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Biomedical subjects

B R Allen

Publications and source records attributed to B R Allen.

At least 55 records · Page 3Linked to original sources
PubMed1983

The aetiology of psoriasis: clues provided by benoxaprofen.

Twenty-four patients with psoriasis completed a double-blind trial of benoxaprofen for their cutaneous lesions. Six out of thirteen on the active drug showed very marked improvement. It is believed that benoxaprofen acts by interfering with the migration of polymorphs into the skin through inhibition of leukotriene B4 synthesis.

Adult↗
PubMed1980

Insulin-induced lipoatrophy: evidence for an immune pathogenesis.

Skin biopsy samples from 14 diabetic patients with lipoatrophy at injection sites and from five insulin-treated diabetic patients without such lipoatrophy (controls) were examined by immunofluorescence for the deposition of immunological components. Also sera from 13 of the patients with lipoatrophy and from all of the controls were assayed for insulin-binding capacity. Biopsy samples from the edge of lipoatrophic areas (eight cases) invariably showed abnormal deposition of immunological components in dermal vessel walls, whereas no such deposition was seen in the control samples. Mean serum insulin-binding capacity was 33.1 microgram/l in the patients with lipoatrophy compared with only 4.6 microgram/l in the controls. These findings suggest that insulin-induced lipoatrophy results from the local formation of immune complexes, complement fixation, and release of inflammatory mediators from the cellular infiltrate.

Adolescent↗
PubMed1978

R.E.M. syndrome.

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Adult↗
PubMed1978

Ichthyosis hystrix.

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Child, Preschool↗