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Biomedical subjects

B Rogers

Publications and source records attributed to B Rogers.

At least 55 records · Page 3Linked to original sources
PubMed1997

Comparison of serum PSMA, PSA levels with results of Cytogen-356 ProstaScint scanning in prostatic cancer patients.

BACKGROUND: Stored serum from clinical trial cases undergoing ProstaScint (CYT-356) scanning were available for Prostate Specific Membrane Antigen (PSMA) assay. Prostate Specific Antigen (PSA) levels had already been determined. This provided an opportunity to see what correlations existed between the serum markers and the ProstaScint scan. A group of patients had the studies preprostatectomy, whereas another group had the studies postprostatectomy. METHODS: The scan results, serum PSA, serum PSMA, and clinical data were separately analyzed. PSMA serum levels were determined by Western blot. RESULTS: Preoperatively, radical prostatectomy patients showed a correlation between serum PSA or PSMA levels and the ProstaScint scan in the total group (n = 86), or in an untreated group (n = 38). Preoperatively, PSMA correlated with the pathological stage, whereas PSA correlated with the scan. Postoperatively, only PSMA serum levels correlated with the scan in an untreated group (n = 40). CONCLUSIONS: Preoperatively or postoperatively, Western blot PSMA serum levels predict the stage of disease or local, regional, or distant metastases, as shown by ProstaScint scan. Both the scan and the serum tests provide prognostic information and evaluate the extent of disease to a more significant degree than previously possible.

Adult↗
PubMed1997

Disparity modulation sensitivity for narrow-band-filtered stereograms.

Stereo thresholds for 84% correct detection of sinusoidal disparity corrugations depicted by narrow-band-filtered random dot stereograms were determined for surfaces as a function of (i) luminance center spatial frequency and (ii) disparity modulation frequency. In addition, supra-threshold depth matching functions for two amplitudes of peak-to-trough depth were determined using similar stimuli. Disparity thresholds followed a U-shaped function when plotted against luminance centre spatial frequency from 1 to 8 c/deg. The threshold functions for the three highest corrugation frequencies (ranging from 0.25 to 1 c/deg) formed a single family with a similar bandpass shape and a peak sensitivity at ca 4 c/deg. At the lowest frequency of depth modulation (0.125 c/deg) the shape of the luminance spatial frequency threshold function showed a reduced sensitivity to depth modulations when portrayed by patterns with high luminance centre frequencies (8 c/deg). The similarity of the threshold functions reveals luminance and corrugation frequency to be largely independent dimensions. The finding that the functions are not identical provides some evidence to support a weak luminance spatial frequency selectivity in stereoscopic channels tuned to corrugation frequency.

Depth Perception↗
PubMed1997

High definition 3D ultrasound imaging.

We have demonstrated high definition and improved resolution using a novel scanning system integrated with a commercial ultrasound machine. The result is a volumetric 3D ultrasound data set that can be visualized using standard techniques. Unlike other 3D ultrasound images, image quality is improved from standard 2D data. Image definition and bandwidth is improved using patent pending techniques. The system can be used to image patients or wounded soldiers for general imaging of anatomy such as abdominal organs, extremities, and the neck. Although the risks associated with x-ray carcinogenesis are relatively low at diagnostic dose levels, concerns remain for individuals in high risk categories. In addition, cost and portability of CT and MRI machines can be prohibitive. In comparison, ultrasound can provide portable, low-cost, non-ionizing imaging. Previous clinical trials comparing ultrasound to CT were used to demonstrate qualitative and quantitative improvements of ultrasound using the Sandia technologies. Transverse leg images demonstrated much higher clarity and lower noise than is seen in traditional ultrasound images. An x-ray CT scan was provided of the same cross-section for comparison. The results of our most recent trials demonstrate the advantages of 3D ultrasound and motion compensation compared with 2D ultrasound. Metal objects can also be observed within the anatomy.

Computer Simulation↗
PubMed1997

Beginning in research.

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Health Knowledge, Attitudes, Practice↗
PubMed1997

Spectrum of spontaneous mutations in liver tissue of lacI transgenic mice.

The advent of transgenic technology has greatly facilitated the study of mutation in animals in vivo. The Big Blue mouse system, transgenic for the lacI gene, permits not only the quantification of mutations in different tissues but also provides for the generation of in vivo-derived mutational spectra. This report details the sequence alterations of 348 spontaneous mutations recovered from the liver of 6-8-week-old male Big Blue mice. The spectra recovered from two strains of mice, C57BI/6 and B6C3F1, were compared and found to be very similar. The predominant mutations are G:C-->A:T transitions, with 75% of these occurring at 5'-CpG-3' sequences. This mutational bias is consistent with deamination-directed mutation at methylated cytosine bases. The second most common class of mutations is G:C-->T:A transversions. A significant clonal expansion of mutants was found in several animals, and this was used to make an approximate correction of the mutant frequency such that the most conservative estimate of mutation frequency is presented. The establishment of this substantial database of spontaneous mutations in the liver of Big Blue mice is intended to serve as a reference against which mutations recovered after treatment can be compared.

Animals↗
PubMed1997

Credentialing study. An AAOHN report.

This article is third in a series of three articles addressing credentialing to appear in AAOHN Journal. The first article, "Credentialing: Concerns and Issues Affecting Occupational Health Nursing," by Olson, Verrall, and Lundvall, appeared in the May 1997 issue [45(5):231-238]. The second article, "Certification and Occupational Health Nursing: An Historical Perspective," by Verrall appeared in the June 1997 issue [45(6):283-289].

Credentialing↗
PubMed1997

Writing abstracts.

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Abstracting and Indexing↗
PubMed1996

Neurodevelopmental presentation of dysphagia.

Successful oral feeding and growth of infants and children are dependent not only on functional deglutition, but also on a broad range of neurodevelopmental skills involving sensory systems, cognition/communication, and gross and fine motor behaviors. Children with neurogenic dysphagia often have a broad spectrum of neurodevelopmental impairments that affect these streams of development. Speech/language pathologists, as members of interdisciplinary teams, can provide unique contributions to the early diagnosis and management of neurogenic dysphagia in childhood.

Brain↗