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B Reimann

Publications and source records attributed to B Reimann.

At least 19 recordsLinked to original sources
PubMed1992

[Use of pronouns: formal and functional aspects in the early phases of language development].

This article presents findings from empirical studies of the development of the use of pronouns in early child language. This presentation includes discussion of 1) when personal, reflexive, possessive, and indefinite pronominal forms appear in child-initiated contexts, 2) which errors emerge, and 3) which communicative functions utterances with pronouns have in dialogue. A first comparison of German-speaking and (American-)English-speaking children's usage is offered, focussing in particular on the use of the pronominal forms I/ich, you/du, and my/mein. This crosslinguistic comparison reveals differences in the age of first use, but simultaneously suggests similarities in functional characteristics of such usage. The findings are discussed in connection with the question of the development of children's communicative competence.

Child, Preschool↗
PubMed1991

[Syntagmatically oriented reactions in the early phases of speech development].

Within a longitudinal observational study of two children aged from 18 to 36 months spontaneous reactive utterances were analysed. It could be found syntagmatic reactions without topic coherence with the utterances of the previous speaker. The specialty of these utterances consists in the fact that the child, after having perceived certain words in the parental utterances, creates an association to the previously heard grammatical context. The results are discussed within the scope of problems of language acquisition in children.

Child, Preschool↗
PubMed1991

[Low-dose fish oil in primary hypertriglyceridemia. A randomized placebo-controlled study].

In a double-blind, randomized, placebo-controlled trial, we prospectively investigated the effects of two low doses of fish oil (10.5 and 5.25 g daily) in capsule form in patients with primary hypertriglyceridemia. During a 6 weeks' therapy with 10.5 g fish oil, serum triglycerides decreased by a mean of 38% from 578 +/- 167 to 358 +/- 66 mg/dl (p less than 0.05). With 5.25 g daily, triglyceride levels fell by 20% from 538 +/- 100 to 431 +/- 64 mg/dl (n.s.). With placebo, triglycerides increased by 8% from 835 +/- 176 to 900 +/- 228 mg/dl (n.s.). Total and HLD-cholesterol levels remained uninfluenced in all groups. Serum alkaline phosphatase decreased by a mean of 12% from 86 +/- 7 to 76 +/- 6 units/l in the patients treated with 10.5 g fish oil (p less than 0.01). Platelet aggregation after induction with collagen was slightly, but significantly inhibited in the patients treated with the higher dose of fish oil. Thus, in patients with primary hypertriglyceridemia, fish oil at a daily dose of 10.5, but not at 5.25 g, led to a significant reduction of serum triglyceride levels and to an inhibition of platelet aggregation.

Cholesterol↗
PubMed1990

Effect of diamide on polyphosphoinositide metabolism in red blood cells.

In intact red cells diamide had no strong influence on monoester phosphate group turnover of phosphatidylinositol 4,5-bisphosphate (PIP2), phosphatidylinositol 4-phosphate (PIP) and phosphatidic acid (PA) due to the potent GSH protection of these pathways in vivo. Following the complete GSH oxidation diamide impaired the turnover of PIP and PA dramatically. However that of PIP2 did not show any change. Indeed, a drastic irreversible decrease of PIP- and PA turnover was caused by a mild oxidative stress with diamide in G6PD deficient red cells.

Azo Compounds↗
PubMed1990

Metabolism of phosphatidylinositides in rabbit red blood cells.

The particularly strong maturational loss of the monoester phosphate group turnover in PIP2 was demonstrated by in vivo as well as in vitro studies with rabbit reticulocytes. Both cycles of the phosphatidylinositide metabolism (PPI) were relatively insensitive against oxidative stress. Surprisingly, at high concentrations diamide did not alter the PIP2-, indeed, the PIP-turnover was drastically decreased.

Adenosine Triphosphate↗
PubMed1989

A reappraisal of the binding of cytosolic enzymes to erythrocyte membranes.

Several cytosolic proteins have been shown to be associated with hypotonic erythrocyte ghosts via electrostatic interactions with the anion transport band 3 protein. This article considers the problems of demonstrating binding under physiological conditions and reviews the evidence for the relevance of enzyme binding to the membrane for the regulation of glycolysis. The hypotheses for the existence of topological and sequential multienzyme complexes of the glycolytic enzymes in erythrocytes are also discussed.

Cytosol↗
PubMed1989

[Possibilities and limits of therapy of injuries of the cervical vertebrae with halo fixation].

74 patients were treated with a Halo-thoracic brace in the Department of Traumatology of the AK St. Georg between 1980 and 1986. Of these, 61 had fractures of the cervical spine, nine had tumor-osteolysis, and four had inflammatory destructions of the vertebrae. In almost all cases of fractures of the upper cervical spine (C0-C2) bone healing occurred with applying the Halo fixation alone. In the middle and lower cervical spine, however, secondary operative measures were often necessary because of persistent instabilities, redislocations or neurologic disturbances. New experience in the palliative treatment of malignant osteolysis of the cervical spine shows, that restabilisation of the segments concerned can be achieved by the combined use the Halo apparatus, surgical resection of the involved vertebral bodies with bone grafting and radiotherapy. A new radiolucent Halo apparatus broadens diagnostic and therapeutic facilities.

Adult↗
PubMed1989

[Perforation of gastroduodenal ulcer. Risk factors and choice of procedure].

The well known surgical risk factors, such as age, time of perforation as well as size and localisation of necrosis, were confirmed in retrospective and prospective analyses of perforation of gastroduodenal ulcers (n = 504). Incidence was unchanged in the two different time-related groups, with 3.2 or 3.7 cases in one month. There was a clear-cut need for excision of the ulcer or necrotic margin. Perforation was attributable to malignant tumours in 2.1 per cent of the cases. The authors have definitely adopted the concept of earlier primary surgery (23 per cent of all cases, as compared to 10.4 per cent before). The risk associated to it was found to be lower than linked to palliative operations. The lethality rate was as low as 7.6 per cent, once due consideration was given to the above risk factors for adequate choice of surgical methods. Particular attention was given to ulcer localisation and clinical course. Hence, lethality has clearly dropped below earlier data.

Adult↗
PubMed1987

Maturation dependence of the turnover of phosphatidylinositides in rabbit red blood cells.

"Pulse-chase" experiments with erythrocytes and reticulocytes prelabelled with 32P-Pi revealed a high turnover of the monoester phosphate groups of PIP2 in reticulocytes, which declines strongly during maturation [Maretzki et al., Biomed. Biochim. Acta 45, 1227-1236 (1986)]. The 3H-inositol uptake exhibits a strong maturational loss. A carrier-mediated uptake of inositol in reticulocytes is suggested. In reticulocytes PI, PIP and PIP2 incorporated 3H-inositol in the relative distribution of 86; 5 and 9%, respectively, but only PI to a minor extent in erythrocytes. A small release of 3H-labelled inositol phosphates was found in reticulocytes, which was not stimulated by extracellular calcium during incubation. Determination of the 32P/3H-ratio in double-labelled phosphatidylinositides in reticulocytes demonstrated a very slow turnover of the diester phosphate bonds compared with that of the inositol phosphate ester groups.

Animals↗
PubMed1986

Maturation of rabbit reticulocytes: strong decline of the turnover of polyphosphoinositides.

The [32P]phosphate labelling of ATP and polyphosphoinositides (PI) of intact rabbit reticulocytes and mature erythrocytes was compared. Despite the fact that reticulocytes have a 30-fold higher turnover of ATP than mature erythrocytes, the 32P-labelling of the cellular ATP pool was identical. The 32P-Pi entry into the cells is the rate-limiting step for 32P-phosphate isotopic equilibration of the ATP-pool and is independent of maturation. The rates of 32P-phosphate incorporation into PI-4,5-P2 and into PI-4-P, respectively, were 17-fold and 8-fold higher in reticulocyte-rich cell suspensions than in erythrocytes. The specific radioactivity of PI-4,5-P2 labelling reaches 55% and that of PI-4-P 40% of the ATP specific activity. However, a rapid isotopic equilibration of the polyphosphoinositides, was found. These findings indicate the existence of a heterogeneity of polyphosphoinositide pools. Reticulocyte membranes lose about 30% of their polyphosphoinositides during maturation proportional to the total loss of phospholipids.

Adenosine Triphosphate↗
PubMed1979

Early molecular events in the interaction of enveloped viruses with cells. I. A fluorescence and radioactivity study.

The fluorescence depolarization of 1,6-diphenyl-hexatriene was used to study the dynamic properties of the hydrophobic regions of the lipid envelopes of ortho- and paramyxoviruses as well as of the Rous sarcoma virus and of the membrane lipids of susceptible and nonsusceptible cells. The systems investigated where active and inactive influenza viruses, and NDV virus acting on chick embryo fibroblasts and Rous sarcoma virus acting on susceptible (C/E) and nonsusceptible (C/B) chicken-cell. Polarization degrees and mean rotational correlation times of DPH embedded in viral lipids were significantly higher than those of DPH in the cell membranes, due to a higher rigidity of the virus envelopes. When suspensions of labelled viruses and unlabelled cells or unlabelled viruses and labelled cells were mixed, a characteristic change of the fluorescence polarization degrees with time was observed. This behaviour was ascribed to label transfer from virus to cell membranes or vice versa. While the rate constants of label transfer from virus to cells and cells to virus were about the same for the penetrating viruses the rate constants of label release from inactive virus to cells were much larger than for the migration in the opposite direction.

Animals↗
PubMed1979

Early molecular events during the interaction of enveloped riboviruses with cells. II. A kinetic study.

A kinetic model was constructed and partly solved to describe the migration of the fluorescence label 1,6-diphenylhexatriene (DPH) in both directions when enveloped viruses, labelled with DPH in their envelopes are in contact with unlabelled cells or cell labelled in their membranes are in contact with unlabelled enveloped viruses. The central assumption is that two types of receptor sites exist on the cell surface, i.e., physical adsorption sites (P-sites), available to all the viruses studied in these papers and binding sites (B-sites) available only to the viruses which penetrate into the specific cells. The differential equations for the label migration, for different values of the ratio number of viruses number of sites were numerically solved, assuming different fractions of P- and B-sites. The equations also describe, appropriately the mechanism of rapid label migration in the system and substantiate the magnitude "time of residence" of the nonpenetrating viruses adsorbed on the cell surface. The resulting curves match satisfactorily those for the label release by the viruses and account well for the steady state values of the kinetics of label migration in the virus-cell system.

Adsorption↗
PubMed1975

[Control intensity of glycolytic enzymes in ultrasonic hemolysates of erythrocytes].

By addition of enzyme the control intensity was determined on the pacemaker enzymes hexokinase and phosphofructokinase, as well as on glyceraldehyde-3-phosphate-dehydrogenase and the pyruvate kinase with a control intensity of almost 0 in ultrasonic hemolysates from erythrocyte concentrate. This hemolysate approximately reflects the conditions existing in the intact cell with regard to glycolytic rate, ATP supply, and metabolite concentration. It is therefore suitable as a cell model, excluding the membrane, for studying inner control factors. For HK, PFK, GAPD, and PK predictions based on the linear glycolytic model about the significance of these enzymes for the regulation of the glycolytic rate could be confirmed.

Erythrocytes↗