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Biomedical subjects

B Sever

Publications and source records attributed to B Sever.

6 recordsLinked to original sources
PubMed2004

Antioxidant properties of Ballota species growing in Turkey.

In the present study, the antioxidant properties of ethanol extracts of 16 Ballota species belonging to the Lamiaceae family and growing in Turkey on superoxide anion formation and lipid peroxidation were investigated. All extracts inhibited superoxide anion formation but to different extents. The extracts of Ballota antalyense, Ballota macrodonta, Ballota glandulosissima, Ballota larendana, Ballota pseudodictamnus, Ballota nigra subsp. anatolica, Ballota saxatilis subsp. saxatilis, Ballota rotundifolia, and Ballota saxatilis subsp. brachyodonta exhibited remarkable anti-superoxide anion formation with IC(50) values from 0.50 to 0.87 mg/ml. The extracts of Ballota antalyense, Ballota macrodonta and Ballota glandulosissima have the lowest IC(50) values (0.50, 0.51 and 0.51 mg/ml, respectively) which were rather close to the well-known superoxide anion scavenger alpha-tocopherol (IC(50): 0.22 mg/ml). The extracts of Ballota inaequidens, Ballota glandulosissima, Ballota saxatilis subsp. saxatilis, Ballota macrodonta and Ballota antalyense inhibited lipid peroxidation with IC(50) values from 12 to 20 mg/ml. The extracts of Ballota inaequidens (IC(50): 12 mg/ml) and Ballota glandulosissima (IC(50): 15 mg/ml) exhibited the strongest inhibitory effects on lipid peroxidation compared with alpha-tocopherol (IC(50): 3 mg/ml). The results show that Ballota glandulosissima is the best antioxidant source among these 16 Ballota species.

Animals↗
PubMed2000

Psychosocial characteristics of patients with bronchial asthma and coronary disease: similarities and differences.

The authors compare two groups of subjects: patients with bronchial asthma and those with coronary disease, with regard to some social characteristics, abilities and perception of factors which they conceive are important in the etiology of their disease. Data were obtained by means of a questionnaire based on a known calibrated scale. A group of 100 patients with bronchial asthma and a group of 102 patients with coronary disease were examined. The significance of the difference was tested by chi 2, t-test, Wilcoxon's test and multivariate discriminative analysis. The results showed statistically significant differences between the patients with bronchial asthma and those with coronary disease in some social and psychological characteristics and also with regard to perception of potential etiological factors of their disease. However, no difference was found in life style and habits between the coronary and asthmatic patients.

Adult↗
PubMed1995

Investigation of the effects of moclobemide in chronic ethanol feeding rats.

Effects of chronic moclobemide administration on ethanol consumption, blood ethanol level, motor coordination and seizures induced by an audiogenic stimulus during ethanol withdrawal syndrome have been investigated in chronically ethanol intoxicated rats. Adult male Wistar rats (211-289 g) were used. Ethanol (7.2% v/v) was given to rats by a special liquid diet for 15 days. Moclobemide (10, 30 and 45 mg kg-1) or saline was injected to ethanol-feeding rats subcutaneously through 15 days. Daily ethanol intake and body weight gain of the rats were recorded. Blood ethanol levels were measured in rats given saline or chronic moclobemide (30 mg kg-1) just before and 6 h after ethanol withdrawal. At the sixth hour of the ethanol withdrawal, the incidence, intensity and latency of the seizures induced by an audiogenic stimulus were recorded in saline and acute (30 mg kg-1) or chronic (10, 30 and 45 mg kg-1) moclobemide-administered rats. Accelerod performances of the chronic moclobemide (45 mg kg-1) or saline injected rats were also evaluated. The mean ethanol intake of the rats ranged from 10.06 to 15.63 g kg-1 day-1 during the study. Chronic moclobemide treatment did not occur any significant effect on daily ethanol consumption, ethanol clearance and accelerod performances of the rats. No significant changes on the incidence, intensity and the latency of the audiogenic seizures were also observed. Our results suggest that there has been no adverse interaction between ethanol and moclobemide.

Alcohol Drinking↗
PubMedDate not supplied

[Cytomorphologic changes in bronchial epithelial cells in a patient exposed to an aerosol of the organophosphorus insecticide, Ekalux 25 (quinalphos), 0,0-diethyl-0-quinoxaline-2-phosphorothioate].

In this paper, the authors present cytomorphological changes of the bronchial epithelial cells in the patient who inhaled aerosol organophosphate insecticide "Ekalux 25" 0,0-diethyl-0-quinoxaline-2-il-phosphorothioate, while spraying crops, i.e. Colorado beetle. Our cytomorphologic examination of the sputum (obtained on the 13th and 15th day after the patient's exposure to the insecticide) revealed neutrophil granulocytes, degenerate changed macrophages, degenerate changed bronchial epithelial cells, squamous metaplasia with a poor number of lymphocytes and erythrocytes. Beside this, we also found atypical hypertropic cells of the bronchial epithelium (occurring in single forms or in groups) most of which appeared to be without cilia. Cytoplasm of those cells occurred to be not sharply bordered but poor and had a grey blue colour. Chromatin pattern of the nuclei was more coarse or "wiped", while nucleoli, as rule, appeared to be not discernible. There also occurred some nuclei in mitosis. The number of nuclei in those cells varies from one to several. Sputum specimens obtained later for cytologic analysis as well as bronchoscopic specimens, obtained on the 17th day after the patient's admission to the hospital, did not show any similar cytomorphologic changes. The authors of this paper think that it would be interesting to examine and follow-up the cytomorphologic specimens (bronchial secret, catheter bronchial aspirate smears, brushing and histopathologically) as early as the first days (if it is possible) of a patient's exposure to the organophosphate compounds.

Adult↗