Biomedical subjects
B Sheff
Publications and source records attributed to B Sheff.
Minimizing the threat of C. difficile.
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Microbe of the month. Streptococcus pneumoniae.
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Neisseria meningitidis
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Oral Candida albicans.
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Reining in a runaway infection.
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Escherichia coli (E. coli) O157.H7.
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VRE & MRSA. Putting bad bugs out of business.
Are you unwittingly contributing to the spread of these dangerous antibiotic-resistant organisms? Learn to protect your patients--and yourself--from out-of-control infections.
VRE & MRSA--putting bad bugs out of business.
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Transient high titers of HIV-1 in plasma and progression of disease.
Periodic quantitative HIV-1 plasma cultures were performed on 28 seropositive individuals who had CD4 cells < or = 300/mm3 and who were enrolled in three clinical trials testing the efficacy of didanosine versus zidovudine monotherapy. Most plasma cultures were negative or of low titer (1-100 tissue culture infective dose/ml of plasma), but there were 14 instances of high-titered plasma viremia (> or = 1,000 tissue culture infective dose/ml of plasma) seen in 11 individuals. These peaks in plasma culture titers were significantly associated either with rapidly decreasing CD4 cell numbers or with CD4 cells already < 50/mm3. In addition, patients who experienced these episodes of high-titered plasma viremia were more apt to have clinical complaints of fever, rash, flu-like illness, and/or opportunistic infection and also the syncytium-inducing HIV-1 phenotype and progression of disease.