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Biomedical subjects

B Riedel

Publications and source records attributed to B Riedel.

At least 55 records · Page 3Linked to original sources
PubMed1976

Investigations of urinary stone formation following persorption.

Persorption is the excretion in urine of particles that have been absorbed (persorbed) from the gastrointestinal tract. In experiments with rats the effect of Herbst was combined with the production of renal calcium oxalate sediments by the oral administration of ethylene glycol and acidification with ammonium chloride. We used this method to investigate whether persorbed corpuscula may represent nuclei of crystallization in the formation of renal calculi. Lead sulfide, zirconium silicate and 45Ca-labeled calcium oxalate crystals were used as persorbable model bodies. It became apparent that orally supplied lead sulfide and zirconium silicate crystals could be found in the urine and the kidneys but they did not function as crystallization centers in the calcium oxalate sediments. However, radioactive labeled calcium could be demonstrated histoautoradiographically within the renal concrements. Our experiments showed that persorbed calcium oxalate crystals can work as nuclei for stone formation.

Ammonium Chloride↗
PubMed1975

Replacement of urinary bladder wall in the cat by autologous x-ray treated full thickness skin graft.

A partial urinary bladder resection was performed in 25 female cats. The defect was replaced with an X-ray treated autologous full thickness skin graft. This graft was shown to be an appropriate foundation for the rapid regeneration of transitional cell epithelium which was proven to be present after 4 weeks. Smooth muscle fibres were present in all cases after 12 weeks. Postoperatively, bladder capacity was adequate without evidence of incrustation or ossification. No changes were seen in the upper urinary tract. Compared to other types of autologous bladder wall replacement this method is simple and warrants clinical investigation.

Animals↗
PubMed1975

[Cytological examination for determining the therapeutic response of prostatic carcinoma to hormonal therapy (author's transl)].

51 patients with proven prostatic carcinoma stage B-D underwent control aspiration biopsy after hormonal therapy using the Franzén needle. The malignancies were classified into three grades and the cytological findings were compared with the malignancy grade of the tumor and the clinical course. At the same time the caryopycnotic index, as determined by swabs from the urethral fossa navicularis was measured in order to determine the serum estrogen level. As the result of the anti-androgenic therapy one finds degenerative changes in the tumor cells. The results showed that the poorer the histological differentiation of the tumor, the lesser was the cytological change. Only 6 of 34 patients with a good hormonal effect showed a progression of the tumor, whereas 16 of 17 patients with a poor hormonal effect showed clinical progression. 70% of the cases demonstrated agreement between the clinical course and the caryopycnotic index. No correlation was found between the caryopycnotic index and the histological grade of the tumor.

Adenocarcinoma↗
PubMed1975

[First experiences with the incontinence operation Kaufman III (implantation of a silicongel prothesis covered with polyurethanfoam) (author's transl)].

For operative treatment of urinary incontinence after TUR of the prostate, radical prostatectomy and meningocele operation the silicongel prothesis described by Kaufman was implanted. By compression of the bulbus urethrae a sealing effect was achieved. The pressure of the detrusor opens the urethra enough to enable urination. Seven patients were operated. The results directly after the operations were: three very good, two good and two bad. We achieved very good results by implantation of the prothesis "large" -in the case of the two bad operative results we used the "medium" size prothesis. By filling these protheses with 5 ml liquid they proved to be leaky. One of these was operatively removed and replaced by the size "large". This patient later developed a urethra stricture in the implantation region with overflow bladder after having been continent. By internal urethrotomy this condition was restored; except for minor dripping after miction the patient was continent. The prothesis of a direct postoperative continent patient had to be filled. This led to and infection with the development of fistula. The prothesis had to be removed. A further patient who sat on a hard object developed a lesion of the prothesis with resulting incontinence. At least six months after the operations four patients remained continent and three incontinent.

Aged↗
PubMed1975

Experimental urinary stone formation following persorption.

The 'effect of Herbst' was combined with the production of renal calcium oxalate sediments by oral administration of ethyleneglycol and acidification with NH4Cl. This investigation was made to see whether persorbed bodies may form nuclei in crystallization in the genesis of stone. Lead sulphide crystals and 45Ca-labelled calcium oxalate crystals were used as persorbable model bodies. It became apparent that lead sulphide crystals given by mouth could be found both in the urine and kidneys, but these did not form nuclei in calcium oxalate sediments. Radioactive-labelled calcium, however, could be proved histoautoradiographically within the renal concretions. Our experiments showed that persorbed calcium oxalate crystals can represent nuclei for stone formation.

Ammonium Chloride↗
PubMed1975

[Preoperative radiotherapy of bladder cancer].

Based on the observation of 58 patients with carcinoma of the bladder the effect of preoperative irradiation is reported. After application of 3500 Rad in about four weeks the examination of the surgery preparations revealed histological absence of tumor cells in one third of the cases approximately. The irradiation technique used is described and also the effects and side-effects of synchronization induced by 5-fluorouracil in a part of the group. Consequences for the therapeutic proceeding with regard to the carcinoma of the bladder are discussed.

Bone Marrow Diseases↗