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Biomedical subjects

B S Cooper

Publications and source records attributed to B S Cooper.

At least 55 records · Page 3Linked to original sources
PubMed1982

Effect of acetylcholine, prostaglandin F2 alpha and estradiol on number of sperm in the reproductive tract of inseminated rabbits.

Acetylcholine, injected im into does immediately after natural mating, significantly increased the number of sperm recovered 1 h later from the vagina and cervices but not from the oviducts. Acetylcholine caused immediate increases in the frequency and amplitude of uterine contractions as measured by strain-gauge force transducers attached to the serosa and recorded by physiograph; contraction patterns returned to the preinjection pattern within 30 min. Administration of prostaglandin F2 alpha (.75 mg) at the time of insemination increased sperm numbers significantly at 2.5 h in the oviducts, uterus and cervices; .15 or 3.75 mg caused relatively little increase in sperm numbers. Prostaglandin F2 alpha increased the number and strength of uterine contractions for more than 30 min. Estradiol injected 1 h before artificial insemination increased the number of sperm recovered from the oviducts, uterus, cervices and vagina at 2.5 h after insemination. Estradiol caused little if any detectable increase in the frequency or strength of uterine contractions during the period of increased retention and transport of sperm. When does were inseminated with low numbers of sperm (86,000), prostaglandin F2 alpha and phenylephrine, used for comparison, each increased the ovum fertilization rate (22% for control does; 76 and 73%, respectively, for prostaglandin F2 alpha- or phenylephrine-treated does).

Acetylcholine↗
PubMed1978

Effect of liver microsome enzyme-inducing drugs on blood serum pentobarbital clearance and sleep time in sheep and rabbits.

Sheep were administered phenobarbital, diphenylhydantoin, chlorcyclizine, or phenylbutazone over 27 days. Rabbits were administered phenobarbital, diphenylhydantoin, or chlorcyclizine for 15 days. After the last treatment, pentobarbital was administered intravenously, and measurements were made of sleep time and blood serum pentobarbital concentrations over a 2-hour period. Treatment of ewes with phenobarbital or phenylbutazone increased the rate of pentobarbital clearance from the circulation and shortened sleep time; treatment with diphenylhydantoin or chlorcyclizine decreased the rates of pentobarbital clearance from blood and increased sleep time. Treatment of rabbits with phenobarbital or diphenylhydantoin accelerated pentobarbital clearance from blood and shortened sleep time; chlorcyclizine had no effect on blood pentobarbital concentrations or sleep time. The results suggest that accelerated or delayed clearance of pentobarbital from the circulation was largely responsible for shortened or prolonged sleep times. Other factors may have been involved to some extent in determining sleep time, because ewes with shortened sleep time tended to awake with lower circulating concentrations of pentobarbital than did control ewes, and those with prolonged sleep time tended to awake with higher pentobarbital values.

Animals↗
PubMed1976

The economic cost of illness revisited.

In and out of government, determining the cost of illness is a major concern. The allocation of health care resources and the evaluation of current research and program efforts depend in large measure on such information. This article updates the 1963 benchmark study of the cost of illness. For the 16 major diagnostic categories of illnesses, the cost is presented in terms of the direct costs for prevention,detection, and treatment; the morbidity losses due to disability; and the mortality losses resulting from premature death. The method of calculating the cost of any illness is described, and data necessary for the calculation are provided. In 1972, the estimated total cost of illness was $188 billion: $75 billion for direct costs, $42 billion for morbidity, and $71 billion for mortality. Diseases of the circulatory system were the most costly, representing about one-fifth of all costs of illness.

Activities of Daily Living↗