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Biomedical subjects

B Richling

Publications and source records attributed to B Richling.

49 records · Page 3Linked to original sources
PubMed1982

Homologous controlled-viscosity fibrin for endovascular embolization. Part I. Experimental development of the medium.

The author used a two-component adhesive (homologous fibrinogen and thrombin) to develop a medium with controllable rate and extent of setting and coagulation. After mixing with the radiopaque substance metrizamide, the material meets the criteria postulated for an endoarterial embolization medium: variable and controllable viscosity, elasticity after setting, absence of toxicity, radio-opacity, and adequate sterilizability. After setting, the fibrin medium is a clear, solid, but soft elastic substance clearly visible on the X-ray film even in fine structures.

Arteriovenous Fistula↗
PubMed1982

Homologous controlled-viscosity fibrin for endovascular embolization. Part II: catheterization technique, animal experiments.

Part I of the present paper described the development of a substance for endovascular embolization from homologous fibrinogen, aprotinin, thrombin, metrizamide and CaCl2. Part II deals with the applicability of a controlled-viscosity fibrin mixture via different types of arterial catheters. In a flow-dynamic model the embolizing medium injected via a double syringe was shown to block a blood flow corresponding approximately to the flow encountered in cerebral angioma vessels. In the course of animal experiments the embolization of mesenteric arteries of rabbits showed the distribution of the embolizing medium to be dependent on its viscosity; the action of an embolizing medium applied by means of a double syringe was studied in the femoral arteries of rabbits. Scintigraphy was used to study the distribution of the substance in the body of the experimental animal after intravenous (i.v.) application; long-term studies of embolized auricular arteries in rabbits revealed parchment-like necroses after 5 to 10 days and the presence of radiopaque substances in the ear stumps after 6 weeks.

Animals↗
PubMed1982

Problems of long-term cannulation of cisterna magna and subarachnoid space in the conscious dog.--Technical note--.

Studies on the influence of substances on the central nervous system and on the function of the blood-CSF-barrier made long-term cannulation of the CSF compartment interesting. This study was to test, whether a permanent CSF-drainage from any point of the subarachnoid space was possible with modified "tissue cages" (Guyton 1963). For that purpose a steel wire cage and a teflon cage were implanted subarachnoidally into beagle dogs. The two cages stopped draining on the second and on the third day respectively. Histological examination showed, that, because of the strong reaction of animal tissue to implanted material, direct cannulation of the CSF compartment does not seem feasible. In the second part the "Manuilov-system" was modified. An indwelling guiding tube was implanted and fixed with a horseshoe shaped plate to the occipital bone. Puncture can be made on the awake dog without local anaesthetic and produces samples of 1.5 to 2.0 ml CSF for up to 30 days without complications.

Animals↗
PubMed1980

[Electronic manipulation of clinical data in the hospital].

In contrast to the applications in everyday life computers have found only little acceptance hitherto in medical field. At the department of neurosurgery of the Landesnervenklinik Salzburg an input-terminal was installed and connected with its computing centre. The examining physician feeds the data obtained from the first physical examination with the typewriter keyboard of the input-terminal using an alphabetical and numerical key. The total findings are typed by the computer grammatically correct. The electronic storage of these data allows quick access to single findings and also an easy statistical evaluation.

Computers↗
PubMed1980

Predicting lethal outcome after severe head injury -- a computer-assisted analysis of neurological symptoms and laboratory values.

A total number of 58 parameters (laboratory values, neurological symptoms, and vegetative parameters) were evaluated in 150 patients during the first seven days after severe head injury. The patients were divided into two groups, "survivors" and "non-survivors". Eight easily evaluable routine parameters with the most significant differences between the two groups of patients were used for statistical evaluation of a "no survival chance score". These highly indicative parameters are serum osmolarity and urea, blood glucose, total bilirubin, motor reaction to stimuli, body temperature, respiratory activity, and pupil reaction. A "low survival chance limit" was evaluated from each of these parameters by computer analysis. None of the patients in the series survived when three or more of these eight parameters had climbed beyond the limit. So far, the system is able to predict "no survival chances" in 50.8% of the non-survivors some six days prior to death; 80% of these predictions could be made by the fourth day after injury.

Adolescent↗
PubMed1979

Endothelial lesions after temporary clipping. A comparative study.

The effect of temporary clipping on the arterial endothelium of rats was examined with scanning electron microscopy. The opening pressure of four Heifetz clips was modified by changing the springs. Four different clip forces (20, 35, 45, and 65 gm), four periods of clipping (10, 30, 60, and 180 minutes), and three vessel diameters (smaller than 1 mm, 1.1 to 1.3 mm, and 1.4 to 2 mm) were compared. Different grades of endothelial damage were observed. On gross examination the damage involved a detachment of endothelium and the adherence of platelets to the subendothelial tissue. The duration of clipping seemed to be of more importance than the clip force, whereas the vessel diameter had no recognizable influence.

Animals↗
PubMedDate not supplied

[Incidence of recurrence of aneurysmal bone cysts following surgical treatment and adjuvant therapy with phenol].

Between 1966 and 1991, at the Department of Orthopaedics 34 patients with a mean age of 15.7 years (range 7-46 years) underwent surgery because of aneurysmatic bone cysts. Mean follow-up was 11 years (range 1-26.3 years). We observed a total rate of recurrence of 11.8%. In a group of 9 patients who received local phenol therapy after curettage and bone transplantation no recurrence was observed. The different surgical and conservative methods of treatment are discussed also with respect to rates of recurrence stated in the literature.

Adolescent↗