Pediatric priorities in India in the 1980's.
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Biomedical subjects
Publications and source records attributed to B Sankaran.
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We investigated the pattern of genetic susceptibility to rheumatic diseases in Indians by means of HLA analysis. HLA B27 was present in more than 90% of cases included under the broad category or seronegative spondarthritides. In this respect our data resembled results reported for Caucasian populations. In our population, however, the phenotypic frequency of HLA B27 was low as reported from Japan.
A clinico-radiological study conducted on 124 patients including 89 cases of spinal canal stenosis and 143 normal (control) individuals is presented and the various causes of stenosis of the spinal canal are reviewed. Evaluation of canal to body ratio using plain radiographs of lumbo-sacral spine based on the Jones and Thomson technique and myelography were found very useful in diagnosing spinal canal pathology preoperatively. Spinal stenosis is more common in males, predominantly in the fourth decade. Extensive decompression laminectomy in appropriately selected cases yielded satisfactory results, any associated prolapse intervertebral disc requiring excision of the herniated disc in addition to laminectomy.
A series of 145 patients (77 males and 68 females) with fracture of the neck of the femur treated by primary replacement arthroplasty (prosthesis) is presented. The indications, complications and results of operation are discussed. Prosthetic replacement has yielded satisfactory results in 91.7 per cent of cases and is a particularly suitable procedure for Indians.