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Biomedical subjects

B Sokoloff

Publications and source records attributed to B Sokoloff.

18 recordsLinked to original sources
PubMed2001

Fixed minidose versus-adjusted low-dose warfarin after total joint arthroplasty: a randomized prospective study.

Widespread use of adjusted low-dose warfarin has been limited by the inconvenience of outpatient laboratory monitoring and the perceived risk of bleeding complications. We sought to determine if the dose of warfarin could be lowered safely even further, eliminating the need for laboratory monitoring and lowering the complication rate. Two hundred forty-five Patients undergoing primary total joint arthroplasty (n = 245) were randomized prospectively to adjusted low-dose warfarin (international normalized ratio [INR], 1.4-1.8) or fixed minidose warfarin (2 mg daily, regardless of INR) before hospital discharge. Prophylaxis continued for 6 weeks, with twice-weekly laboratory monitoring. Patients were followed for bleeding, thromboembolic events, and minor reported complications of warfarin therapy. With the numbers available, the rates of thromboembolic and bleeding events were not significantly different using equivalence analysis. Of patients in the fixed group, 8% had INRs >3.1, necessitating a decrease in dosage to 1 mg. Although such a fixed-dose protocol may simplify outpatient prophylaxis, intermittent monitoring still would be required because a subset of patients achieve a moderate level of anticoagulation and would be at risk for bleeding complications.

Adult↗
PubMed1984

Five-year follow-up of Vietnamese refugee children in the United States.

The purpose of this study was to investigate the present physical, mental, and psycho-social health of Vietnamese refugee children. Questionnaires were sent or given to adoptive families, foster families, and Vietnamese children living in the United States with their family units. Otitis media, respiratory ailments, and varicella constituted a large number of their initial medical problems. Severe nightmares and temper tantrums occurred frequently during their first year. It was found that the children's health and emotional problems improved markedly after the first year. Despite stormy pasts, present social and school problems are minimal, and some children appear to be high achievers. Most of the Vietnamese children, especially those who were adopted, are doing much better than we anticipated. Advance preparation and guidance given by the involved agencies appear to be of significance in achieving these excellent results.

Adaptation, Psychological↗
PubMed1979

Adoptive families. Needs for counseling.

Adoption is an on-going process which affects each member of the adoptive family during each phase of the adoptee's maturation. Specific factors, such as insecurities of the adoptive parents, the child's awareness of his adoption in relation to his age and fantasies, and recently, the introduction of the possibility that the adoptee may arrange to meet his birth-parents later in life tend to add more perplexities to problems existing in these families. The normally turbulent age of adolescence increases anxieties in these vulnerable families. The pediatrician must understand the various factors uniquely inherent in adoption so that he can more effectively provide counsel to these patients.

Adolescent↗
PubMed1976

Relationship of allergy, enuresis, and urinary infection in children 4 to 7 years of age.

A group of 234 children, 4 to 7 years old, in a middle- to upper-middle-class Caucasian population, were divided into four groups and matched for age and sex. Group 1 consisted of 50 children previously treated for urinary infection: control group 1 contained 55 well children; group 2 consisted of 69 children treated for respiratory allergy; and control group 2 contained 60 well children. There was no statistical difference in persistent enuresis (night wetting every week), persistent day wetting (every week), allergy, or family history of enuresis, when group 1 and control group 1 were compared. A family history of urinary infection was higher (P less than .05) in group 1. There was no statistical difference in persistent enuresis, persistent day wetting, previous urinary infection, or family history of enuresis or urinary infection when group 2 and control group 2 were compared. This study suggests that there is no relationship between respiratory allergy, enuresis, and urinary infection.

Child↗
PubMed1976

Chemotherapy on Harding-Passey melanoma with gladenine. Part I.

The effect of Gladenine, an oncolytic antibiotic produced by a newly discovered fungus, Paecilomyces todicus, nov. sp. was investigated on Harding-Passey, hard tumor, melanoma. A long-term screening technique was used in the investigation. 15 mg/100 gm. wt/mouse was injected I.P. starting 10-14 days after transplant, when all tumors were well pronounced, and continuing for 18-34 days. The majority of mice did not lose weight. Tumors were absent on the average in about 33% of the mice and average T/C was .16. Combining Cladenine with Hydrazine sulfate, either 1.5 mg. or 2.5 mg./100 gm. wt./mouse, using the same screening technique, resulted in 60-100% of mice free of tumors, and still remaining so several months later. Average T/C was .06. Combined therapy with Gladenine and Hydrazine sulfate at 3.75 mg./100 gm. wt./mouse gave less satisfactory results. Repeated screening tests using the same long term techniques, gave similar or identical results. It appears that Harding-Passey melanoma is susceptible to the chemotherapy of Gladenine alone and/or combined with small doses of Hydrazine sulfate.

Animals↗