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Biomedical subjects

B Pinto

Publications and source records attributed to B Pinto.

At least 37 records · Page 2Linked to original sources
PubMed1979

Different types of hypercalciuria in patients with renal lithiasis and evidence of the calcium renal waste.

A study of normal subjects and patients with hypercalciuria and recurrent renal stones has identified three main types of hypercalciuria: complex, absorptive and renal. Complex hypercalciuria is a combination of absorption, renal leak and resorption factors. Absorption and renal leak were examined by means of a 45Ca test. Resorption is defined as an increase of the urinary calcium:creatinine ratio while the subjects are being maintained on an intake of 400 mg of calcium per 24 h.

Calcium↗
PubMed1978

Diethylaminoethanol-cellulose in the treatment of absorptive hyperoxaluria.

There were 22 patients in whom oxalate stones formed and who had absorptive hyperoxaluria treated with diethylaminoethanol-cellulose. In more than 2 years this form of treatment did not seem to have any serious side effects. It achieved a decrease of urinary oxalate values in all patients in whom oxalate hyperabsorption had been found. Diethylaminoethanol-cellulose is an anionic exchanger capable of retaining oxalate in vitro and in vivo.

Absorption↗
PubMed1978

Oxalate transport by the human small intestine.

Oxalate was transported in vitro by intestinal brush border cells from rabbit and human by a non-energy-dependent diffusion mechanism. An oxalate-binding protein that had an approximate molecular weight of 73,000 was identified in the human intestine (ileum), was localized in the cytosol cell fraction, and was affected by calcium and magnesium, which increased the oxalate binding.

Animals↗
PubMed1977

Interaction of uricine with uric acid and its effect on uric acid precipitation.

Uricine is a yellow-red pigment isolated from uric acid stones where it is always found. It binds to the uric acid, as shown by gel chromatography, at constant uric acid elution. It also increases the capacity of the uric acid to form larger aggregates and therefore the capacity of the uric acid to precipitate is enhanced. The uric acid-uricine aggregates may be separated by high speed sucrose centrifugation gradients.

Binding Sites↗
PubMed1977

Urinary excretion of uricine.

The excretion of uricine or yellowish-red pigment from uric acid stones and its binding by uric acid seems to affect the precipitation of uric acid. Uricine was determined by ion exchange chromatography followed by measurement of the alkaline fluorescence emission. The uricine urinary excretion and the uricine-uric acid potential binding were determined in 11 control subjects, 20 recurrent uric acid stone formers, seven calcium stone formers with hyperuricuria, and five gouty patients without urinary stone formation. Uricine excretion was increased in 11 uric acid stone formers, whereas it was normal in the rest of the patients. Uricine-uric acid potential binding was increased in many uric acid stone formers, despite the absence of uric acid urinary hyperexcretion, whereas it was normal in most of the calcium stone formers and was moderately increased in the gouty patients.

Adult↗
PubMed1976

Isolation and characterization of uricine from uric acid stones.

Uricine was found to be present in all uric acid stones tested, although another physiochemically related pigment was occasionally present. Uricine is of low molecular weight (28.2) and a preliminary analysis of its structure suggests that it is formed by two pyrrolic rings. It is a yellow pigment whose color is pH-dependent, shifting from reddish-yellow to green at pH 1.0. It is water soluble, but its solubility increases in alkaline solutions. Preliminary evidence suggests that uricine is related metabolically to bilirubin-like compounds.

Chemical Phenomena↗