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Biomedical subjects

B Sanyal

Publications and source records attributed to B Sanyal.

At least 37 records · Page 2Linked to original sources
PubMed1981

Ewing's sarcoma: A combined approach in the management.

Twenty-seven histologically confirmed cases of localised Ewing's sarcoma were treated by two different regimes. Radiotherapy alone was used in 13 cases and a combination of chemotherapy and radiotherapy in 14. Single agent chemotherapy (cyclophosphamide) was given sequentially in nine patients and cyclophosphamide and actinomycin-D in five. There is a significant difference in the response to these different regimes. Only 69.2% of patients treated by radiotherapy alone were disease-free, for a median period of 10.4 months and metastases were noticed in 53.8% of cases. The disease-free survival in patients treated by combination therapy (radiotherapy and chemotherapy) was 18.4 months and metastases were seen in only 42.9%. However, no metastases were seen in patients who received cyclophosphamide and actinomycin-D, during a period of 14 months and only one patient showed residual disease. It is concluded that the addition of cyclophosphamide alone is not adequate in the management of Ewing's sarcoma. Actinomycin-D in addition to cyclophosphamide has improved the disease-free survival period significantly. The optimum dose of radiotherapy and its combination with other chemotherapeutic agents needs further trials to find the best and most suitable schedule.

Adolescent↗
PubMed1980

Extramedullary plasmacytoma: simulating a soft tissue sarcoma of the chest wall.

Extramedullary plasmacytoma occurs infrequently as compared to osseous myoloma. A single case of extramedullary plasmacytoma was seen during the last 10 years whose initial presentation was that of a soft tissue sarcoma of the chest wall. Clinical data along with relevent investigation and treatment results are discussed with a review of the literature.

Biopsy↗
PubMed1980

Symptomatic vertebral haemangiomas.

Twelve cases of symptomatic vertebral haemangioma are reported in respect of their clinical presentation and radiological findings. One patient was only 10 years old, the youngest patient ever reported. Less commonly known findings of associated paravertebral mass and the displacement of the thoracic paraspinal line are discussed.

Adult↗
PubMed1979

Radiation myelopathy.

Five cases of radiation myelopathy were found in a total of 10,000 cases given radiotherapy from 1968 to 1977. The clinical presentation and treatment details including the total dose, treatment volume, number of fractionations, overall time, and the RET value at the spinal cord were calculated and compared with other reports on this subject. The total number of fractionations ranged from 20 to 26 with an overall time of 32 days to 37 days. The dose received by four patients ranged from 1030 to 1900 RET, a little higher than the tolerance level of the spinal cord as compared to reported values. Two patients in this series had high blood pressure. The incidence of radiation myelopathy, already acceptably low, could possibly be reduced further by meticulous planning of radiation.

Carcinoma, Squamous Cell↗
PubMed1978

Nonsporing, anaerobic, gram-positive rods in saliva and the gingival crevice of humans.

Quantitative and qualitative examination of anaerobically isolated flora of the gingival crevice and saliva was carried out. It was found that half the organisms were anaerobes and that there were twice as many gram-positive organisms as there were gram-negative ones. Rods were predominant in the gingival crevice (60.5%) and cocci in saliva (69.1%). Of the total organisms, nonsporing, gram-positive anaerobic rods accounted for 24% in the gingival crevice and 9.7% in saliva. These organisms were characterized on the basis of the type of fatty acids produced from glucose and various biochemical reactions. They belonged to the following genera: Actinomyces, Propionibacterium, Arachnia, Lactobacillus, Eubacterium, and Bifidobacterium. Bifidobacteria were present only in saliva. Although members of the other genera were present both in the gingival crevice and saliva, there were considerable differences in the proportion of any particular organism (in relation to the total anaerobic viable count) between the two sites. The result of this study also indicates a greater than previously appreciated level of Propionibacterium and Arachnia in the human mouth.

Adolescent↗