/- SEM 0.41 ml/100 g/min during ultrasound therapy. MBF decreased in a lidocaine blocked fibromyotic muscle during ultrasound treatment while no effect on MBF was detectable during ultrasonic treatment a normal lidocaine pretreated muscle. It is concluded that ultrasound treatment decreases MBF in fibromyotic muscles and that this is paradoxical effect of ultrasound might be due to a direct effect on the vessels or a local release of vasoactive substances in the fibromyotic muscles.

Humans↗