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Biomedical subjects

B Pelet

Publications and source records attributed to B Pelet.

31 records · Page 2Linked to original sources
PubMed1980

C3, factor B, alpha-1-antitrypsin in neonatal septicaemia with sclerema.

C3, factor B, and alpha-1-antitrypsin were determined in newborn infants with septicaemia and sclerema, associated with suspected infections, ABO or Rh incompatibility, and hyperbilirubinaemia of unknown origin, during and after treatment with exchange transfusion. Activation products from C3 and factor B, the clearance of the transfused C3, and its synthesis by the recipient were determined also. Infected newborn infants had low levels of C3 and factor B, but a normal amount of alpha-1-antitrypsin. Exchange transfusion lowered the level of alpha-1-antitrypsin and briefly corrected the low level of C3 and factor B. Activation products were formed only exceptionally. As synthesis of C3 is very active, a defective activation of complement pathway linked to an abnormal distribution in extravascular pool is postulated.

Complement C3↗
PubMed1979

Exchange transfusion in newborn infants: effects on granulocyte function.

During 23 exchange transfusions, the granulocytes from 27 donors and 16 newborn infants were tested for opsonic activity and granulocyte function by the nitrobluetetrazolium test. Granulocyte function in a newborn baby receiving an exchange transfusion can be altered positively or negatively, depending on the quality of the donor's blood. If exchange transfusion is used in the management of neonatal sepsis, special attention should be given to the immunological properties of the donor blood.

Exchange Transfusion, Whole Blood↗
PubMed1976

Autologous marrow reconstitutions in severe aplastic anaemia after ALG pretreatment and HL-A semi-incompatible bone marrow cell transfusion.

Three consecutive patients considered to have end-stage acquired aplastic anaemia were given 100-160 mg/kg antilymphocyte globulin (ALG) i.v. followed by an infusion of 2-3.8 x 10(8) nucleated marrow cells/kg i.v. from HL-A one haplotype-identical, MLC-positive family donors. All patients showed autologous marrow reconstitutions lasting now 2-3 1/2 years. No clear-cut evidence of marrow engraftment could be established and no graft-versus-host disease was seen. It is assumed that these patients had some normal pluripotent haemopoetic stem cells which proved to be able of endoreduplication and of going into cycle after ALG conditioning and allogeneic marrow transfusion.

Adult↗
PubMed1976

Immunological decay in thymectomized infants.

Four infants underwent radical thymectomy for a suspected malignancy of the thymus. Histology revealed no malignant cells. The patients did clinically well as long as 14 years after the operation. There was laboratory evidence for a cellular and humoral immunodeficiency. Affected were mainly the response to oral poliomyelitis vaccinations and the skin tests of delayed type hypersensitivity.

Adolescent↗
PubMed1975

Bone marrow transplantation in combined immunodeficiencies.

Correction of combined immunodeficiences was attempted in 4 patients. Attainment of lasting immunologic reconstitution was restricted to an HL-A identical graft. However, HL-A identity was not a safeguard against graft-vs-host reaction (GVHR). Failure of donor-host adaptation resulted in chronic GVHR. In unmatched grafts, alloimmune plasma was capable of only transient amelioration of GVHR. Alloimmune plasma prevented fatal GVHR in one patient receiving a HL-A semiidentical graft. However, no direct evidence for a T-cell engraftment was shown. The failure to prevent GVHR or to reverse an ongoing reaction in incompatible bone marrow transplantations demands a reappraisal of the conceptual approach to immunologic tolerance.

ABO Blood-Group System↗