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Biomedical subjects

B Singh

Publications and source records attributed to B Singh.

At least 1,099 records · Page 61Linked to original sources
PubMedDate not supplied

Inactivation of clinical isolates of Herpesvirus hominis, types 1 and 2, by chemical contraceptives.

Two chemical contraceptives were examined for virucidal effects against four strains each of Herpesvirus hominis, type 2 and 1. Seven of the strains represented recent clinical isolates; one strain was a type 2 prototype. Either psermicide reduced the infectivities ofall eight viruses after contact for 10 minutes at room or body temperature. The new spermicide-germicide, compound A, produced an antiviral effect at the low concentration of 0.05%, whereas the commercially available Preceptin was effective at 5%, but not at 0.5%. The substantial loss of viral infectivity was due to direct inactivation of virus by the spermicides and was not secondary to cytotoxicity or induction of interferon in the cell cultures used for the assay. These in vitro findings hold primse for the interruption of the sexual transmission of H. hominis.

Cytopathogenic Effect, Viral↗
PubMedDate not supplied

Orbital myiasis--a case report.

A case of basal cell carcinoma presenting in an unusual manner as orbital myiasis is reported. Orbit was full of maggots. Histopathology examination from the margin of the ulcerative area confirmed the diagnosis of basal cell carcinoma, which was infested secondarily with larvae of flies. Turpentine oil packs were used to remove the maggots.

Aged↗
PubMedDate not supplied

Clinical and histologic findings of the dentition in a hypopituitary patient: report of case.

Idiopathic hypopituitarism is associated with delayed dental eruption as well as delayed growth of the dentofacial complex. Both maxillary and (especially) mandibular growth can be affected. The clinical dental findings and histologic findings related to enamel maturation in the permanent dentition of a teenaged male with a hypopituitary condition are described.

Adolescent↗
PubMedDate not supplied

Hydrophobic amino acid residues in peptide antigens determine the genetic control of immune responses.

The ability to respond to an antigen is generally controlled by the activation of T helper cells. These cells are required for the initiation of immune responses including the activation of T effector cells in cell-mediated immunity and for the production of antibodies by B cells. Major histocompatibility complex (MHC) molecules present antigenic fragments to helper T cells, and recent studies suggest antigen binds to MHC molecules during this process. Both the composition and the structure of the peptide antigen and its ability to interact with MHC molecules determine the genetic responsiveness of an individual. We used a panel of synthetic polypeptide antigens with the repeating sequence Glu-X-Ala to determine the role that individual amino acid residues play in the recognition of antigens by T cells. The aromatic hydrophobic residues Tyr and Phe in polypeptide antigens Poly EYA, Poly EFA, and Poly EYAEFA were found to determine the genetic control of immune responses. Mice of H-2b,d haplotypes are high responders to Poly EYA, mice of H-2p,q haplotypes are high responders to Poly EFA and mice of H-2b,d,p,q strains are high responders to Poly EYAEFA. Mice of H-2k haplotype were nonresponders to all of these antigens. The antigen Poly ESA containing the hydrophilic residues (Ser), on the other hand, was found to be nonimmunogenic. Animals which are nonresponders to Poly EYA or Poly EFA, when primed with Poly EYAEFA, produce both T cells and antibodies which crossreact with Poly EYA and Poly EFA.(ABSTRACT TRUNCATED AT 250 WORDS)

Amino Acid Sequence↗
PubMedDate not supplied

REM sleep deprivation and food intake.

The effect of REM-sleep deprivation (REM-SD) on diet preference was studied in rats. REM-SD for a period of 72 hrs produced an increase in day, night and 24 hrs (day plus night) intakes of Carbohydrate Rich diet (CRD) and Total diet (TD). Body weight (BWt) was also increased. The maximum increase in the above parameters were recorded on the 2nd day of REM-SD. During recovery period the intakes of TD fully recovered, but the BWt and consumption of CRD remained high. Intakes of Balanced diet (BD) remained significantly on the lower side when compared to the pre REM-SD mean values. During REM-SD, the rats preferred CRD than BD. The body temperature did not show any change. The increase in TD intake and BWt could be the result of an increase in insulin level and the change appears to be mediated by the activation of hypothalamic feeding centre.

Animals↗
PubMedDate not supplied

Grave's disease. Appearance in cytologic smears from fine needle aspirates of the thyroid gland.

The cytomorphologic features were analyzed in thyroid samples obtained by fine needle aspiration (FNA) from 54 cases proven to be Grave's disease (toxic goiter) by a multiparameter study. A fire-flare appearance of the follicular cells and a good cellularity of the smears were the features most frequently observed in these cases. Hürthle cell changes were present in 47% of the cases, and small numbers of lymphocytes were seen in smears from 41% of the cases. Epithelioid cell granulomata and multinucleated giant cells were observed in less than one-fourth of the cases. About half of the cases showed some degree of pleomorphism of the follicular cells. Twenty cases of toxic multinodular goiter were similarly analyzed; the features that distinguished this entity from Grave's disease were the absence of epithelioid cells and multinucleated giant cells in the FNA smears.

Adult↗
PubMedDate not supplied

Correlation of preoptic neuronal activity with spontaneous and induced cortical EEG changes.

Preoptic area has neurons which change their firing rate along with spontaneous alterations of the cortical EEG between synchronization and desynchronization. The cortical EEG synchronization and desynchronization could be induced by stimulation of the caudal and the rostral brain stem respectively. This study was aimed at finding out whether stimulation of the brain stem structures produce the same change in the unit activity as that occurring during spontaneous alteration of the EEG. The changes in unit activity showed some concordance and dissociation between spontaneous and induced EEG alterations. The possible interaction of inputs from cortex and brain stem at the level of the preoptic area is discussed.

Animals↗
PubMedDate not supplied

Thermal changes produced by norepinephrine application in the preoptic area of monkeys.

The effect of injection of norepinephrine in the anterior regions of hypothalamus on rectal temperature, skin temperature, heart rate and respiratory rate in rhesus monkeys was studied. The injection of 2 micrograms of norepinephrine in the preoptic area produced a fall in body temperature without any accompanying change in skin temperature, heart rate and respiratory rate. The findings suggest that the suppression of heat production may be responsible for the norepinephrine induced hypothermia in monkeys.

Animals↗
PubMedDate not supplied

A comparison of verapamil and propranolol for the initial treatment of hypertension. Racial differences in response.

We compared verapamil and propranolol hydrochloride for monotherapy of hypertension. Verapamil lowered blood pressure (BP) more effectively than propranolol in black and white patients. Verapamil was equally effective in blacks and whites, whereas propranolol was more effective in whites. Heart rate was reduced by 6.0 beats per minute by verapamil, and by 13.6 beats per minute by propranolol. In blacks, verapamil lowered systolic BP 16.9 vs 8.1 mm Hg for propranolol; verapamil reduced diastolic BP 12.8 vs 8.6 mm Hg for propranolol. In whites, verapamil lowered systolic BP 19.0 vs 12.7 mm Hg for propranolol; verapamil reduced diastolic BP 16.7 vs 12.3 mm Hg for propranolol. Increases in systolic BP were observed in 22% and 3.4% of patients receiving propranolol and verapamil, respectively. The PR interval was increased from 163.5 to 174.9 ms for verapamil vs 160.3 to 164.4 ms for propranolol. Constipation (15%) and headaches (10%) were most frequent complaints for verapamil vs fatigue (18%) and dizziness (7%) for propranolol. Changes in blood biochemistry values were of small magnitude. We conclude that verapamil monotherapy is a safe and effective means of achieving BP control in patients with essential hypertension.

Adult↗
PubMedDate not supplied

Clinicopathological, hematological, and biochemical studies in some outbreaks of nephritis in poultry.

Hematological, biochemical, histoenzymological, and histopathological changes in serum and tissues were studied in chickens during outbreaks of nephritis. Hematological studies revealed normocytic-normochromic anemia characterized by increased total erythrocyte counts, hemoglobin, packed cell volume, and erythrocyte sedimentation rate. Albumin-to-globulin ratio and sodium levels in serum, glucose in blood, and alkaline phosphatase and glucose-6-phosphatase in liver and kidneys were decreased. Glutamate pyruvate transaminase, uric acid, non-protein-nitrogen, and potassium levels in serum were increased. No significant change in the calcium, phosphorus, and total protein levels in serum was observed. These changes were directly related to the severity of the nephritis.

Acid Phosphatase↗