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Biomedical subjects

B S Setty

Publications and source records attributed to B S Setty.

At least 73 records · Page 4Linked to original sources
PubMed1977

Influence of sex steroids on the secretory function of the epididymis in castrated rats.

Secretory response of the epididymis to exogenously administered testosterone, estrogen and progesterone was investigated using the levels of sialic acid and glycerylphosphorylcholine as indices. Testosterone was found to be most potent in stimulating the (GPC) secretory function of the organ. An enigmatic finding of the present study was that while estrogen showed the ability to stimulate both sialic acid and GPC levels, progesterone exerted its influence only on sialic acid. Studies on the accessory genital organs (weight of seminal vesicles and ventral prostate and fructose level of coagulating gland) also revealed a stimulatory effect of the steroids.

Animals↗
PubMed1976

Studies on the physiology and biochemistry of mammalian epididymis: effect of flutamide, a nonsteroidal antiandrogen, on the epididymis of the rat.

The effect of flutamide (Sch 13521; 4'-nitro-3'-trifluoromethylisobutyranilide), a nonsteroidal antiandrogen, on male rat genital organs was studied. Administered at a dose of 25 mg/kg body weight daily for 30 days, flutamide caused a significant increase in the weight of the testis but had no effect on spermatogenesis and Leydig cell morphology. The secretory activity of the epididymis, as evidenced by the level of glycerylphosphoryl-choline and sialic acid, either remained unaffected or was stimulated. There was a significant decrease in seminal vesicle and ventral prostate weight and in the fructose content of the coagulating gland. The anti-androgen at the dose used did not affect the fertility of the rats. The significance of these findings is viewed in relation to the hypothesis of a differential threshold requirement of androgen for the epididymis and the accessory sex glands. The potentiality of antiandrogens as extragonadal antifertility agents in the male is discussed.

Anilides↗
PubMed1976

Antifertility agents. 12. Structure-activity relationship of 3,4-diphenylchromenes and -chromans.

Synthesis and antiimplantation activity of variously substituted 2,2-dialkyl-3,4-diphenylchromenes and 3,4-cis- and trans-chromans derived from them are described. Pregnancy-inhibiting activity in rats was exhibited by a number of these compounds, which was particularly marked in the case of 3,4-trans-3-phenyl-4-p-(beta-pyrrolidinoethoxy)-phenyl-7-methoxychroman (32), the corresponding 2,2-dimethyl analog 34, and 3-phenyl-4-p-(beta-pyrrolidinoethoxy)phenyl-7-methoxychromene (26). The structure-activity relationship of these compounds is discussed.

Animals↗
PubMed1976

Epididymal response to exogenous testosterone in rats sterilized neonatally by estrogen.

Male rats treated with estradiol dipropionate (250 mug) by subcutaneous injection on Day 5 of postnatal life failed to show maturation changes in the testis and epididymis at puberty. Histological examination at 60 days revealed inhibition of spermatogenesis at primary spermatocyte stage and atrophic Leydig cells. Epididymis presented infantile features and there was a marked reduction in the secretory activity as revealed by lowered concentration of sialic acid and glycerylphosphorylcholine. Testosterone therapy (1 mg/day) for a period 45 days prior to autopsy at 60 days failed to induce completion of spermatogenesis but restored the structural and functional integrity of the epididymis.

Animals↗