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Biomedical subjects

B Roussel

Publications and source records attributed to B Roussel.

99 records · Page 6Linked to original sources
PubMedDate not supplied

[Action of clovoxamine on the sleep of depressed patients. "Polygraphic recordings"].

This study reports the action of clovoxamine, a non-tricyclic non IMAO antidepressant, on the sleep parameters of five patients suffering from primary depressive illness. Before treatment all subjects presented an EEG syndrome of primary depressive sleep disorder (decreased paradoxical sleep latency). Sleep recordings were made after 1 month and 3 months of monotherapy with clovoxamine. PS latency increased to normal values, sleep efficiency improved and wake time decreased, and, more remarkably, paradoxical sleep was not suppressed by clovoxamine.

Adult↗
PubMedDate not supplied

[Selective binding in vitro of a modified form of the C3 component of complement to human erythrocytes].

C3 was bound to human erythrocytes from autologous plasma or from serum brought to low ionic strength (mu less than or equal to 0.03) and pH between 4.0 and 5.0, then subsequently incubated with erythrocytes (50/1, v/v) for 20 min at 0 degree C. This capacity was preserved up to 72 h by prolonged incubation at 20, 25 or 37 degrees C, whereas it was quickly lost by incubation at 0 degree C. C3 binding did not require complement activation and was not observed with neuraminidase-treated erythrocytes. Crossed immunoelectrophoretic analysis of the pretreated serum or plasma revealed that a fraction having more cathodal migration than that of native C3 was generated upon incubation in the above-mentioned conditions. This fraction appeared able to selectively bind to the erythrocytes. Cell-bound C3 reacted positively to antisera against C3a, C3c, C3d or native C3; they rosetted positively with EAC3b, clearly showing that this C3 binding was not dependent on the proteolysis of C3 and that it concerned the acceptor sites on the cells, since C3b receptors were free. The functional significance of this C3 binding was also investigated: EC3 were not able to lyse through the alternative pathway, whereas lysis clearly increased when C3 was found to AET-treated erythrocytes. This finding, together with the modulation in the capacity of EC3 or E(AET)C3 to form an alternative pathway convertase by antibodies to C3c or C3d, strongly suggests a contribution of bound C3 to such a convertase. In contrast to "C3b-like" C3, this modified C3 was able to bind to acceptor sites on erythrocytes but, like the former, it retained the capacity to form an alternative pathway convertase. In this light, it may represent an intermediate between C3 and "C3b-like" C3.

Complement Activation↗
PubMedDate not supplied

Internal temperature variations during the sleep-wake cycle in the rat.

This study attempted to explain the variations of internal (brain and subcutaneous) temperature in the rat as a function of sleeping and waking. Temperature variations in cerebellum and hypothalamus were related to the changes in local cerebral blood flow (CBF) measured chronically with a thermal clearance method. CBF was stable and at a high level during slow wave sleep (SWS), decreased at the beginning of each wake (W) and paradoxical sleep (PS) phase, but tended to overshoot at the end of the PS phase. Subcutaneous temperature was related to the whole body thermogenesis (VO2) and to the sensible heat loss by radiation, convection and conduction. VO2 increased during W, decreased and plateaued during SWS, and was at a minimum level during PS. Sensible heat loss decreased during W, increased during SWS, and generally rose abruptly during PS. These variations in body and brain heat gain and heat loss are in agreement with the local temperature variations during sleeping and waking. The concomitant variations in vigilance states and internal temperature led to an apparent close relationship between the circadian rhythms of these variables, although their exact degree of liaison was not established.

Animals↗
PubMedDate not supplied

[Value of NMR spectroscopy in exploring the cerebral metabolism of patients affected by Alzheimer's disease].

Besides imaging NMR can obtain spectrum reflecting brain tissues components able to resound. Some of these take an active part in a CNS metabolism: such are H (in water) and P (in MPA-TPA, etc.). This new investigating method already showed interest in vitro (tissues cultures) and in vivo (muscular metabolism) studies. Its application to cerebral metabolism studies are going to spread thanks to technological advances (magnetic field more powerful: air gap broad enough for human head passage). The first results of this investigation, in 5 SDAT patients diagnosed with respectively international inclusion criteria (NINCDS-ADRDA) and exclusion ones (such as XR Scan and SPECT exploration), are presented; they are divided into two different groups showing PME (phosphomonoesters) peak dropped to 3.2 or 1.8 in one part, and raised to 15.5 till 27 ppm (parts by million: conventional unit dealing with substances concentration) as the normal range is set at about 7 +/- 4.5 ppm. Such PME changes have showed in an other B. Roussel's study to be a good biological index correlated with the age and the CNS state; these results seem to be of interest, mainly (that must be emphasized) as this technique is quite non intrusive and non irradiating.

Aged↗