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Biomedical subjects

B Simon

Publications and source records attributed to B Simon.

At least 379 records · Page 21Linked to original sources
PubMed1980

[Clinical aspects of cytoprotection with prostaglandin analogs].

Various prostaglandins posses antisecretory and cytoprotective actions on gastric mucosa. Cytoprotection by prostaglandins is unrelated to the inhibition of gastric acid secretion and can also be detected in small intestinal mucosa of the rat. Prostaglandins protect gastric mucosa against ulcerogenic compounds such as nonsteriod anti-inflammatory agents (NOSAC) as well as against the necrotizing affect produced by alcohol, 25% sodium chloride, 0.2 N solium hydroxide and 0.6 N hydrochloride acid. Prostaglandins protect in doses that are far too small to inhibit gastric acid secretion. At these doses no side-effects have been noted so far. This cytoprotective effect of prostaglandins might be beneficial in the treatment of a variety of diseases in which gastric mucosal injury in present.

Animals↗
PubMed1979

[Inhibition of pentagastrin-stimulated gastric secretion by ranitidine (author's transl)].

The dose-effect relationship of ranitidine, a recently developed selective histamine H2 receptor antagonist was tested on six healthy subjects after oral administration. Ranitidine gave dose-dependent inhibition of pentagastrin-stimulated acid secretion. Half-maximal inhibition occurred at 75 mg. The antisecretory effect was still demonstrable five hours after oral intake. The drug is thus more powerful and has more lasting antisecretory action, even after oral intake, than cimetidine.

Adult↗
PubMed1979

[Peptic ulcer disease and primary hyperparathyroidism (author's transl)].

The causal relationship of primary hyperparathyroidism and ulcer disease is reviewed. In contrast to earlier ideas careful clinical and clinico-chemical investigations have shown that in patients with manifest primary hyperparathyroidism neither is the incidence of ulcer disease raised nor are deviations from the normal behavior of acid secretion or the serum gastrin level to be observed in comparison with the average population.

Calcium↗
PubMed1979

[Treatment of cimetidine-resistant gastric ulcer with carbenoxolone-sodium (author's transl)].

Case report on a successful treatment of a cimetidine-resistant gastric ulcer with carbenoxolone-Na. Administration of 1.0g cimetidine/d over a period of 8 weeks failed to reduce gastric ulcer size. Subsequent therapy with carbenoxolon-Na caused a complete healing of the gastric ulcer within 4 weeks. This case is discussed with respect to the possible advantages of a combined regimen with drugs of different mechanisms of action.

Aged↗
PubMed1979

Activation of human large bowel adenylate cyclase by methylated prostaglandin E2 analogues.

The effects of methylated analogues of prostaglandin E2 upon the adenylate cyclase system in human colonic mucosa were tested. 16,16-dimethyl-prostaglandin E2 and 15-(S)-methyl-prostaglandin E2 increased the cyclase system in a dose-related manner. Maximal stimulation (about 250%) of enzyme activity occurred at a prostaglandin analogue concentration of 0.1 g/l. Diarrhea seen in patients treated with these orally effective prostaglandin analogues might in part be explained by activation of large bowel adenylate cyclase which is supposed to play a key role in the secretory process in this organ.

Adenylyl Cyclases↗