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B Rutkowski

Publications and source records attributed to B Rutkowski.

At least 91 records · Page 5Linked to original sources
PubMed1995

[Does erythropoietin treatment influence the lipid status of patients on maintenance hemodialysis?].

UNLABELLED: Plasma lipid disturbances are common among patients on maintenance haemodialysis and it seems to be important to evalate lipid status on r-Epo since this treatment of anemia is becoming substantial and so often used in that population. It appears more valuable because there are controversial data in the literature concerning this problem. The aim of the present study was to measure changes in serum lipid concentration in two comparable groups: I--11 patients (7f, 4m) aged 47 +/- 8 years receiving r-Epo s.c. during at least 6 months before HD and 2 years of HD with initial dose 3 x 50 u/kg b.w. and II--18 patients (7f, 11m) aged 45 +/- 8 years without r-Epo in that period of time. Following parameters were estimated every two months: total cholesterol (CH-C), HDL cholesterol (HDL-CH), LDL cholesterol (LDL-CH), triglycerides (TG), apolipoprotein B (Apo B). CONCLUSIONS: 1. Subcutaneous therapy with r-Epo is an effective method of treatment of anemia in dialysis patients. 2. Long-term r-Epo treatment does not permanently influence the blood lipid profile in hemodialysed patients.

Adult↗
PubMed1994

[Some clinical aspects of erythropoietin action used at doses not affecting erythropoiesis in hemodialysed patients].

Erythropoietin has become a crucial point in treatment of anaemia in patients with chronic renal failure. Recently a very important point of concern are the non hematological aspects of its action. The aim of presented study was to evaluate the biochemical and clinical effects of using erythropoietin at doses not influence hemopoiesis. 10 hemodialysis patients with stable hemoglobin and hematocrit levels, were given erythropoietin at dose of 7-10U/kg.b.w./d--the dose not affecting erythropoiesis. Erythropoietin was administered subcutaneously, 3 times a week, for 12 weeks. In this way, we tried to evaluate the direct effects of erythropoietin action, not associated with a correction of anemia. After the therapy a statistically significant decrease was seen of total cholesterol (p < 0.01), LDL-cholesterol (p < 0.01) in serum of these patients. The concentration of triglycerides, HDL-cholesterol, glucose and insulin changed in a variable mode. We did not find any significant changes in hemoglobin and hematocrit levels, but despite of that we observed a significant decrease of lactate (p < 0.01). It seems that the global result of all mentioned changes was a great improvement in the "quality of life" of this group of patients.

Adult↗
PubMed1994

[Andrzej Manitius].

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History, 20th Century↗
PubMed1994

[Effect of human recombinant erythropoietin (r-EPO) on behavior of iron status parameters in patients with chronic renal failure treated with dialysis].

For proper erythropoietic response to r-Epo iron, folic acid and B12 vitamin are needed. Iron deficiency is the most common in uremic patients treated with r-Epo. So the aim of presented study was to measure hematological and iron status changes. Studies were carried out in 23 anemic, uremic, hemodialysis patients. They were divided into two groups, the first HDa--5 people (3W, 2M) aged 23-49 (mean 34 +/- 12) years and the second HDb 18 patients (11W, 7M) aged 21-56 (mean 38 +/- 12) years. Mean hemoglobin (HGB) before r-Epo was 6.9 +/- 1.0 g/dl in HDa, and 6.7 +/- 1.1 g/dl in HDb. r-Epo in HDa group was given during 12 weeks i.v. and afterwards s.c. for other 4 weeks with initial dose 3 x 50 u/kg b.w. (mean during 4 months 65 +/- 24 u/kg m.c. 3 times weekly). Patients from HDb group received r-Epo during 12 months only s.c. with initial dose 2000 u three times per week (mean during 12 months 26 +/- 4 u/kg m.c. 3 times weekly). Dose of r-Epo was changed accordingly to HGB concentration to keep it between 10-12 g/dl. Blood morphological parameters were monitored weekly using hematological autoanalyser Technicon H1, simultaneously an iron status indicators as iron, transferrin and ferritin were measured. An increase of HGB concentration, erythrocytes count and Ht value was observed in all patients (I-HGB 10.1 +/- 2.9, II-HGB 9.2 +/- 1.6).(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗
PubMed1994

[Effect of treatment with erythropoietin (r-EPO) on hemodynamics of the cardiovascular system in patients with chronic renal failure (c.r.f.)].

Patients with chronic renal failure (c.r.f.) are at high risks of death from cardiovascular diseases. It was found that successful treatment of anemia could positively influence not only patients well being but also caused some unfavourable hemodynamic changes. The aim of the study was the estimation of some morphological and functional parameters of left ventricle (lv) in dialyzed and predialyzed patients treated with r-Epo. Two groups of patients with c.r.f. were studied. The I group of 10 dialyzed patients (6 W, 4 M, mean age 34 +/- 11, weight 55 +/- 9 kg), and the II group of 9 pre-dialyzed patients (6 W, 3 M, mean age 50.6 +/- 10, weight 63 +/- 14 kg). r-Epo (Eprex Cilag AG) was administered during 6 months s.c. The I group was given initial dose 3 x 2000 u per week (mean dose 24-46 u/kg b.w./per week, the II was on 3 x 2000 u per week (mean dose 24-46 u/kg b.w./per week) subcutaneously. The doses were adjusted by Hb level in order to keep it within limits (10-12 g/dl). Hematological parameters were monitored once a week by Technicon H1. Morphology and function of the lv were evaluated using echocardiographic measurements performed by Irex IIIA system. According to prescriptions of ASE the following parameters have been assessed: lv dimension, thickness of posterior wall in diastole and systole and thickness of interventricular septum in diastole.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗
PubMed1994

[P1 blood group, secretion status and susceptibility to asymptomatic bacteriuria in diabetes].

Blood-group antigens found on uroepithelial cells and in the secretions may affect bacterial adherence and thereby the predisposition to urinary tract infection. We determined P1, Lewis-blood-group phenotype and secretor status in patients with diabetes mellitus: 12 with asymptomatic bacteriuria and 7 without its presence. There was no difference between the two groups in the distribution of the P1 phenotype. There was also no statistical difference in the distribution of the Lewis phenotype and secretor status, although there appeared to be general trend of higher number of Le (a+b-) phenotype and non-secretors present in the asymptomatic bacteriuria group. Further studies are necessary to determine the role of blood groups and secretor status in the pathogenesis and susceptibility to urinary tract infection.

Adult↗
PubMed1994

[Dynamics of changes in lipid metabolism during the first year after kidney transplantation].

Dyslipidemia is one of the first metabolic dysfunction observed among patients with end stage renal disease. It can also induce acceleration of renal tissue damage. Kidney transplantation may cause recovery of some dysfunction in lipid metabolism while influencing deterioration of others. The aim of this study was to monitor dynamics of basic lipid parameters in the first year after kidney transplantation. The sample included 25 patients (9W, 16M), aged 18-59, avg. 36. We have measured concentration of the following parameters in blood serum: triglycerides (TG), total cholesterol (CH-C) and apolipoprotein B (Apo B). Simultaneously, functions of transplanted kidney were tested with use of routine methods. The immunosuppressive treatment of patients followed the scheme: cyclosporine + prednisolone + azathioprine. The treatment influence on lipid disorders was measured by relevant correlation coefficients. The obtained results point to the observation that in the first year after kidney transplantation the TG concentration gradually decreases, with simultaneous continuous increase of CH-C concentration, mainly due to LDL concentration increase. No influence of immunosuppressive treatment on lipid parameters was observed. However, lipid dysfunction, especially TG, correlated with kidney function.

Adolescent↗
PubMed1994

[Development of dialysis therapy in Poland during the decade 1984-1993].

Data concerning status of dialysis therapy in Poland during decade 1984-1993 were analysed. It was found that: 1. number of dialysis units increased two times (54-105), 2. number of dialysis stations raised 2.5 times (294-812), 3. number of patients treated with maintenance dialysis was increased 3.5 times (962-3783). These data showed dynamic development of this method of renal replacement therapy in Poland. However, in Poland acceptance rate dto dialysis therapy is still not satisfactory (30-35%). The Programme of the Country Committee for the Promotion of Nephrology based on the central founding system for the renal replacement therapy provides that by the end of 1995 it will be possible to treat 50% of patients with chronic uraemia. Continuous development of different methods of renal replacement therapy (hemodialysis, continuous ambulatory peritoneal dialysis, renal transplantation) is necessary for achieving possibilities compared with developed countries.

Health Promotion↗
PubMed1994

[Acquired cysts of the kidney in patients treated with long-term dialysis].

There are many reports about development of AC in patients on dialysis therapy (DT) and about their pathophysiological consequences. The aim of our studies was to determine the prevalence of AC in patients treated with hemodialysis in dialysis centre in Gdańsk. We also tried to asses relationship between the presence of AC, age and sex of the patients, the duration of DT and level of haemoglobin (Hb), hematocrit (Ht), red blood cells (RBC) and the prevalence of hypertension (H). Renal ultrasound scan was performed in 54 patients, among them 26 (48.5%) had acquired cysts. No correlation was found between presence of cysts and age, sex and nature of the underlying renal disease. There was a positive correlation between the prevalence of AC and the duration of DT (DT < 1 year--36.8/, DT < 3 years--42.8%, DT > 3 years--59%), it did not, however, reach statistical significance. Haematological parameters did not differ significantly between both groups, AC--patients, however, received more blood transfusions (2983 ml/year vs. 2485 ml/year). Similarly, there were no differences in systolic and diastolic blood pressures (mean yearly values before and after HD) between both groups, but in AC+ group more patients needed intensive treatment with hypotensive drugs. Our results indicate that the prevalence of AC increases with the duration of DT. The possibility that the presence of AC may influence severity of anaemia and hypertension is suggested.

Adolescent↗
PubMed1994

[Tuberculosis--an increasing risk for patients treated with long-term hemodialysis].

UNLABELLED: In the recent years an increase in the incidence of tuberculosis (TB) has been observed world-wide, including Poland. In the Department of Nephrology of Gdańsk School of Medicine, an increase in the incidence of TB has been observed among patients undergoing maintenance hemodialysis (HD). The aim of this work was to analyse the natural history of TB infection in this group of patients. Over the last seven years TB was diagnosed in 9 patients (5 female, 4 male) out of 171 patients on HD (5.2%). Seven of those were diagnosed in the last three years. The average age of patients with TB was 47.2 years. In three patients the clinical symptoms of TB has appeared during the first year of hemodialysis treatment (average 5.6 months), in the rest the mean period of dialysis before the TB diagnosis was 60 months. The TB was extrapulmonary (lymph nodes, pericardium and bones) in 5 patients. In most cases the clinical symptoms of TB were present, however, one patient was asymptomatic. Four cases were confirmed microbiologically and/or histopathologically. All patients treated with antituberculous drugs showed clinical recovery or cure, however in six patients the anti TB treatment was complicated by adverse drug reactions. One patient died and TB was diagnosed post mortem. In two patients who had had lymph nodal TB 2 and 6 years earlier, we now observed pulmonary TB. There were no cases of TB among hemodialysis unit staff. CONCLUSIONS: There is a increasing incidence of TB in population of HD patients.(ABSTRACT TRUNCATED AT 250 WORDS)

Adolescent↗
PubMed1994

[The role of the adrenergic nervous system in control of extrarenal potassium disposal in acute renal failure--unclear pathophysiological and clinical problem].

The effect of catecholamines on the regulation of extra-renal potassium homeostasis is well known in some pathological conditions such eg. chronic renal failure. However, the role of catecholamines on potassium homeostasis in acute renal failure has not been established yet. There are only scarce amount literature on this issue showing that both clinical and experimental acute renal failure plasma catecholamines are elevated. Presumably, acute renal failure associated hyperkalemia is ameliorated by raised plasma catecholamine concentration.

Acute Kidney Injury↗
PubMed1994

[Bone tuberculosis in a hemodialyzed patient--a difficult diagnostic problem].

Recent observations indicate quite high incidence of tuberculosis (tbc) in haemodialysis population. But there are really only few reports of arthritis the infection. Mycobacterial process in this location may imitate many other pathological states. Our report refers to 45-year-old man with right knee the infection and the peri-arthritic tissue, which developed after 8 years of renal replacement treatment. No evidence of the was noted before. Chronic pain, swelling and instability of the knee led finally to surgical extraction of diagnostic material, which contributed to final diagnosis. We consider this report to be important because of only few reported cases of the arthritis. Additionally unnecessary delay in commencement of treatment may lead to bone destruction.

Humans↗
PubMed1994

Effect of epinephrine infusion on plasma potassium and its urinary excretion in rats subjected to subtotal nephrectomy.

Extrarenal potassium handling plays pivotal role in potassium homeostasis and is regulated by several hormones including epinephrine. The aim of this study was to look how epinephrine affects both extrarenal and renal potassium handling in rats with chronic renal failure. In subtotally nephrectomized rats, epinephrine (0.05 micrograms/kg per h) plus KCl (0.5 mmol/kg per h) were infused i.v. Plasma potassium and its fractional urinary excretion were measured simultaneously in five clearance periods. Each clearance period lasted 20 min and glomerular filtration rate was estimated as inulin clearance. Regardless of epinephrine infusion plasma potassium as well as fractional potassium excretion were higher in rats with chronic renal failure than in controls (shame--operated). It was concluded that the effect of epinephrine on both extrarenal and renal potassium handling was ameliorated in rats with chronic renal failure.

Animals↗
PubMed1994

Importance of iron status monitoring during erythropoietin treatment in uremic predialysis patients.

Since recombinant human erythropoietin (r-Hu EPO) has been introduced to the treatment of anemia in uremic patients the issue of optimal therapy appeared. For proper erythropoiesis not only erythropoietin but also iron, folic acid and B12 vitamin are needed. Iron deficiency is one of the most common factors causing resistance to r-Hu EPO in uremic patients, so its recognition and eventual supplementation is required for optimal hemopoietic response. The aim of presented study, besides monitoring hematological changes, was to measure iron status parameters such as iron, transferrin, ferritin and percentage of hypochromic erythrocytes and estimation of their usefulness in monitoring iron deficiency during r-Hu EPO treatment.

Adult↗