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Biomedical subjects

B Phelps-Sandall

Publications and source records attributed to B Phelps-Sandall.

5 recordsLinked to original sources

Outcomes after rollerball endometrial ablation for menorrhagia.

OBJECTIVE: To evaluate the outcomes of women undergoing rollerball endometrial ablation for menorrhagia and to identify factors associated with those outcomes. METHODS: Data on the clinical history, operative technique, and follow-up status as of August 1998 were obtained by retrospective medical record review for 240 women undergoing rollerball endometrial ablation with or without resection of polyps or myomas from January 1991 through December 1996. The incidence of subsequent hysterectomy was calculated by survival analysis, and Cox proportional hazard models were used to identify the predictors of success or failure of the procedure. RESULTS: The mean follow-up time was 31.2 months. Twenty-nine women (31% of the available subjects) who had not undergone hysterectomy were still being monitored 5 years after the rollerball endometrial ablation. Overall, the probability of no hysterectomy in the first 5 years was 71%. Ablation was repeated in 10 patients, six of whom eventually underwent hysterectomy. Multivariate analysis identified previous tubal ligation as a statistically significant positive predictor of the risk of hysterectomy (hazard ratio 2.20, 95% confidence interval [CI] 1.18, 4.09). Women at least 45 years old had a lower risk of subsequent hysterectomy than those younger than 35 years of age (hazard ratio 0.28, 95% CI = 0.10, 0.75). CONCLUSION: The results of this study confirm the effectiveness of rollerball endometrial ablation for the treatment of menorrhagia for a longer duration of follow-up than in most previous reports. Repeated ablation and a younger age at the time of ablation increase the risk of requiring a subsequent hysterectomy.

Adult↗

A prenatal diagnostic center's first-year experience with the California alpha-Fetoprotein Screening Program.

The University of California Davis Medical Center has offered secondary and tertiary care to pregnant patients with abnormal maternal serum alpha-fetoprotein levels since the start of the California alpha-Fetoprotein Screening Program in April 1986. In our first year of involvement with this method of prenatal screening, 452 patients were referred to our center for further evaluation and follow-up of either high or low maternal serum alpha-fetoprotein levels, as determined by the standard multiple of the median adjusted for maternal weight, race, and presence of insulin-dependent diabetes mellitus. This article presents the first-year results of our clinical experience. Information is presented concerning medical complications, screening and diagnostic test results and their confirmation, clinical procedures performed, and postpartum follow-up reports. Findings of pregnancy outcomes associated with low and high alpha-fetoprotein levels are presented and discussed.

Adult↗

Analysis of the significance of discolored amniotic fluid detected at midtrimester amniocentesis.

In 110 midtrimester amniocenteses of the 3349 procedures done at the University of California, Davis, Medical Center between 1979 and 1984, the fluid obtained was noted to be discolored. The significance of this finding was evaluated with review of pregnancy history and outcome and by using biochemical techniques. A significant increase in miscarriage was seen in the pregnancies where discolored fluid was obtained (9%), in comparison with the entire group of pregnancies in which amniocentesis was done at the same institution over the same period (1.6%). This increase was most marked in the pregnancies in which, in addition to discolored fluid, there was a prior history of pregnancy bleeding. Thirty-four discolored fluid samples and 18 clear fluid samples were studied with spectrophotometry, electrophoresis, isoelectric focusing, and chromatography. These studies indicate that in most cases the discoloring pigment is blood rather than fetal bowel contents, as had been suggested by others.

Abortion, Spontaneous↗