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Biomedical subjects

B Schulz

Publications and source records attributed to B Schulz.

At least 163 records · Page 9Linked to original sources
PubMed1977

[Obesity as a metabolic risk factor].

On the basis of the results of clinico-experimental examinations and of animal experiments the importance of obesity as metabolic factor of risk is confirmed and hereby the diabetes mellitus as well as cardiovascular effects are particularly taken into consideration. Conclusions are made relevant to practice and it is particularly referred to the central position of the B-cells for the pathogenesis of diabetes as well as to prophylactic and early therapeutic measures.

Adult↗
PubMed1976

[Carbohydrate tolerance and behavior of insulin in the glucose infusion test in persons with normal weight with prediabetic suspicion].

In altogether 289 persons with normal weight with suspicion of the existence of a prestage of diabetes the 2 hour's glucose infusion test was carried out. In these cases 61% of the test persons showed a normal, 8% a critical, 26% a pathological and 5% a manifest diabetic metabolic condition. A reduction of the initial and late phase of the insulin secretion provable with deterioration of the carbohydrate tolerance must be regarded as cause of metabolic disturbances. The lack of a significant relation between diabetic heredofamiliality and carbohydrate tolerance indirectly refers to the importance of the environmental factors which on the basis of a genetic defect have a decisive influence of the morbidity caused by diabetes. The reduction of the initial phase which is provable already in potential diabetes, particularly clearly it is to be demonstrated in pathological and manifest diabetic metabolic situation, may be regarded as an early symptom of diabetes. Carbohydrate tolerance and preparation of insulin were reduced in decenniums of older age.

Adult↗
PubMed1976

[Relations between portal and peripheral venous insulin, proinsulin and glucagon concentrations after oral glucose in man].

During cholecystectomy a catheter was inserted into the V. porta via V. umbilicalis. 7 or 8 days later an oral glucose tolerance test was performed (100 g). Blood glucose, insulin (IRI), proinsulin-like material (PLM), and pancreatic glucagon (IRG) concentrations were determined in portal as well as in peripheral venous blood. 5 out of 6 patients showed a disturbed carbohydrate tolerance in comparison to 53 healthy subjects. The IRI increased promptly after the oral glucose load. The portal IRI-concentrations are significantly enhanced in comparison to the peripheral levels, but between both a positive correlation exists (r = 0.9447; p less than 0.01). PLM was slightly increased in the first 10 minutes. The basal IRG levels were not enhanced. Significant differences between the portal and peripheral IRG concentrations could not be observed. The correlation coefficient was 0.8902. Thus, the peripheral venous concentrations of IRI, PLM and IRG can be used as a diagnostic tool of pancreatic hormone secretion in man.

Administration, Oral↗
PubMed1975

[Diagnosis of the early stages of diabetes and prevention of diabetes manifestations].

According to our experiences the value of the GIT in the diagnostics of the pre-stages of diabetes on account of the recognizability of the two phases of secretion of insulin and the good reproducibility is above the value of the oGTT and iGTT. In consequence of the large methodical expenditure it is left to the highly specialized stationary diagnostics. The development of the carbohydrate intolerance is concomitant with a significant reduction of the glucose-induced insulin secretion in the early phase. In contrast to this, in about 70 per cent the second phase of secretion corresponds to the normal when the pathological carbohydrate tolerance appears and is significantly reduced to 60 per cent only at the time of the manifestation of diabetes. The reduction of weight as well as buformin are suitable therapeutics of the manifestation prophylaxis. In these cases in the adipose asymptomatic diabetes should primarily always be striven for a normalisation of the body-weight, whereas for test persons with normal weight the indication for the buformin-therapy is given.

Carbohydrates↗
PubMed1975

[Correlations between human portal and peripheral venous insulin and proinsulin concentrations under glucose infusion].

In 8 female patients carbohydrate tolerance was proved by means of glucose infusion test 3 days after cholecystectomy. Parameters analyzed in portal and peripheral vein blood are compared with that of 47 healthy persons. All patients demonstrate a pathological carbohydrate tolerance after cholecystectomy, further characterized by an increased lipolysis, a paradoxical rise of HGH, a diminished insulin secretion during the early and increased IRI output in the second phase. There is a significant positive correlation between portal and peripheral vein IRI concentration despite the rising portalperipheral venous IRI difference with raised portal venous IRI concentration. Corresponding differences for proinsulin concentrations can be established in the early phase only. Relations existing between blood glucose and IRI are shown by multiple regression analysis. They suggest that the altitude of IRI concentration is determined by previous blood glucose concentration.

Adult↗
PubMed1975

[Results of long-term biguanide therapy as a preventive measure in protodiabetes].

55 patients with pathological glucose tolerance received a long term treatment with buformin (200 mg daily). In 43 of the protodiabetics the duration of treatment was one year, in 29 of them two years and in 11 three years. The age of the patients was 38 years and the mean relative body weight was 118 per cent. The effect of buformin on glucose tolerance and insulin secretion was tested with the glucose infusion test before and after the periods of treatment. After one year we found in 58 per cent, after two years in 69 per cent and after three years in 64 per cent of the protodiabetics an improvement of glucose tolerance. In these groups the results showed a rise of the IRI in the low responder and a decrease of the IRI in the high responder. The good effects on glucose tolerance were not demonstrable in the compared groups with long-term treatment of diet only.

Adolescent↗
PubMed1975

Effect of glucose infusion on venous blood levels of immunoreactive proinsulin activity, insulin activity and fat parameters in healthy and protodiabetic subjects.

Concentrations of immunoreactive insulin activity (IRI) and proinsulin activity (IRP), blood glucose, free fatty acids (FFA), glycerol, cholesterol, triglycerides were analyzed in 140 subjects suspect of protodiabetes and 50 healthy persons before, during and after a glucose infusion test (GIT). The protodiabetic subjects were classified into normweight, overweight, obese, hyperlipemic groups with diet or with Regadrin therapy and each of them subdivided into such with normal and such with pathological carbohydrate tolerance. Norm- and overweight subjects with asymptomatic diabetes were characterized by a significant reduction of insulin secretion during both phases. Obese patients with or without hyperlipoproteinemia demonstrated an increased IRI reaction during the late phase of secretion. Carbohydrate intolerance was associated with an enhancement of basal triglyceride levels and a reduced depression of glycerol and FFA during the GIT. There were no differences in fasting or reactive IRP concentrations between healthy and protodiabetic subjects with normal carbohydrate tolerance. In asymptomatic diabetes the IRP levels were increased during the late secretion phase, but the percentage of IRP in total IRI was normal or--in existing high response--significantly reduced in comparison to norm response. The results do not support an enhanced IRP secretion as the cause of carbohydrate intolerance.

Adult↗