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Biomedical subjects

B Sinkovic

Publications and source records attributed to B Sinkovic.

24 records · Page 2Linked to original sources
PubMed1978

The pathogenesis of infectious avian encephalomyelitis. 4. The effect of maternal antibody on the development of the disease.

Infectious avian encephalomyelitis virus (IAEV) maternal antibody was detected in the serum of chickens for up to 21 days following hatching. This antibody protected chickens against clinical IAE after intracerebral inoculation with van Roekel strain or oral administration of the NSW-1 strain of IAEV. Maternal antibody to IAEV also protected testosterone bursectomised chickens against the development of clinical disease. IAEV maternal antibody also influeced the pattern of virus excretion in faeces and serological responsiveness. This influence on antibody responses persisted beyond the time that IAEV maternal antibody could be detected. The importance of IAEV maternal antibody on the strategy of vaccination against IAE is discussed.

Age Factors↗
PubMed1976

Field trials with lyophilised herpesvirus of turkeys vaccine against Marek's disease in layer and broiler rearing flocks.

The safety and immunogenicity of commercial lyophilised herpesvirus of turkeys (HVT) vaccine against Marek's disease (MD) was evaluated in 19 field trials involving 76,848 vaccinated and 87,590 control chickens. In the first series of 11 trials involving one commercial vaccine at a dose of 536 plaque forming units (PFU) there was a significant reduction in the incidence of MD (P less than 0.001) and in total mortality (P less than 0.001) from 0 to 18 weeks due to vaccination and the overall protection was 85.2%. In the second series of eight trials involving another commercial vaccine at a dose range of 1360 to 1900 PFU there was a significant reduction in the incidence of MD (P less than 0.001) from 0 to 18 weeks of age due to vaccination. The overall protection was 77.8%. In both series there was a significant difference in MD mortality between meat breeders and crossbred pullets (P less than 0.005) in response to vaccination. There was also a significant difference in total mortality from 0-6 weeks of age between the two series suggesting either differences in response to the two vaccines or differences in the vaccination technique. In a number of trials the incidence of MD was low in the controls, however, where MD incidence was above 2% in the controls protection usually exceeded 80%. It was concluded the vaccines were safe and efficacious and the degree of protection was comparable to that obtained by HVT vaccines described in other countries.

Animals↗
PubMed1976

The immunisation of chickens against infectious avian encephalomyelitis.

An immune response was induced in chickens vaccinated with the NSW-1 virus by the intramuscular, eye drop, wing web or oral methods. The oral procedure was the most sensitive in inducing an immune response with the lowest dose of virus. The wing web method was the least sensitive. Clinical IAE developed in 1 chicken following intramuscular vaccination. The virus was recovered from the faeces of chickens vaccinated orally with 700 CID50 of the virus from the third to the tenth day after vaccination.

Administration, Oral↗