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Biomedical subjects

B Romański

Publications and source records attributed to B Romański.

At least 19 recordsLinked to original sources
PubMed1999

[The frequency of atopy in lung cancer patients].

The controversial opinions on adverse correlation between atopy and incidence of lung cancer made us to undertake the research in that field in patients, treated in Department of Lung Diseases of University School of Medicine in Bydgoszcz. In 45 histologically diagnosed lung cancer patients in III and IV stage of the disease the tendency to atopy was assessed. In above mentioned patients the serum level of total IgE, the number of eosinophyls in peripheral blood and skin tests with popular allergens such as: home-dust, feather, grass particles, fungus and mould. It was established, that atopy in 25% of lung cancer patients was observed. That percents similar in persons without cancer burden. These findings suggest, that pathologically increased immunologic reactions, observed in atopic patients do not protect from lung cancer. From the other hand, the results of these examinations suggest also, that depressions of immunologic reactions, connected with lung cancer are selective in their nature.

Adult↗
PubMed1998

[Eosinophilic activation based on measurements of eosinophil cationic protein in patients with acute myocardial infarction and patients with angina pectoris].

Increased activation of polymorphonuclear neutrophils in the wideness of irreversible myocardial injury was described by many authors. Released proteolytic enzymes may cause deliquescence of necrotic muscle tissue and attenuate collagenic structure of myocardium, lead to endothelium damage and generate free oxygen radicals. Eosinophilic leucocytes reveal also enhanced proinflammatory activation. They take participation in inflammatory and immunologic reactions, among others, by producing and releasing many biologic mediators. One of the most important and powerful mediators is eosinophil cationic protein (ECP), the specific marker of eosinophil activation in vivo. We studied 17 patients (pts) with acute myocardial infarction (MI) and 21 pts with angina pectoris (AP). The plasma concentrations of ECP and the number of eosinophils in peripheral blood were measured 3 times-near before beginning of the treatment, and on the 4-th and 8-th day of MI. During the first 4 days measurements of CK-MB every 6 hours were made. We observed the significant increase of eosinophils and ECP correspondingly on the 8-th and 4-th day, when compared to the first day of MI (p < 0.05) and the patients with AP (p < 0.01). Despite tendency, the significant correlation of eosinophils and ECP values was not obtained (r = 0.36). In the group of patients with AP the eosinophil and ECP values were significantly higher at the pts with unstable angina, when compared to pts with stable angina (p < 0.001).

Angina Pectoris↗
PubMed1998

[Some clinical symptoms and allergens on asthma-prurigo syndrome].

The group of 146 patients suffering from asthma-prurigo syndrome (85 adults and 64 children) have been inquired in many various clinical centers. It was established that in 79.6% of the patients the first symptoms of illness appeared already in infancy and only 28.2% of the patients had negative familiar anamnesis on the allergy. In 73.2% of the patients with asthma-prurigo syndrome the symptoms of atopic dermatitis persisted longer than asthma symptoms and in 89.9% of them asthma-prurigo symptoms accompanied other form of allergic diseases. The most important causal allergens provoking asthma-prurigo symptoms were: house dust (in 64.4% of the patients), chocolate (in 42.2%), cat epithelia (in 40.2%) and cow milk proteins (in 29.5% of the patients).

Adult↗
PubMed1998

[Changeability of respiratory tract and skin symptoms in patients with asthma-prurigo syndrome under the influence of emotional and environmental factors].

In a group of 228 patients suffering from asthma-prurigo syndrome the influence of emotional state, permanent residence and season time on dynamic of the clinical symptoms were studied. The evaluation of emotional state in 80 adult patients was carried-out by means of Eysenck Personality Inventory. The emotional state had less negative influence on the exacerbation of the symptoms upon children then in adults (especially on their skin symptoms). It was confirmed that the patients with high level of neurotic symptoms revealed easier the exacerbation of asthma and skin disorders under the influence of emotional stress. The climatic treatment on the sea-side was more efficient for them than any mountain climatic cure, especially in the treatment of airways symptoms. Similarly, the summer season brought the relief of their symptoms from both the respiratory and skin symptoms.

Adult↗
PubMed1997

[Early post myocardial infarction syndrome--a trial of assessment based on clinical course and immunologic tests].

The study analysed clinical and immunological course of 22 patients (aged 56.3 +/- 9.5) with fever (38.5 degrees C) and greatly increased erythrocyte sedimentation rate (ESR) in the first week after myocardial infarction. The control group consisted of 25 patients (aged 50.7 +/- 11.2) without inflammatory and infectious diseases. Clinical courses of the disease, chest x-ray, echocardiography, leucocytosis and serial CK-MB levels were analysed. The immunological investigations involved quantitative estimation of IgG, C3 complement, C4 complement and the identification of T and B lymphocytes on the basis of the rosette tests A, E and EAC. Post myocardial infarction syndrome (PMIS) manifested by fever and greatly increased ESR we observed in 64% of examined patients, but fully manifested PMIS in 14% with tendency to recurrences. We found the differences in immunological examinations compared to the control group. Pericardial effusion occurred in 64% of the patients. The treatment with corticosteroids brought dramatic relief of the symptoms with objective improvement of clinical condition. Patients with high temperature with accompanying greatly raised ESR in the first week after MI may demonstrate abortive form of the post myocardial infarction syndrome.

Aged↗
PubMed1995

[Efficacy of flunisolide in treatment of patients with bronchial asthma].

In 30 patients with bronchial asthma an influence of flunisolid (Bronilide) on spirometric values, bronchial reactivity and pathological signs was evaluated. No changing in spirometric values and bronchial reactivity and decrease complaints during the treatment with higher doses of Bronilide were noticed. No significant side effects were observed.

Adolescent↗
PubMed1994

[Evaluation of heart function during endoscopic examination of the upper gastrointestinal tract together with a trial of direct provocation of the sensitizing allergen--initial report].

The heart function was evaluated during endoscopy examination connected with the gastric challenge with the sensitizing allergen. The study involved 13 patients with diagnosed pollinosis and without any disorder of the cardiovascular system. The heart function was evaluated by Holter monitoring, performed both in 24 hours of control before endoscopy examination and in 24 hours of exposure during and after gastric challenge with the sensitizing allergen. In all cases, there was no important heart dysfunction, in spite of positive results of provocation confirmed by histopathological and immunological examinations.

Adult↗
PubMed1994

[Clinical characterization of "asthma-prurigo" syndrome with emphasis on risk factors].

In a group of 228 patients with Asthma-Prurigo syndrome in 82.5% of patients the onset of skin lesions was earlier than the onset of asthma. It was found that the early onset of atopic dermatitis suggests the greater probability of subsequent asthma. In 88.6% of patients also other allergic diseases were diagnosed, and rhinitis allergica was observed most frequently. In the investigated group of patients urticaria chronica idiopathica or physical urticarias were not observed. Among 228 patients with Asthma-Prurigo syndrome, 74.6% of patients pointed to house dust as one of the most frequent causative factors. The house dust similarly to other inhalant allergens, somewhat more frequently had influence on the course of atopic dermatitis than on the course of asthma. Contrary to this observation according to patients food allergens (milk, eggs, fish, chocolate) aggravated or induced the relapses of skin lesions much more frequently than asthma. It was shown how often patients noticed adverse reactions due to penicillin and sulphonamides.

Adult↗
PubMed1993

[Therapeutic examination of efficiency for vaccine desensitization with grass pollen catalet].

The results of a 5-year studies on the therapeutical efficiency of Catalet--desensitization vaccine containing grass pollen antigens adsorbed on aluminium hydroxide--are discussed. Catalet vaccine is manufactured by Sera and Vaccines Works in Kraków in the doses of 25 PNU/ml, 250 PNU/ml, 2500 PNU/ml, and 10,000 PNU/ml. It was found that Catalet possesses a strong antigenic properties and enables complete or partial intensivity to grass pollens in the majority of treated patients. Therapeutical efficiency of Catalet has markedly been different than that of placebo, and had expressed fully following a two- or three-year treatment.

Adolescent↗
PubMed1992

[Studies on the possibility of desensitizing patients sensitive to plant pollens and house dust by an oral route].

Oral hyposensitization was carried out in 26 patients with pollinosis and in 67 patients sensitive to house dust with all year symptoms of allergic disease of the skin, airways or conjunctivitis. The patients were hyposensitized with grass pollen extracts and house dust produced by Lab. Sevac. The pollen allergen was administered before the pollinating season, in increasing doses during 18 weeks. The following concentrations were used: 0.1 PNU, 1.0 PNU, 10 PNU, 100 PNU, and 1000 PNU. The house dust allergen was administered in the same manner, using the same concentrations and time during autumn and winter. In the group of patients with plant pollinosis 10 out of 26 did not experience any symptoms of the disease after hyposensitization. In 9 further patients the symptoms were milder. In the group of 44 patients with atopic dermatitis sensitive to house dust, a complete cure was seen in 62% of the patients. In further 25% milder symptoms were observed. In the group of 11 patients allergic to house dust and with the asthma-prurigo syndrome, the respiratory and dermatologic symptoms resolved completely or diminished in 3 and 6 patients respectively. In the group of 7 patients with dermatitis and full year rhinitis, complete resolvement of symptoms was seen in 2 patients and diminished symptoms in 3 cases. In the group of 4 patients with conjunctivitis full resolvement of symptoms was observed in 3, while partial in 1. Only in 3 out of 93 treated subjects intolerance of this therapy was found.(ABSTRACT TRUNCATED AT 250 WORDS)

Adolescent↗