Biomedical subjects
Publications and source records attributed to B Sina.
We document two cases of malignancy occurring at the site of partially removed benign nevi. Because of the difficulty in clinical diagnosis and the uncertainty in its behavior, we propose that any recurring melanocytic nevus expanding beyond the original surgical scar be re-excised and the specimen carefully analyzed to ensure complete removal.
A series of non-circumsporozoite proteins found in pre-erythrocytic parasites are being developed as putative vaccine candidates. It is anticipated that these will be useful in addition to, rather than instead of, the CS (circumsporozoite) vaccines. It is likely that a greater understanding of the basic biology of malaria parasite-host relationships will lead to development of improved malarial vaccines.
A case of nodular basal cell carcinoma occurring within a lentigo maligna is reported. This case illustrates the fact that not all nodules appearing within a lentigo maligna are melanoma.
A case of inflammatory granuloma annulare occurring on the extremities of a young girl is presented. The lesions became erythematous and edematous concurrently with a self-limited gastrointestinal disorder. Many neutrophils were present in the biopsy specimen, which exhibited the changes of granuloma annulare.
A 63-year-old veterinarian acquired sporotrichosis presumably from handling an infected cat. Treatment was successfully completed with ketoconazole, 200 to 400 mg a day for eight weeks. No side effects were noted.
A case of steatocystoma multiplex, which manifested as a foreign body granuloma, is presented. These multiple lesions appear on different body surfaces and were present for more than twenty years before diagnosis.
Disseminated granuloma faciale developed in a 38-year-old man following radiation therapy. A dramatic response to dapsone therapy is noted and the possible role of radiation in the pathophysiology of the disease is presented.
A case of bilateral inflammatory carcinoma of the breast in a man is described. The superficial dermal lymphatics were invaded by the malignancy producing edema and vascular congestion of the upper dermis. This hyperemia produces the clinical appearance of an inflammatory reaction.
Three additional cases of histologically proven eruptive vellus hair cysts are presented. One case had eyelid lesions thus expanding the differential diagnosis for this disease.
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Nineteen cases of keratosis punctata of the palmar creases are presented. This entity, currently regarded as a variant of keratosis punctata of the palms and soles, is seen almost exclusively in blacks. It is benign, mostly asymptomatic, and sometimes familial without any sex predilection. The clinical lesions are pits and keratotic papules confined to the creases of the palms and volar surfaces of the fingers. The soles are rarely affected but a new finding reported here is the involvement of the side of feet in eight of the nineteen cases.
An anergic patient with arrested Hodgkin's disease developed a cutaneous granulomatous panniculitis, an unusual dermatologic manifestation of this tumor. These granulomatous cutaneous lesions were composed primarily of epithelial cells and were free of necrosis. In contrast, focal necrotic areas were present in the granulomas detected two years previously in the original lymph node biopsy examination.
Five new cases of lymphomatoid papulosis are reported. This entity can apparently be divided into at least two subtypes. In one group of patients, papulopustular lesions resembling those of pityriasis lichenoides develop that resolve spontaneously within a few weeks. The lesions contain an epidermotropic dermal infiltration composed predominantly of abnormal lymphocytes. The other group of patients displays larger, more persistent lesions that contain a nonepidermotropic dermal infiltration composed predominantly of histiocytes. Lymphoma eventually develops in about 10% of the patients with lymphomatoid papulosis.
We report two patients who developed multiple keratoacanthomas while receiving photochemotherapy (PUVA). Both patients had received excessive doses of PUVA, which resulted in severe phototoxicity. The role of PUVA in the production of these lesions is discussed.
A 5-month-old boy with hypomelanosis of Ito was studied. Lesions presented as bizarre, hypopigmented whorls and streaks. Histologic studies showed that the hypopigmented areas contained normal melanocytes with decreased content of intracellular melanin. A review of the literature revealed the disease to be a discrete entity of hypopigmentation associated with a high percentage of central nervous system abnormalities, particularly seizure disorders and mental retardation.
A patient who developed rapidly growing, multicentric, cutaneous tumors clinically resembling pyogenic granuloma is reported. In spite of the fact that the local lesions expanded rapidly and contained cytologically "malignant" cells which appeared to invade dermal vessels, the patient had a benign clinical course. The differential diagnosis of "giant pseudomalignant granuloma" is discussed.
Angiosarcoma with initial involvement of the scalp is a rare, malignant neoplasm. We present the case of a 77-year-old woman in whom extensive scarring alopecia developed that was proved histologically to be due to angiosarcoma. She had a good initial response to treatment with electron-beam therapy, but after seven months, extensive nodules and indurated areas on the face beyond the borders of the radiation field developed. Subsequently, massive cervical adenopathy and metastases to the lungs, liver, and spleen developed. Angiosarcoma must be differentiated from other malignant blood vessel tumors and should be considered in the differential diagnosis of scarring alopecia of the scalp in elderly patients.