Search PubMed⌕ Search

Biomedical subjects

B Planchon

Publications and source records attributed to B Planchon.

87 records · Page 5Linked to original sources
PubMed1985

[Increased serum IgA levels in alcoholic polyneuropathy. Pathogenetic discussion].

Increased serum IgA in patients with direct toxic alcoholic peripheral neuropathy was studied prospectively in 33 patients with an obvious clinical polyneuropathy confirmed by electrophysiological investigations. The average concentration of IgA in this group (450 mg/100 ml) was significantly higher than in a group of 24 matched alcoholic control patients without peripheral neuropathy (306 mg/100 ml), p less than 0.0001. The authors discuss possible direct and indirect modifications of the humoral immune response due to the peripheral neuropathy.

Alcoholism↗
PubMed1983

[Alcoholic neuroacropathy. Recent diagnostic and pathogenic attainments].

The authors report the results of a prospective study of 28 patients with alcoholic neuroacropathy or the Bureau and Barrière syndrome. The investigations included biochemical analysis of the alcoholism, electrophysiological studies and, in 4 cases, electron microscopy of the musculocutaneous nerve biopsy. Bone scintigraphy with foot and hand scans was carried out in all cases for a more exact and above all, earlier diagnosis of the neurological osteoarthropathy. The clinical syndrome was attributed to a polyneuropathy with a large sensory component of the alcoholic "dying back" variety in all cases. High VGM levels associated with high serum IgA levels appears to be a biochemical diagnostic criteria of this condition. The latter parameter was not closely related to the hepatocytic status of the patient but suggests a direct or indirect effect of the neuropathy on humoral immunity. All cases had characteristic bone scans with high uptake at points of mechanical stress of the anterior part of the foot (first metatarsophalangeal joint). This finding, which is also observed in alcoholic sensory neuropathy without trophic disturbances prompts the authors to define a preacropathic state and an evolutive and pathogenic outline of the disease.

Alcoholism↗
PubMed1982

[Bureau-Barrière's acro-neuropathy. Complementary studies and definition of ante-acropathy status (author's transl)].

Systematic study of 28 patients suffering of Bureau-Barrière's acro-neuropathy. This study emphasize several particular factors. Significant increase of IgA, with a slight extend of transferrin. The authors debate the straight correction between increase of IgA and nervous illness. Study of peripheral nerves exhibits, in optic and electronic microscopies, direct and indirect signs of wallerian degeneration and significant axonal lesional prevalence. The study of anatomical specimen (foot) corroborates this data. Bony scintigraphic show the constancy of fixation and his connection with bearing surface. Witness demonstrate the specific character of this data. This investigations prove that the Bureau-Barrière's diseases is an alcoholic neuro-acropathy and allow the definition of ante-acropathic status (axonal sensitive neuropathy-scintigraphic fixations, increase of IgA). Prophylaxis in emphasized.

Extremities↗
PubMed1980

[Eczematoid dermo-epidermitis].

A methodic study of 50 cases, had to the discussion of a real clinical well established entity. The lesions start from an initial site, located on the inferior limbs in 2/3rd of the cases; then within a variable period of time extend larger and larger by proliferating in numerous patches. These lesions present as polymorphic, erythemato-squamous or oozing. They often evolve towards recurrence. The disease is more frequently encountered among 50-year-old men. Several factors contribute to the onset of the lesions: chronic alcoholism--lack of sanitary conditions--microbial background--stasis--overweight. A disturbed system of cutaneous protection and a lack of immune defences versus an antigen, probably a bacteria, are at the origin of the pathogenesis of these disorders. Considering the treatment, we wish to underline the benefit of local coal tar applications.

Adult↗
PubMedDate not supplied

Experimental venous thrombosis: what animal model?

A new experimental venous thrombosis model is described and its role relative to other models is defined. Previous models are not satisfactory for all types of investigation. Opposite, present model based on the three classic thrombogenic factors is suitable for venous scintigraphy and evaluation of different forms of therapy for venous thrombosis of the limbs. So this model permits research on diagnosis and therapy of thromboembolic disease.

Animals↗