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Biomedical subjects

B Petruson

Publications and source records attributed to B Petruson.

At least 73 records · Page 4Linked to original sources

Structural and functional aspects of cells in the nasal mucociliary system.

The regulation of the fluid balance of the mucus is important for a good function of the mucociliary system in the nose. The nasal glands and the goblet cells have been proposed to be the main source of fluid. Microvilli-equipped epithelial cells, ciliated and nonciliated, constituting 70% to 90% of the cells on the turbinates in the nose, are of importance for the regulation of the hydration of the mucus. These cells have the same characteristics as other fluid-secreting cells elsewhere in the body. They have microvilli, a terminal web, folding of the basolateral membrane, and numerous cell organelles. Blockage of the energy supply strongly reduces the fluid secretion.

APUD Cells↗

Electrically induced short-lasting tetanus of the calf muscles for prevention of deep vein thrombosis.

Electrical calf muscle stimulation during surgery has been used for the prevention of deep vein thrombosis (DVT) with varied results in several studies. This effect is mainly achieved by the reduction of venous stasis in the legs. Another possible beneficial effect might be an increased fibrinolytic activity of the blood secondary to the muscle contractions. Previously, single electrical impulses have been used for stimulation, giving rise to 'single twitches' in the muscles. In the present study the effect on calf volume of muscle stimulation with groups of impulses giving a short-lasting tetanus was investigated. Changes in calf volume were recorded by strain gauge plethysmography. Optimal values for duration, number and frequency of the impulses within the groups were determined. Stimulation with groups of impulses reduced calf venous volume approximately three times more efficiently than stimulation with single impulses. Calf muscle stimulation did not enhance the increase in fibrinolytic activity of venous blood observed after oesophago- or laryngoscopies under general anaesthesia.

Adult↗

Treatment with xylometazoline (Otrivin) nosedrops over a six-week period.

Twenty healthy subjects were treated with xylometazoline 1 mg/ml for six weeks in order to study the occurrence of tachyphylaxis and rhinitis medicamentosa. Each subject instilled 0.15 ml of xylometaxoline nose-drops into each nostril three times a day. Posterior rhinomanometry was performed before the trial started, after 1, 2, 4 and 6 weeks treatment and 20, 27, 40 and 48 hours after the subject had taken the nose-drops for the last time. With rhinomanometry it was possible in this study to show that the same dose was adequate during the whole six-week period, i.e. no tachyphylaxis was observed. No reactive congestion was observed after the trial was finished.

Adult↗

The influence of acetylsalicylic acid and paracetamol on menstrual blood loss in women with and without an intrauterine contraceptive device.

The influence of ASA and paracetamol on menstural blood loss and on some hematologic parameters was investigated in 23 women without an IUD and 10 women with an IUD. Neither in women with normal nor in women with small defects in the hemostatic mechanism were statistically significant increases in menstrual blood losses observed during treatment with ASA or paracetamol when compared to placebo. There was no linear correlation between bleeding time and basal menstrual blood loss or between the blood losses induced by ASA and paracetamol and the bleeding time.

Acetaminophen↗

Vestibulospinal reflex activity in patients with adolescent idiopathic scoliosis. Postural effects during caloric labyrinthine stimulation recorded by stabilometry.

Postural sway has been quantified with stabilometry during caloric labyrinthine stimulation in an erect posture in 49 patients, aged 10--16 years, with adolescent idiopathic scoliosis. Thirty-two healthy children of the same age constituted a control group. The scoliotic patients tended to have an increased postural sway during labyrinthine stimulation on the convex side compared to the effects on the concave side. Significant differences were observed when left and right scoliotic patients were compared with the controls. The results can be explained by an asymmetric sensitivity in the labyrinth or by a dysfunction in the postural control mechanisms at the brain stem level.

Adolescent↗

A study of labyrinthine function in patients with adolescent idiopathic scoliosis. I. An electro-nystagmographic study.

An electro-nystagmographic study of labyrinthine function was performed in 56 patients with adolescent idiopathic scoliosis (AIS)aged from 10 to 16 years. Forty-seven patients had major structural single curvatures, and nine patients had double-primary scoliosis and were analysed separately. Treatment was required in 36 cases while 20 were being observed only. Thirty healthy children of the same ages constituted a control group. Spontaneous nystagmus (SN) and positional nystagmus (PN) were found in 24 out of the 47 patients with single curvatures and in only one subject in the control group (P less than 0.001). No significant correlation was noted between direction of convexity and nystagmus. Neither did the frequency of SN or PN differ significantly between patients requiring treatment and patients submitted to observation only. Significant differences were observed in the caloric response between right and left scoliotic patients (P less than 0.05). The right convex patients had a sensitivity dominance in the right labyrinth and the left convex patients in the left labyrinth. There were no significant differences between right- and left-beating nystagmus. A dysrhythmic nystagmus occurred in the scoliotic patients with significantly increased frequency (P less than 0.05). The results are discussed with special reference to aetiology in AIS. It was difficult, however, to draw any definite conclusion as to whether the findings may indicate a causative factor in relation to the idiopathic curvature or whether they might be a feed-back effect from the deformed spine.

Adolescent↗

Postural effects on nystagmus response during caloric labyrinthine stimulation in patients with adolescent idiopathic scoliosis. II. An electro-nystagmographic study.

An electro-nystagmographic study of postural effects on the nystagmus response has been performed in 40 patients with adolescent idiopathic scoliosis aged from 10 to 16 years. The control group comprised 29 healthy children of the same age. Caloric labyrinthine stimulation was done in the supine and erect position. The results were analysed with the aim of finding out whether an increased scoliotic deformity might influence the labyrinthine response. For comparison of the nystagmus response in the two different positions a quotient of the values (degrees/second) obtained from cold water stimulation in the erect and supine position was calculated. In the control children the labyrinthine response in erect posture was half of the response in supine posture. In erect posture the scoliotic deformity increased. This obvious change in the spine did not increase the caloric response from the convex side labyrinth. The predominance of the convex side labyrinth observed in the supine position was thus not seen in the erect position. The results of this study did not support the assumption that a postural deformity in the spine can influence a calorically induced labyrinthine response.

Adolescent↗

Influence of acetylsalicylic acid and paracetamol on menstrual blood loss.

In a double-blind cross-over study the influence of acetylsalicylic acid (ASA) and paracetamol on menstrual blood loss has been investigated in 23 women without an intrauterine loop or birth control pills. After intake of ASA there was no significantly, increased blood loss compared with intake of placebo or paracetamol.

Acetaminophen↗