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Biomedical subjects

B Pesce

Publications and source records attributed to B Pesce.

14 recordsLinked to original sources
PubMed1998

Pten is essential for embryonic development and tumour suppression.

The PTEN gene encodes a dual-specificity phosphatase mutated in a variety of human cancers. PTEN germline mutations are found in three related human autosomal dominant disorders, Cowden disease (CD), Lhermitte-Duclos disease (LDD) and Bannayan-Zonana syndrome (BZS), characterized by tumour susceptibility and developmental defects. To examine the role of PTEN in ontogenesis and tumour suppression, we disrupted mouse Pten by homologous recombination. Pten inactivation resulted in early embryonic lethality. Pten-/- ES cells formed aberrant embryoid bodies and displayed an altered ability to differentiate into endodermal, ectodermal and mesodermal derivatives. Pten+/- mice and chimaeric mice derived from Pten+/- ES cells showed hyperplastic-dysplastic changes in the prostate, skin and colon, which are characteristic of CD, LDD and BZS. They also spontaneously developed germ cell, gonadostromal, thyroid and colon tumours. In addition, Pten inactivation enhanced the ability of ES cells to generate tumours in nude and syngeneic mice, due to increased anchorage-independent growth and aberrant differentiation. These results support the notion that PTEN haploinsufficiency plays a causal role in CD, LDD and BZS pathogenesis, and demonstrate that Pten is a tumour suppressor essential for embryonic development.

Adenocarcinoma↗
PubMed1985

Digital angiography in evaluation of orthopedic tumors.

Preoperative evaluation of orthopedic tumors using digital subtraction angiography (DSA) proved useful to ascertain the nature of the lesion, its extension to soft tissues and joints, and the presence of arteriovenous (AV) shunts. We report that overall accuracy varied from 89% to 92%, depending on the feature evaluated. The importance of angiographic examination of this entity is discussed as well as the advantages of DSA over conventional angiography.

Angiography↗
PubMed1985

Digital celiac arteriography.

Sixty patients underwent intraarterial DSA with injection into the celiac artery for evaluation of various hepatic, pancreatic, and splenic lesions. Twenty of these patients also underwent conventional arteriography for comparison. Excellent images during the early arterial phase (free of bone superimposition and artifacts) were obtained with DSA. The late arterial and parenchymal phases of the examination were less definitive when compared with conventional angiography. The venous phases of the liver studies were good and compared favorably in contrast and resolution to conventional methods. In the late venous phase, good images of the portal system were obtained using a small amount of contrast medium. Respiratory movements and artifacts were overcome with postprocessing. Most of the studies were performed using the 12-inch mode of the image intensifier, which represents the best choice between the size of the field examined and the spatial resolution of the system. We believe that DSA is a suitable substitute for conventional angiography in most patients in whom celiac trunk angiography would be used.

Angiography↗
PubMed1985

[Value of splenic embolization in patients with hypersplenism].

The authors describe the importance of embolization of the splenic artery by means of Gianturco coils in splenomegalic portal hypertension. They propose their first experience of six cases and the good results on the basis of clinical parameters, of bleeding of esophageal varices, of hematological values. They also show the influence of this method on hemodynamic, metabolic, and respiratory parameters, altered in cirrhotic patients.

Adult↗
PubMed1983

[Angioplasty of the renal arteries. Our experience with a 12-month follow-up].

We have treated 56 stenoses of renal arteries in 50 patients in which a renin assay indicated renovascular hypertension. In this paper we refer only to 40 cases of renal arteries angioplasty in 37 patients (3 cases of bilateral stenoses) with a clinical follow-up of 12 months. 25 lesions were of arteriosclerotic nature, while 15 were due to fibromuscular displasia. Results demonstrated that angioplasty resolved hypertensive conditions (either with or without medical therapy) in 82% of the cases of arteriosclerotic lesions and in 86% of the stenoses due to fibromuscular displasia. Although extremely rare, the complications that may occur with this procedure are very serious (arterial rupture, acute thrombosis, peripheral embolization). Out of utmost importance is a close collaboration with a vascular surgeon. Without doubt angioplasty will bring about radical changes in the preparation of therapeutical protocol and in some selected cases to improve renal function.

Adolescent↗
PubMedDate not supplied

[Angio-CT in the staging of renal carcinoma].

The authors report the results about the staging of renal carcinoma using "angio-CT". The diagnostic accuracy, the sensibility, the specificity, in 42 patients, have been evaluated and compared with the subsequent operative or authoptic diagnosis. The meaning of this study is the comparison of the results obtained by this method in front of other examinations, especially artheriography.

Carcinoma, Renal Cell↗