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Biomedical subjects

B Robins

Publications and source records attributed to B Robins.

At least 19 recordsLinked to original sources
PubMed2001

Caudal epidural blood patch for treating intractable vomiting in a child after placement of a permanent intrathecal catheter.

Postdural puncture cerebral spinal fluid (CSF) leak most often manifests as a postdural puncture headache (PDPH). The reported frequency in young children varies (1-4). Persistent CSF leak may also be present without PDPH. We present a case of postoperative nausea and vomiting resulting from a presumed lumbar CSF leak in a nonverbal child after surgical placement of a permanent intrathecal catheter. Treatment with an epidural blood patch (EBP) via the caudal approach resulted in complete relief of symptoms.

Baclofen↗
PubMed2001

Anesthetic management of acquired tracheoesophageal fistula: a brief report.

IMPLICATIONS: Tracheoesophageal fistula may be either a congenital lesion or an acquired condition, most often resulting from foreign body ingestion. Location of the lesion has implications for anesthetic management and single lung ventilation may be required to facilitate surgical repair. In pediatric patients, intentional mainstem intubation may be required.

Anesthesia, Inhalation↗
PubMed2001

Participation of racial/ethnic groups in clinical trials and race-related labeling: a review of new molecular entities approved 1995-1999.

Few recent data are available from formal evaluations of approved new drug applications to address perceptions that racial and ethnic groups are under-represented in clinical trials of new drugs. This study reviews racial and ethnic group participation in clinical trials and race-related labeling for new molecular entities approved during a five-year period by the Food and Drug Administration's (FDA) Center for Drug Evaluation and Research (CDER). This was a retrospective review of FDA medical officers' reviews of clinical trial protocols and product labeling for 185 new molecular entities (NME's) approved by CDER between January 1,1995, and December 31, 1999. Enrollment data were obtained from the reviews and tabulated according to race/ethnicity. The approved product labeling was searched for statements related to product testing in various racial/ethnic groups. All data were compiled and analyzed using Microsoft Access. This study quantifies the participation of racial/ethnic groups in clinical trials by year and therapeutic category. Additionally, the study categorizes labeling based on the types of effects described as related to race/ethnicity. Racial and ethnic groups appear to participate in clinical trials to varying degrees. African Americans participated in trials to the greatest extent; however, their participation steadily declined from 12% in 1995 to 6% in 1999. Among trials known to be conducted only in the U.S., African-American participation is comparable to their representation in the U.S. population. In all cases, participants designated as Hispanic appear to be far below their representation in the population. Some differences in participation for all racial and ethnic groups are seen when comparisons from year-to-year or among drug classes are made. Labeling for 45% (84/185) of the products contained some statement about race, although in only 8% (15/185) were differences related to race described. Fifty percent (50%) of the effects were pharmacokinetic, 39% were efficacy, and 11% were safety. One product label recommended a change in dosage based on racial differences.

Clinical Trials as Topic↗
PubMed2000

Re-Os isotopic evidence for a lower crustal origin of massif-type anorthosites

Massif-type anorthosites are large igneous complexes of Proterozoic age. They are almost monomineralic, representing vast accumulations of plagioclase with subordinate pyroxene or olivine and Fe-Ti oxides--the 930-Myr-old Rogaland anorthosite province in southwest Norway represents one of the youngest known expressions of such magmatism. The source of the magma and geodynamic setting of massif-type anorthosites remain long-standing controversies in Precambrian geology, with no consensus existing as to the nature of the parental magmas or whether these magmas primarily originate in the Earth's mantle or crust. At present, massif-type anorthosites are believed to have crystallized from either crustally contaminated mantle-derived melts that have fractionated olivine and pyroxenes at depth or primary aluminous gabbroic to jotunitic melts derived from the lower continental crust. Here we report rhenium and osmium isotopic data from the Rogaland anorthosite province that strongly support a lower crustal source for the parental magmas. There is no evidence of significantly older crust in southwest Scandinavia and models invoking crustal contamination of mantle-derived magmas fail to account for the isotopic data from the Rogaland province. Initial osmium and neodymium isotopic values testify to the melting of mafic source rocks in the lower crust with an age of 1,400-1,550 Myr.

Journal Article↗
PubMed2000

Smaller-than-expected sevoflurane concentrations using the Sevotec 5 vaporizer at low fill states and high fresh gas flows.

Smaller-than-expected concentrations of sevoflurane were delivered by Sevotec 5 vaporizers (Datex-Ohmeda, Madison, WI) at low-fill states, 8% dialed concentrations, and high fresh gas flows. Clinically, this would lead to prolonged induction times. The risk of complications from prolonged inhaled induction could be increased when using a vaporizer with these characteristics.

Anesthesia, Inhalation↗
PubMed2000

Sticker sedation.

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Child Behavior↗
PubMed1999

Choosing a malpractice insurance carrier. What you should know!

It's one of your most important decisions, because the insurance company you choose protects your financial assets and your good name. From financial strength to an aggressive defense, here's what you should know about selecting a professional liability insurance company.

Humans↗
PubMed1994

Diabetes mellitus: a frequent factor in liability claims.

Inappropriate treatment of diabetes mellitus is the cause of an increasing number of malpractice claims. The authors present pertinent trends elicited by an analysis of diabetes claim files and their possible prevention. Files from February 1, 1977, to February 1, 1992, were reviewed.

Adult↗
PubMed1992

Difficulty in extubation. A cause for concern.

Difficulties in removing the tracheal tube from the trachea are relatively uncommon. We report here a case of difficult extubation which was precipitated by pulling off the pilot balloon and valve assembly in order to deflate the cuff.

Adult↗
PubMed1985

Bombyx mori 28S ribosomal genes contain insertion elements similar to the Type I and II elements of Drosophila melanogaster.

We have examined the 28S ribosomal genes of the silkmoth, Bombyx mori, for the presence of insertion sequences. Two types of insertion sequences were found, each approximately 5 kb in length, which do not share sequence homology. Comparison of the nucleotide sequences of the junction regions with the uninserted gene reveals that one type of insertion has resulted in a 14 bp duplication of the 28S coding region at the insertion site. The location of this insertion and the 14 bp duplication are identical to that found in the Type I ribosomal insertion element of Drosophila melanogaster. The second type of insertion element is located at a site corresponding to approximately 75 bp upstream of the first type. The location of this insertion, the variability detected at its 5' junction, and a short region of sequence homology at its 3' junction suggest that it is related to the Type II element of D. melanogaster. This is the first example of a Type II-like rDNA insertion outside of sibling species of D. melanogaster, and the first example of a Type I-like rDNA insertion outside of the higher Diptera.

Animals↗
PubMed1971

Handicapped children.

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Persons with Disabilities↗