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Biomedical subjects

B Pierquin

Publications and source records attributed to B Pierquin.

At least 91 records · Page 5Linked to original sources
PubMed1980

[Endocurietherapy of basal-cell epitheliomas of the face (author's transl)].

The diagnosis of basal cell epitheliomas of the face is usually made at an early stage (lesions of less than one centimetre in diameter) in France. Because of their good prognosis, without metastatic risk (95% recovery rate), therapy can be chosen as a function of its cost and the esthetic result obtained. The author considers that surgery, endocurietherapy with iridium, and plesioradiotherapy are equally effective but should be chosen according to the extent and location of the lesion. The ear, and to a lesser degree the nose, are the major indications for curietherapy. For the cyclids and flat surfaces (temporal or frontal regions etc...) surgery, and plesioradiotherapy are the treatment of choice.

Brachytherapy↗
PubMed1980

[Comments about use of polychemotherapy MOPP associated with radiotherapy in the treatment of early stages of Hodgkin's disease. Preliminary report of 58 patients (author's transl)].

58 patients with early stages of Hodgkin's disease (I, II, III l) were treated by 3 courses of MOPP chemotherapy followed by extended field irradiation. After 31 to 72 months follow up 87,8 p. 100 of patients are alive in complete remission. The study of the group deserves two comments: 1. Adjuvant MOPP polychemotherapy may be useful, only when a complete response is obtained after 3 courses, when it is so a complete remission of long duration may be hoped in nearly 100 p. 100 of cases. 2 After complete remission induced by combined chemotherapy and radiotherapy, maintenance chemotherapy seems to be useless.

Adolescent↗
PubMed1979

[Prevention of sequelae after transcutaneous radiotherapy for epitheliomas of the oral cavity (author's transl)].

Close cooperation between the radiotherapist, surgeon, and patient is necessary in order to prevent sequelae following transcutaneous radiotherapy for epitheliomas of the oral cavity. The most effective therapeutic results combined with a minimum of sequelae are obtained by the use of a good irradiation technique, close supervision, careful treatment of any oral or dental affection, prescribing simple medications only, and stopping the use of tobacco and alcohol.

Humans↗
PubMed1979

[Factors favouring necrosis after curietherapy for oral cavity epitheliomas (author's transl)].

The authors studied the factors which favour necrosis after curietherapy, in a series of 82 patients with epithelioma of the oral cavity and a previous series of 280 cases. The principal factor is the size of the tumor. The other factors (macroscopic appearance, dose, quantity of radioactive material, degree of inhomogeneity, distance between the lines, association with external irradiation), are or only moderate importance, as shown by the variations observed, though they are difficult to evaluate in an exact manner, partly for methodological reasons. The frequency of necrosis of bone tissue is directly relaxed to the number of radioactive lines in contact with the maxilla. Alcohol and tabacco abuse have a definite influence but this cannot be calculated. In conclusion, therefore, it would appear possible to reduce the frequency of necrotic lesions by reducing the tumoral size by curietherapy, by applying no more than 2 lines in contact with the mandible for bony necrotic lesions, and by stopping the abuse of alcohol and tobacco.

Humans↗
PubMed1978

The Paris system in interstitial radiation therapy.

As a result of almost 20 years' experience using 192Ir wires in interstitial radiation therapy, a new method of dose calculation has been evolved, which is especially suitable for the techniques employed. Because this system was developed and brought into routine use in Paris, it was called the Paris System. Its basic principles are outlined in this report and the manner in which it is used in clinical practise is explained.

Breast Neoplasms↗
PubMed1978

[Present day development of the Paris System. First part: coplanar patterns and those called "in squares" (author's transl)].

The Paris System is a previsional dosimetric system which facilitates the work of curietherapists working with iridium 192 wires. Introduced about twelve years ago for radio-active implantations in one linear plane, this system has now become more generalized for implantations in two or more linear planes. After a brief review of the principles on which the Paris System is based, and introducing the new definitions arising from its development, the authors present the results of a systematic computerized study. The results obtained were used to establish, among others, the simple relationships between the geometric implantation data (disposition, length, number, separation... of the radioactive lines) and the dimensions of the volume treated, for the coplanar patterns and those called "in squares",

Humans↗
PubMed1977

Endocurietherapy of penis cancer.

Forty-five carcinomas of the penis have been treated with curietherapy using 192Ir to a dose of 6500 rad. With a minimum follow-up of 4 years, it appears that small lesions (less than 30 mm) have excellent local results (2 recurrences in 14 cases). With only a slight potential for lympatic extension, these patients are alive without evidence of disease after 4 years. The lesions of moderate size (30-40 mm) have a poorer prognosis because of more frequent lymphatic extention and disseminated metastases; in contrast, the local results are still quite satisfactory (4 recurrences in 24 cases). The large lesions (more than 40 mm) recur or necrotize (5 recurrences and 2 necroses in 7 cases). In conclusion, curietherapy of epidermoid carcinomas of the penis is an excellent primary treatment for small or moderate lesions (T1, T2, and T3a) if one wishes to avoid surgical mutilation.

Carcinoma, Squamous Cell↗
PubMed1977

[Radical radiotherapy of breast cancer. Experience of Créteil].

Since 1961, we have treated 400 cases of breast cancers by radical radiotherapy (December 1976). The TNM classification of cases is: 25 per cent T1, 55 per cent T2, 20 per cent T3. 80 per cent of patients are N0 or N1a, 20 per cent are N1b. The therapeutic protocal is: for T1 lesions, lumpectomy plus radical radiotherapy, then boost dose with electrons to the axilla (24 Gy) and to the internal mammaryzone (15 Gy), and finally boost dose to the zone of the breast tumor by Iridium 192 implant therapy (25 Gy);--for T2 and T3 lesions, radiotherapy alone with a higher boost dose to the breast tumoral zone (37 Gy). The mammary tumor (or the tumoral zone) receives a total dose between 70 Gy (T1) and 90 Gy (T2 and T3). The five year results for 328 patients with at least one year follow up (actuarial calculations) yield a survival of 89 per cent T1, 84 per cent T2, and 66 per cent T3. The local recurrences are 8 per cent T1, 10 per cent T2, and 26 per cent T3; they can be rectified, under the condition of regular surveillance, by radical surgery. As to the cosmetic results, they are in one half of the cases quite good, in most others satisfactory, in a few poor. We add a prophylactic chemotherapy in the cases with high metastatic risk, i.e. T3 or N1b cases. This therapeutic protocol seems to be highly recommendable for T1 tumors, acceptable for T2, disputable for T3.

Breast Neoplasms↗
PubMed1977

[81 cases of Hodgkin's disease treated with extensive radiotherapy, including 65 with primary MOPP chemiotherapy (author's transl)].

Study 81 cases of Hodgkin's disease at stages I, II or III led to the following conclusions from a therapeutic standpoint (in relation to the apparent results obtained): The addition of chemotherapy on the form of three courses of MOPP before irradiation improved the results of the latter on the one hand and, principally, by reducing the number of failures and, secondly, by reducing the complications. The addition of chemoprophylaxis by MOPP in patients in complete remission as a result of initial treatment, involving an association of 3 courses of MOPP followed by radiotherapy, was not shown to be useful. A major factor in prognosis would to be the clinical and radiological situation after the first three courses of MOPP (in the context of combined MOPP and radiotherapy) since, despite the later radiotherapy, numerous failures were noted in the absence of remission after the three MOPP treatments, whilst failure rarely occurred under the opposite set of circumstances. This is important, since modest treatment would seem to suffice in patients reacting well to three initial MOPP treatments, whilst it is essential to reinforce it when this is not the case.

Drug Therapy, Combination↗
PubMed1977

[Endocurietherapy for carcinoma of the penis (author's transl)].

46 cases of epithelioma of the penis treated by endocurietherapy (Iridium 192) are analysed, with a minimum follow up to of 5 years. The local results appear to be excellent for small lesions, of the order of 20 mm, with only 2 recurrences out of 14 cases. With a slight potential of lymphatic spread, 12 of the patients are apparently cured. The organ has been preserved in perfect functional state. More extensive lesions, but less than 40 mm in size, have a less satisfactory prognosis by virtue of more frequent lymph node spread, difficult to control, and their general course. However local results remain quite respectable, despite 5 recurrences out of 25 cases, 3 of which were easily "salvaged" by surgery. 12 of these patients are apparently cured and in 9 the organ has been preserved in satisfactory functional condition. By contrast, massive forms, larger than 40 mm, recur or necrose and thus represent a poor indication for curietherapy. In conclusion it may be said that endocurietherapy for carcinoma of the penis, by virtue of a technique rendered opitmal by accurate prior dosimetry, is certainly an excellent therapeutic option for all small or moderately extensive lesions, avoiding mutilation. The presence of lymph node involvement has an unfavourable influence on prognosis.

Humans↗
PubMed1977

[Chemotherapy-radiotherapy association in the treatment of localized forms of Hodgkin's disease. Prognosis of polychemotherapy after three trials of M.O.P.P].

63 patients with Hodgkin disease of limited extent (I, II, III) are treated with two protocols: extended field irradiation versus chemotherapy (M.O.P.P.) + extended field irradiation. Three points are suggested by analysis of the results: 1) Advantage from the combination of chemotherapy-radiotherapy. 2) Resistance to chemotherapy frequent innodular sclerosis. 3) In patients treated with chemotherapy the reaction has a prognostic value: failure of treatment being seen only in patients who did not obtain a complete remission.

Drug Therapy, Combination↗
PubMed1976

The destiny of brachytherapy in oncology.

At the invitation of the American Radium Society, Pierquin reviews his very large experience with continuous low dose rate irradiation of cancer. The target volume is treated with 6,000-7,000 rad in 3-10 days at a dose rate of 30-100 rad/hr. Preference for continuous low dose rate irradiation is based on the earlier work of Jean Pierquin, Georges Richard, Claudius Regaud, and Ralston Paterson with radium sources. Afterloading techniques with iridium-192 have been substituted allowing safer and more precise placement. An accumulated experience with 5,000 patients over the past 15 years permits conclusions that the techniques are safe, easy, inexpensive, and effective for tumors accessible to direct instrumentation. Dosimetry is based on the Paris system. Standardizing upon a dose of 7,000 rad, Pierquin concludes there is an isoeffect of continuous radiation at low dose rates of 25-100 rad/hr. The differential effect on tumor versus healthy tissue is impressive even when large volumes are irradiated, as in neck adenopathy. Stemming from this experience, three trials have been carried out of low dose rate teletherapy with cobalt-60 sources in oral cavity and oropharynx tumors, delivering 7,000 rad at rates of 90-100 rad/hr. Pierquin hopes for the same very high local control rates (in the order of 95%)achieved by iridium-192 endoradiotherapy of accessible T1, T2, T3, and T4 cancers.

Europe↗
PubMed1976

Radiation therapy in the management of primary breast cancer.

Since 1960, six cancer centers in France have used radiotherapy alone (with or without tumorectomy) in the treatment of "operable" breast carcinomas. The technique at Hopital Henri Mondor (Creteil) includes a basic irradiation of 5,000 rad to the breast, 4,500 rad to the chest wall, and 4,500 rad to the axillary, supraclavicular, and internal mammary nodal areas. Boost doses of 1,500-2,500 rad to the axillary and internal mammary nodes are given with electrons. A boost dose of 4,000 rad is given to the primary tumor site in the breast by endocureitherapy. Results appear equivalent to those obtained with surgical techniques. Esthetic results are, on the whole, satisfactory. Definitive results will be reported several years hence.

Breast Neoplasms↗
PubMed1976

[Semi continuous low rate irradiation by telecobalt (author's transl)].

The current status of knowledge regarding low rate telecobalt irradiation does not permit any definitive conclusions. However, it has shown that this technique of irradiation, on condition that it is given in two fractions separated by three weeks, is without major risk for healthy tissue, the tolerance of skin being particularly remarkable, and with immediate very satisfactory results on the tumour. Strict statistical comparison will be necessary, however, if a final judgment is to be made. Thus a study group of the O.E.R.T.C. has decided to undertake a comparative study between classical fractioned irradiation and semi-continuous low rate irradiation. The trial involves only cancers of the base of the tongue he has began in January 1976.

Cobalt Radioisotopes↗