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Biomedical subjects

B Richter

Publications and source records attributed to B Richter.

At least 109 records · Page 6Linked to original sources
PubMed1991

Evaluation of a structured treatment and teaching programme on asthma.

The objective of this study was to evaluate a structured treatment and teaching programme for adult patients with moderate to severe asthma. The design consisted of a prospective, before-after trial: the same consecutive patients were studied before and after intervention with observation periods 1 year before and 1 year after intervention. The investigation took place within a tertiary care centre (university hospital). A total of 142 consecutive patients were referred for in-patient treatment of their asthma, of whom 132 (93%) patients participated in the follow-up examination. The intervention consisted of a structured 5-d in-patient treatment and teaching programme presented by a specialized nurse educator. The aim of the programme was for the patient to assume greater responsibility for disease management, including self-monitoring of peak expiratory flow and qualified self-adaptation of drug therapy. The main outcome measures were the frequency of severe asthma attacks, hospitalization, and absenteeism from work (data provided by health insurance companies), patients' compliance and management skills. During the year before and the year after the intervention 71% and 36%, respectively of patients had one or more severe asthma attacks (mean difference 35%, 95% CI: 25-45%, P less than 0.0001). The percentage of patients who were hospitalized because of asthma decreased from 39% to 22% (mean difference 17%, 95% CI: 7-27%, P less than 0.002). The percentage of employed patients (n = 67) who were absent from work because of asthma decreased from 60% to 43% (mean difference 17%, 95% CI: 4-30%, P less than 0.04). The patients' adherence to maintenance drug therapy and their management skills improved significantly. It was concluded that the participation of patients with moderate to severe asthma in a structured treatment and teaching programme resulted in a substantial reduction in asthma morbidity in the year following the intervention.

Absenteeism↗
PubMed1991

[Surgical therapy and prognosis of vulvar carcinoma].

From 1954 to 1985 211 woman with carcinoma of the vulva were treated at the medical college Dresden. 66 patients were found at the FIGO stage I, 69 at stage II, 50 at stage III, 18 at stage IV; 8 could not be classified. In the total group of woman the cumulative survival rate due to the different stages were: 72% at stage I, 56% at stage II, 28% at stage III and 13% at stage IV. The 5-year survival rates were different in women undergoing a total vulva operation (76%) from vulvectomized women (60%) and partial vulvectomized woman (48%). So the total vulva operation had a great effect on outcome. In female patients which underwent palliative surgical treatment the survival rate could be increased by means of the postoperative radiation therapy. It is a matter of outstanding importance to the vulva carcinoma prognosis to operate radically and as soon as possible.

Adult↗
PubMed1990

[Are anti-thyroid drugs and iodine preparations for surgical preparation in Basedow's disease still current today?].

From 1979 to 1989, in 1938 hyperthyroid patients with different preoperative treatment, thyreotoxic crisis did no longer occur. In a prospective study, 28 patients with graves' disease were operated in severe hyperthyroidism (max. fT3 37.3 pmol/l, normal range 4.0-9.0; max. fT4 12.6 ng/dl, normal range 0.7-1.9) premedicated only by betablockers: the man of fT3 sank significantly within 1 hour after operation and returned to normal range after 8 hours. The fT4 sank significantly within the 1st postop. day and reached its normal value on the 4th postop. day. No rise of fT3 or fT4 was ever observed, nor was there any clinical sign of thyreotoxicosis. Therefore in hyperthyroidism, a routine preoperative treatment with antithyroid drugs or iodine is not necessary.

Adrenergic beta-Antagonists↗
PubMed1990

[Detection of IgG antibodies against rubella virus using the "Rubella-IgG-EIA SSW" test kit].

A new commercial ELISA test kit "Rubella-IgG-EIA SSW" is described for the determination of IgG antibodies to rubella virus. A panel of 99 sera was tested by "Rubella-IgG-EIA SSW" and by hemagglutination-inhibition (HI test). The results of enzyme-immunoassay (EIA) and of HI test correlate well; the coefficient of correlation is 0.95, the specificity is 90.9% and the sensitivity is 100%. A coefficient of correlation was found out of 0.92 between EIA and HI test in the evaluation of the quantitative procedure. The test kit can be used for determination of immune status to rubella virus and for quantitative detection of rubella-IgG antibodies.

Enzyme-Linked Immunosorbent Assay↗
PubMed1989

[Complications of temporary transvenous endocardial pacemaker therapy].

The prospective analysis of the results of the temporary transvenous-endocardial pacemaker therapy in 591 cases of treatment resulted in a total rate of complications of 37.1%. Hereby the main part of complications were disturbances of the function of electrodes (28.3%). The greatest numbers of complications showed infiltrable electrode catheters which were applied at bedside with a dislocation rate of 17.2% and a rate of not achieved stable stimulation positions of 13.7%. The smallest numbers of complications were to be observed in semiflexible stimulation catheters, which were positioned under X-ray control (dislocations in 4.1%, no achievement of a stable stimulation position in 3.3%). For the practice of the temporary pacemaker therapy from this analysis result particularly consequences in the choice of a suitable stimulation catheter and the methodical approach in positioning of this catheter.

Adams-Stokes Syndrome↗
PubMed1989

[Comparison between oral nutrition and enteral nutrition using a percutaneous endoscopically guided gastrostomy (PEG) in patients undergoing radiotherapy for head and neck tumors].

The nutritional state of 99 patients with tumors in the head and neck area was determined prior to, during and after radiotherapy by anthropometric, laboratory-chemical and immunological parameters. In 73 orally nourished patients, the nutritional parameters deteriorated very quickly during radiotherapy and recovered slowly and incompletely after radiotherapy. In 26 patients treated prospectively by percutaneous endoscopically guided gastrostomy (PEG), however, an improved nutritional state was achieved already during the irradiation in spite of a less favorable starting point. The subjective feeling of patients was questioned by means of the "quality of life" index according to Padilla et al. (1983). The preliminary results show an identical deterioration of the subjective feeling in both groups, but - as opposed to the other patients - force and working capacity did not decrease during radiotherapy in the enterally nourished patients. This corresponds to the objective nutritional parameters. However, an improvement of the subjective feeling after the end of radiotherapy was observed only in the orally nourished patients. Possible reasons are discussed. We have the opinion that an early and constant enteral nutrition by PEG can stabilize the nutritional state of patients with tumors in the head and neck area. Therefore we recommend to establish a prophylactic, pretherapeutic PEG if an aggressive multimodal therapy is planned, especially in case of apparent primary malnutrition.

Body Mass Index↗