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Biomedical subjects

B R Zimmerman

Publications and source records attributed to B R Zimmerman.

47 records · Page 3Linked to original sources

Prolonged follow-up in diabetic retinopathy treated by sectioning the pituitary stalk.

Because no complete long-term follow-up of visual status after pituitary ablation has been reported, records were reviewed on all 40 patients undergoing sectioning of the pituitary stalk for diabetic retinopathy at the Mayo Clinic from 1961 through 1968. One patient died and another was blind immediately postoperatively. One patient was lost to follow-up after 125 months. Twenty-seven patients have died after a follow-up interval of 7 to 120 months (mean, 63 months). The last available evaluation of these patients indicated stable or improved visual acuity in 20 patients. Eleven patients remain alive. Seven of these have stable or improved visual acuity and retinopathy. We conclude that although late post-operative mortality is high, in carefully selected patients with florid retinopathy but no fibrosis, pituitary ablation is an effective method for maintaining visual acuity.

Adolescent↗

Nuts and bolts.

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Diabetes Mellitus↗

Dyslipidemia and diabetes: a personal view.

Cardiovascular disease, the main cause of morbidity and mortality in patients with diabetes, justifies an aggressive approach to the reduction of modifiable risk factors. Lipid values are generally normal in patients with insulin-dependent diabetes mellitus, but hypertriglyceridemia and low levels of high-density lipoprotein (HDL) cholesterol are frequently associated with non-insulin-dependent diabetes mellitus (NIDDM). Recommendations for screening and treatment of patients without diabetes do not apply to those with NIDDM. Screening should be done annually and should include fasting total cholesterol, triglycerides, and HDL cholesterol. Therapeutic recommendations based solely on the low-density lipoprotein cholesterol level are inappropriate. Hypertriglyceridemia cannot be ignored in patients with NIDDM. Therapy should first be directed toward improved control of the diabetes through diet, exercise, and insulin or sulfonylureas. Therapeutic goals are selected on the basis of individual risk assessment and are strongly influenced by the presence of preexisting vascular disease. When the goals are not achieved through improved control of diabetes, lipid-lowering drug therapy, based on the specific profile of the lipid abnormalities, should be initiated.

Journal Article↗

Brittle diabetes.

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Diabetes Mellitus, Type 1↗