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Biomedical subjects

B Roncoli

Publications and source records attributed to B Roncoli.

8 recordsLinked to original sources

Decrease of granulocyte-macrophage colony-forming units during high dose medroxyprogesterone acetate treatment in advanced breast cancer.

We treated 18 post-menopausal women with advanced breast cancer with medroxyprogesterone-acetate 1000 mg p.o. daily. The study of granulocyte-macrophage colony forming units (GM-CFU) performed monthly, and peripheral white blood cell count showed an increase of granulocytes not statistically significant and a progressive decrease of GM-CFU that could protect marrow from chemotherapeutic agents or interfere with the myelosuppression of cytotoxic drugs.

Breast Neoplasms

Selective myeloid aplasia: a long-lasting presentation of an unusual hairy cell leukemia variant?

A rare aleukemic myeloaplastic presentation of hairy cell leukemia (HCL) is described. The patient was observed for 11 years and presented a clinical picture suggestive of pure white cell aplasia for seven years. Hairy cells (HC) were first discovered in the bone marrow, then occasionally in the blood during the last four years. A brief course of low-dose alpha interferon promptly induced prolonged remission of neutropenia. In our opinion, this case, as few others described till now, should be considered a rare HCL variant, an understanding of which offers an important clinical opportunity for investigating the myeloid inhibitory activity of hairy cells.

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