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Biomedical subjects

B S Rathore

Publications and source records attributed to B S Rathore.

7 recordsLinked to original sources
PubMed1981

Clinical trial with CIBA 1906 in lepromatous leprosy.

Drug trial with CIBA 1906 was conducted in 50 cases of lepromatous leprosy who were intolerant to dapsone therapy. Drug was tolerated well and lepra reactions were infrequent and mild. Clinical improvement was seen in 72% cases whereas no appreciable change was detected in 28% cases. An average reduction of 0.4 in BI was detected in 62% cases, while remaining cases did not show any reduction in BI. No significant side effects were encountered during the study. Antibacterial activity of CIBA 1906 was not found superior to dapsone.

Adult↗
PubMed1979

Activity and effective serum level of repository sulphones (DADDS) in lepromatous leprosy.

35 cases of lepromatous leprosy were studied to evaluate the effective blood level and long depot action of acedapsone (DADDS). It was revealed that serum level of this drug is maintained well above the minimum inhibitory concentration upto 60 days following single intramuscular injection. No significant untoward effects of the drug were encountered except one case of Erythema Nodosum Leprosum and six patients with mild reactional symptoms in the form of fever and arthralgia.

Acedapsone↗
PubMedDate not supplied

The protective action of essential oils of onion and garlic in cholesterol-fed rabbits.

The effects of the essential oils of onion and garlic have been investigated in cholesterol-fed rabbits and have been compared with the effects of clofibrate. The marked rise in serum cholesterol and blood coagulability that followed 3 months of cholesterol feeding (0.2 g/kg/day) was significantly reduced by the essential oils of both onion and garlic. Fibrinolytic activity was actually increased even above the normal control levels. The essential oils of onion and garlic (equivalent to 1 g/kg/day of raw bulbs) proved more effective than clofibrate in the usual clinical dose of 33 mg/kg/day. Garlic was even more effective than onion. Cholesterol feeding increased the average lipid content of aorta from 5.95 to 13.75 mg/100 mg dry weight. With addition of clofibrate, onion or garlic the values were 7.79, 6.23 and 5.28 mg/100 ml, respectively. Thus it can be seen that the essential oils effectively prevent lipid acculation in the rabbit oarta.

Animals↗
PubMedDate not supplied

Value of pilocarpine test in early diagnosis of leprosy.

Modified Pilocarpine Test was carried out in 48 patients under investigation for Leprosy. 37 cases showed deficient sweating of varying degree. Many of these patients did not reveal confirmatory histopathological changes and were bacteriologically negative. In the absence of other causes of neuropathy this finding of deficient sweating by modified pilocarpine test, was significant. Same test was carried out in 8 confirmed cases of Tuberculoid leprosy. All cases showed positive results.

Humans↗