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Biomedical subjects

B Roussel

Publications and source records attributed to B Roussel.

At least 73 records · Page 4Linked to original sources

[Duplication of the bladder by a frontal septum. Apropos of a case].

The authors report a case of total bladder duplication by frontal septum. The anterior bladder was functional. The posterior bladder was non-functional, and drained a destroyed kidney. Analysis of the rare cases reported in the literature suggests that this malformation should be differentiated from other bladder duplications, because it may be a giant ureterocele. In conclusion, the authors stress the simplicity of the management, consisting of resection of the septum and nephrectomy of the non-functional kidney.

Child, Preschool↗

[Laurence-Moon-Bardet-Biedl syndrome, chronic diffuse tubulo-interstitial nephritis and liver involvement].

The authors report the case of a 6-year-old girl with Laurence-Moon-Bardet-Biedl syndrome and chronic tubulo-interstitial nephritis with glomerulosclerosis requiring chronic peritoneal dialysis, then haemodialysis. One year later, minimal hepatic involvement occurs, leading to portal hypertension. The liver biopsy reveals periportal fibrosis with many small bile ducts.

Bile Ducts, Intrahepatic↗

Effect of ambient temperature on the sleep-waking cycle in two strains of mice.

The sleep-waking cycle was studied in two strains of mice during continuous exposure over 3 weeks to an ambient temperature of 34 degrees C or 10 degrees C. As compared to the 25 degrees C control period, C57BL/6 mice showed at 34 degrees C a mean increase of 25% in slow-wave sleep (SWS) particularly during the night. Paradoxical sleep (PS) was also increased by 58% during the exposure period particularly during the night and this resulted from an increase in the number of PS episodes. At 10 degrees C SWS was decreased by 9% only during the first week of exposure, whereas PS was reduced by 24% throughout due to a decrease in the number of PS episodes, although their duration increased. The acrophase of the circadian rhythms was not affected by the changes in ambient temperature. In the BALB/c strain at 34 degrees C SWS and PS were increased only during the first week by 13% and 77%, respectively. At 10 degrees C SWS was decreased by 7% throughout and PS was decreased by 36% due to a reduction in the number of PS phases during the light period. On returning to 25 degrees C, a rebound in PS confirmed the PS deprivation in the cold in both strains.

Animals↗

Monoclonal IgM with anti-muscle tissue activity in a patient with Waldenström's macroglobulinaemia: secretion of identical immunoglobulin by the established lymphoid cell line.

The monoclonal IgM kappa protein from a patient with Waldenström's macroglobulinaemia displayed antibody like activity against muscle and alpha-actinin. An Epstein-Barr virus associated lymphoid cell line, spontaneously established from blood lymphocytes, has been continuously secreting an immunoglobulin of the same isotype, isoelectric focusing spectrotype and reactivity; the cell line is probably leukaemic in origin since all cells display the translocation t (1; 19) and are aneuploid. We suggest these two monoclonal immunoglobulins have a common malignant origin.

Aged↗

[Contribution of ultrasonics in the evaluation of abdominal tumors in children].

Twenty-eight children with abdominal tumors were examined ultrasonically. Real-time ultrasonography proved particularly useful in infants. In most cases ultrasonography shortened the diagnostic procedure by giving accurate images of the tumor's limits, size, contents, and origin. The method yielded an overall diagnostic accuracy rate of 89%. Moreover, ultrasonography is a reliable and safe means of monitoring abdominal tumors during and after therapy. In 1981, plain roentgenograms, intravenous urography with cavography and ultrasonography should be sufficient in the standard radiologic approach of most children with abdominal tumors.

Abdominal Neoplasms↗

Changes in human heart rate during sleep following daily physical exercise.

Four fit, healthy young men (aged 20) volunteered for the experiment. After a 5 day control period, they marched for 6 consecutive days (from 09:00 h to 17:00 h) for 34 km/day at a speed of 6 km/h, with an energy expenditure of 35% of individual VO2 max. A recovery period of 5 consecutive days began immediately after the exercise period. Sleep records and electrocardiograms were taken every night during the three periods from 22:00 h to 06:00 h. During the exercise period the night time heart rates increased by about 10%, compared to the previous control condition, and returned to normal during the recovery period. The relation between heart rate changes and sleep stages remained identical throughout the three experimental periods. Three subjects showed an increase in heart rate during paradoxical sleep, compared to the preceding slow wave sleep, while one subject experienced the reverse. The tonic increases in heart rate are discussed in relation to changes in body temperature, sleep patterns, blood composition and hormonal status induced by the physical exercise performed.

Adult↗

Heart blocks during sleep: a case report in a healthy subject.

Cardiac arrhythmia was fortuitously discovered during an experimental sleep recording in a healthy 50-year-old man. a 24 hr electrocardiographic (ECG) monitoring revealed the prevalence of these abnormalities during sleep and their absence during the awake period. Sleep and ECG were recorded during 4 consecutive nights. Numerous (500-1, 100 events/night) heart blocks and sinus pauses occurred 60-80 min after going to bed. They were never observed during awakenings and were exacerbated during paradoxical sleep. The atrioventricular blocks were of the Wenckebach-Luciani type. No other abnormality was found. These conduction abnormalities are discussed as possibly due to phasic increases in vagal firing, which during paradoxical sleep would be superimposed on the tonic increase in heart rate.

Electrocardiography↗

[Localized form of xanthogranulomatous pyelonephritis in a child. Case report].

The authors report the case of a 4 1/2-year-old boy with a localized xanthogranulomatous pyelonephritis. Review of the literature shows that this rare condition is often misdiagnosed before surgery, a preoperative diagnosis of Wilms' tumor being proposed instead of the exact one which is of benign prognosis. The pathogenesis is unknown.

Child, Preschool↗

Human sleep and adrenal individual reactions to exercise.

Six fit men, aged 20, participated in the 16 day experiment. After a 5 day control period, the subjects marched on 6 consecutive days (from 09:00 h to 17:00 h) for 34 km/day at a speed of 6 km/h, with a backpack adjusted to complete a 35% of individual VO2 max energy expenditure. Control conditions were resumed for a 5 day recovery period. Sleep records were taken every night from 22:00 h to 06:00 h. Urinary 17-hydroxycorticosteroids (17-OHCS) were analysed from a 09:00 h to 17:00 h sample and from overnight urines. Two groups of subjects were defined by their responses to exercise. Four subjects exhibited an increase in stage 3 during the last third of the exercise nights (mean: 163.8 +/- 7.3% of control values) without any change in their adrenal response. Two subjects had no change or a slight decrease in stage 3 but showed increased 09:00--17:00 h 17-OHCS urine excretion (mean: 147 +/- 13% of control values). Sleep latencies were decreased in both groups. However, the 2 subjects of the second group exhibited increased restlessness as measured by the levels of wakefulness, stage 1 and EMG activity. In all subjects, paradoxical sleep was not altered, along with an unchanged all-night excretion of 17-OHCS. It is suggested that differences in adrenal responses to exercise may be responsible for differences in sleep quality. This could explain the discrepancies encountered in the literature about sleep variations after physical exercise.

17-Hydroxycorticosteroids↗

Thermogenesis and thermolysis during sleeping and waking in the rat.

Thermogenesis (VO2), sensible heat loss and subcutaneous back temperature were recorded simultaneously during sleeping and waking in both intact and depilated rats at Ra ranging from 21--28 degrees C. VO2 increased during wakefulness (W), decreased and plateaued during slow wave sleep (SWS) and then decreased 10% with each paradoxical sleep (PS) phase. Sensible heat loss, which represented about 90% of the heat production, increased and plateaued during SWS, decreased in W and generally rose abruptly (+40%) during PS. After removal of the fur the mean levels of VO2 and sensible heat loss were increased by 20--50% and returned to normal values within two weeks, although their variations related to stages of sleep were unchanged. These results concerning thermogenesis and thermolysis are in agreement with the variations of body temperature (brain excluded) during sleeping and waking.

Animals↗

[Renal lesions in congenital syphilis. A case report].

The authors describe a case of congenital syphilitic nephropathy in an infant. The review of the reports in the literature shows many similarities of this congenital disease with the syphilitic nephrotic syndrome in the adult. The prognosis is favorable provided the diagnosis is made sufficiently early. Histological studies utilizing light-, electron- and immunofluorescence-microscopy gave results consistent with extramembranous glomerulonephritis with possible evolution towards endo- and extracapillary proliferative glomerulonephritis. This is one of the rare renal diseases with a known antigen.

Antigens, Bacterial↗