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Biomedical subjects

B Siegal

Publications and source records attributed to B Siegal.

50 records · Page 3Linked to original sources
PubMed1977

Uterine trauma associated with midtrimester abortion induced by intra-amniotic prostaglandin F2alpha with and without concomitant use of oxytocin.

Five of 80 (6.2%) nulliparous women sustained uterine trauma in association with midtrimester abortion induced by intra-amniotic prostaglandin F2alpha and intravenous oxytocin. All five women suffered cervical lacerations, one extending to the lower uterine segment of the corpus and another associated with myometrial necrosis caused by cornual sacculation and ischemia. No uterine trauma was observed among 95 parous women aborted in the same fashion during this study. The different mechanisms of cervical dilation in the parous woman and the nullipara are offered as an explanation for this difference. Thirty-nine other cases of uterine injury associated with the use of intraamniotic prostaglandin F2alpha from the literature were reviewed, and found to indicate that midtrimester abortion induced by intra-amniotic prostaglandin F2alpha is associated with a significant risk of uterine trauma in the nullipara. The risk seems to increase with the use of oxytocin and with increasing gestational age.

Abortion, Induced↗
PubMed1977

Second trimester abortion: single dose intra-amniotic injection of prostaglandin F2alpha with intravenous oxytocin augmentation.

One hundred-sixty mid-trimester pregnancies were terminated by intra-amniotic injection of Prostaglandin F2alpha with concomitant intravenous oxytocin. Only four of 77 nulliparas and one of 83 multiparas required a second prostaglandin injection. Mean injection-abortion interval was 22.8 hours, and 17.0 hours respectively. This difference between groups was statistically significant. Four nulliparas sustained uterine trauma, a high incidence suggesting that this method may be ill-advised in these women. Because of the predictable short injection-abortion interval in the multipara, this method can be combined conveniently with surgical sterilization.

Abortion, Induced↗
PubMed1976

Acute ureteral obstruction by lymphoceles following cadaver kidney transplantation.

Acute ureteral obstruction caused by perinephric and pelvic lymphoceles developed after the transplantation of a cadaver kidney in a patient who had been on chronic hemodialysis for two years. The patient was readmitted two months after the transplantation and found to have three large cystic masses in the pelvic region, which were successfully drained. Early diagnosis and aggressive surgical treatment of post-transplantation lymphoceles are essential, if the function of the transplanted kidney is to be preserved.

Acute Disease↗
PubMedDate not supplied

The fate of the freeze-preserved xenograft: an experimental study on rabbits, cats, and dogs.

Freeze-preserved allografts have been used successfully in patients for vascular peripheral replacement, dialysis, and chemotherapy. Freezing of veins seems to decrease or abolish antigenicity by decreasing the viable cellular components of the grafts. To confirm its acceptance and consequently, the high patency rates of freeze-preserved vein grafts, we inserted segments of human veins preserved at -80 degrees Centigrade as arterial substitutes into rabbits, cats, and dogs and studied the morphological changes of these xenografts up to 2 years. In all the groups, the patency rate was satisfactory. In rabbits and dogs, the cellular inflammatory reaction around the grafts and suture lines disappeared after a few weeks; the endothelium was reconstructed at 2 months and a poorly differentiated cellular fibro-collagenous wall with prominent hyalin matrix was observed. In cats, however, the histio-lymphocytic infiltrate persisted in functioning grafts up to 2 years associated with adjacent prominent vascular and nerve proliferation. It is suggested that this inflammatory reaction has no deleterious effect on the graft; on the contrary, it promotes its neovascularisation and innervation. The cat proved to be a good animal model for vascular surgical experiments. Our study proved the poor antigenicity of freeze-preserved venous xenograft. It could, in the future, be used for human arterial substitutes.

Animals↗
PubMedDate not supplied

Freeze-preserved vein grafts and atherosclerosis. An experimental study.

Histopathological changes of three types of vein grafts were studied. Freeze-preserved, fresh human grafts and autografts were inserted as patches in the aorta of rabbits on regular and variable cholesterol diets. In all grafts the endothelium and adventitia were reconstituted after a few months. In the wall, smooth muscle and elastic tissue were markedly diminished and poorly oriented with accompanied collagenisation. Cholesterol diet led to progressive fat and/or calcium deposition with subintimal proliferation in the autografts and fresh xenografts. In contrast this was seen to a much lesser degree and later in freeze preserved xenografts, even on higher cholesterol diets. Deep freezing considerably reduces the cellularity of the graft and its metabolic ability to accumulate lipids. Freeze-preserved veins seem to be a suitable graft for vascular reconstructions in severely atherosclerotic patients and compare favorably with vein autografts.

Animals↗
PubMedDate not supplied

Collateral flush technique.

The collateral flush technique consists of preserving a collateral branch of the vein when performing AV fistulas. This allows the surgeon to check the immediate patency of both the anastomotic line and the limbs of the arteriovenous fistula; perform thrombectomy easily and rapidly in the event of early thrombosis (up to seven days following surgery) without disturbing the anastomotic line; and perform on-the-table arteriograms using minimal amounts of contrast material and without direct puncture of the artery. This technique has been used with good results in 300 patients and its routine use is recommended.

Adolescent↗
PubMedDate not supplied

Access operation for chemotherapy and dialysis using freeze-preserved vein allografts.

Freeze-preserved vein allografts were used to perform 25 angioaccess operations, 17 for dialysis and 8 for chemotherapy purposes. The freeze preserved vein allograft has proved to be relatively cheap, highly dependable graft material, with a high patency rate and a low incidence of complications. Anticoagulation, while unnecessary in the dialysis patients, is recommended in the oncological group.

Arteriovenous Shunt, Surgical↗