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Biomedical subjects

B Schnitzer

Publications and source records attributed to B Schnitzer.

At least 109 records · Page 6Linked to original sources

Pitting function of the spleen in malaria: ultrastructural observations.

Ultrastructural studies of spleens from monkeys infected with Plasmodium knowlesi suggest that the spleen removes or "pits" malaria parasites from red cells. This function may explain the presence of nonparasitized spherocytic erythrocytes in the peripheral blood and may in part account for the discrepancy between the excessive hemolysis and the number of parasitized erythrocytes in animals with experimentally induced malaria.

Animals↗

Erythrocytes: pits and vacuoles as seen with transmission and scanning electron microscopy.

Vacuoles containing inclusions were observed by transmission electron microscopy in erythrocytes of a splenectomized patient with hemoglobin Ann Arbor. The membranes of these vacuoles became fused with the surface membrane of the red cell, thus opening the vacuoles and exposing their contents to the outside. These vacuoles when they have become thus attached to the cell membrane of the erythrocyte are responsible for the pits observed with scanning electron microscopy.

Cytoplasm↗