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Biomedical subjects

B S Chaubey

Publications and source records attributed to B S Chaubey.

At least 19 recordsLinked to original sources
PubMed1995

Efficacy of zinc therapy in prevention of crisis in sickle cell anemia: a double blind, randomized controlled clinical trial.

145 patients were recruited in the trial while 130 completed it. Patients were randomized to receive zinc sulphate capsules. 220 mgm three times a day or identical placebo. Major outcome variable was 'Sickle cell crisis'. After a follow up of 1.5 years, the mean number of episodes of crisis was 2.46 +/- 1.04 in the intervention group and 5.29 +/- 2.58 in the control group (p < 0.025; 95% CI for difference between groups: 1.98, 3.42). Mean duration of hospital stay was 4.3 +/- 2.2 days in the intervention group and 3.9 +/- 1.6 days in the control group. The difference was not significant (p > 0.05). There was a significant reduction of the mean number of infective episodes and associated morbidity in patients with sickle cell anaemia.

Administration, Oral↗
PubMed1990

Fluorosis in Maharashtra.

In all 241 school going children from the adjacent villages in Rajura taluka of Chandrapur district in Maharashtra were screened for dental fluorosis. Additionally 38 adult persons were also screened. The population in these villages appears to be at risk for fluorosis. Water fluoride level of 20 ppm from the village Dhoptala is the highest reported fluoride concentration in drinking water sources in the state. The entire area needs further investigations.

Adult↗
PubMed1983

Renal abnormality in leprosy.

Adequate kidney biopsy was studied in 54 cases of leprosy, of which 45 were of lepromatous leprosy, 4 of tuberculoid type and 5 belonged to borderline type of leprosy. Membranous glomerulonephritis (31.5%) was the commonest type of glomerular lesion followed by mesangioproliferative glomerulonephritis (11.1). It is concluded that renal lesions can occur in any type of leprosy. Reaction of renal tissues to M. leprae could be due to various local immunologic or physiological factors.

Adult↗
PubMed1981

A study of cell mediated immunity in leprosy.

This paper presents a review of 123 cases of leprosy of different clinical types as regards to their status of cellular immunity. These 123 cases included 41 fresh cases, 18 cases of reaction and 64 cases of leprosy taking antileprosy treatment. Out of 41 untreated cases only 11 turned up for follow up and their lymphoblastic transformation was repeated 4 to 6 months after initiating the treatment. It was observed that cell mediated immunity as expressed in terms of percentage of blast cells is definitely depressed in leprosy, most in LL and least in TT. There is a definite increase in the percentage of blast cells after taking antileprosy treatment. The rise in percentage of blast cells and hence cellular immunity is relatively more in patients treated with Lamprene as compared to those treated with DDS. Reactions also have impact over immunity in leprosy. Thus, most of the patients with ENL show higher values for blast percentage as compared to those with lepra reaction. It appears that serial lymphocyte cultures if done in all cases of leprosy undergoing treatment will help in assessment of individual progress.

Adolescent↗