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Biomedical subjects

B Rushton

Publications and source records attributed to B Rushton.

24 records · Page 2Linked to original sources
PubMed1977

Ovine fascioliasis following reinfection.

Sheep were reinfected with matacercariae once. Half were treated with anthelmintic one week before reinfection. Compared with a primary infection, the reinfecting flukes in most seemed to migrate faster through the liver although in one treated sheep migration seemed to be longer and more destructive. Migrations extended into areas little affected by the primary infection thus producing more widespread fibrosis. Although a temporary retardation in fluke growth rate occurred, there was no reduction in the numbers of flukes recovered. Flukes killed by anthelmintic formed large granulomata.

Animals↗
PubMed1976

The assessment in sheep of an inactivated vaccine of parainfluenza 3 virus incorporating double stranded RNA (BRL 5907) as adjuvant.

The serological responses of conventionally reared sheep were compared after vaccination with inactivated parainfluenza 3 (PI3) virus incorporated in three different adjuvants. Inactivated PI3 virus with the double-stranded RNA, BRL 5907 in an oil emulsion was shown to stimulate higher serum antibody titres over the first 5 weeks after vaccination than virus with and without BCG emulsified in oil. The ability of this vaccine to protect specific pathogen-free lambs against challenge with PI3 virus was examined in a second experiment. In this experiment the vaccine stimulated virus neutralizing and haemagglutination inhibiting antibodies in the serum. After intranasal and intratracheal inoculation with PI3 virus at challenge, vaccinated lambs showed no clinical illness and virus isolation was confined, except in one lamb, to the first two days. In contrast, unvaccinated lambs developed respiratory disease and virus was isolated daily for 7 days after challenge.

Adjuvants, Immunologic↗
PubMed1976

Morphology and classification of subdivisions of the intrahepatic vascular and biliary systems in sheep.

Tensol casts and histology were used to demonstrate sub-divisions of the portal and hepatic veins, and arterial and biliary systems. Portal and hepatic venous subdivisions were most readily identified. Based upon size, location, sequence of branching and histological characteristics a nomenclature for the sub-divisions of the portal vascular system was proposed. The names of distributing, primary, terminal, secondary (long and short) and tertiary veins were adopted to identify portal veins branches. The same criteria allowed the identification of three hepatic vein branches, central, sublobular and hepatic; the central hepatic veins and to a much lesser extent the sublobular hepatic veins drained the sinusoids. Casts of the arterial system demonstrated the arterial blood supply to the biliary system, to the sinusoids and portal vein vasa vasorum but they were of little use in identifying subdivisions. Arterial subdivision identification is possible by using accompanying portal veins as morphological markers and designating the subdivision after the vein. This approach is also applicable to the biliary system and provides a more accurate means of subdivision identification than does the broader division into ductules, intermediate and large ducts.

Animals↗
PubMedDate not supplied

Structure of the nucleosome core particle at 7 A resolution.

The crystal structure of the nucleosome core particle has been solved to 7 A resolution. The right-handed B-DNA superhelix on the outside contains several sharp bends and makes numerous interactions with the histone octamer within. The central turn of superhelix and H3 . H4 tetramer have dyad symmetry, but the H2A . H2B dimers show departures due to interparticle associations.

Animals↗