Veterans Administration procedures for handling cytotoxic agents.
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Antineoplastic Agents↗
Biomedical subjects
B R Harrison
Publications and source records attributed to B R Harrison.
Developing guidelines for working with antineoplastic drugs.
The potentially hazardous properties of antineoplastic drugs and problems associated with the admixture and administration of injectable antineoplastics are reviewed. The mutagenicity of anticancer drugs, carcinogenicity testing in animals, carcinogenicity of antineoplastic agents in humans, and federal regulation of carcinogens are discussed. Concern in the literature regarding the handling of antineoplastic drugs in reviewed briefly, and guidelines for proper handling are suggested. Local hospital guidelines on the handling of antineoplastic drug products should be designed to protect health-care workers from unnecessary exposure to potential carcinogens.
Antineoplastic Agents↗
Coombs'-positive hemolytic anemia and ibuprofen.
A patient who developed an autoimmune hemolytic anemia during treatment with ibuprofen (Motrin) is described. Positive indirect Coombs' reaction was demonstrated with the patient's red blood cell eluate in the presence of the drug, supporting a drug-related immune hemolysis. The positive direct Coombs' reaction to anti-C3 antiserum strongly suggested that the immune hemolysis in this patient is probably mediated through complement alone; however, the presence of a small amount of IgG antibodies on the surface of the red blood cells which cannot be detected under conventional screening procedures cannot be completely excluded. Further studies, both clinical and laboratory, disclosed that the responsible ingredient in this particular instance appeared to be the orange dye coating of the Motrin-400 tablet rather than the ibuprofen itself.
Aged↗
Early repair of vesicovaginal fistula.
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Aftercare↗